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Restrospective Study of Apalutamide, Darolutamide and Enzalutamide in Patients with Nonmetastatic, Castrate Resistant Prostate Cancer
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822870 While each of us responds differently to any prescribed drug, this new study reinforces the view that more nonmetastatic, castrate resistant prostate cancer patients may tolerate the side effects of darolutamide better compared to
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822870 While each of us responds differently to any prescribed drug, this new study reinforces the view that more nonmetastatic, castrate resistant prostate cancer patients may tolerate the side effects of darolutamide better compared to
Survivor86
in
Advanced Prostate Cancer
17 days ago
Scientists working to understand why men with prostate cancer are at higher risk of Alzheimer's
Researchers at the Medical College of Georgia at Augusta University are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that actually contributes to the
Researchers at the Medical College of Georgia at Augusta University are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that actually contributes to the
PSAed
in
Advanced Prostate Cancer
17 days ago
Second scan -- now what?
After a year the second scan produced the following impression from the radiologist, "1. Marked improvement in radiotracer avid osteoblastic metastasis and marked improvement in radiotracer avid nodal metastasis. Radiotracer avid disease in the prostate has also markedly improved." Bear in mind that
After a year the second scan produced the following impression from the radiologist, "1. Marked improvement in radiotracer avid osteoblastic metastasis and marked improvement in radiotracer avid nodal metastasis. Radiotracer avid disease in the prostate has also markedly improved." Bear in mind that
Poollover
in
Advanced Prostate Cancer
17 days ago
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Restarting anti androgens after chemo
My husband has completed two years of chemotherapy, followed by Pluvicto. Would it be possible to re-start an anti-androgen ( Zytiga, daralutimide) as therapy? What choices does he have going forward?
My husband has completed two years of chemotherapy, followed by Pluvicto. Would it be possible to re-start an anti-androgen ( Zytiga, daralutimide) as therapy? What choices does he have going forward?
roboocme
in
Advanced Prostate Cancer
17 days ago
Ideas for resistance training which can be done at home ?
I am looking for ideas for resistance training which can be done at home for my father who is 83 yrs and has bone mets in upper femurs , acetabulum , ischeum and some other bones in the body. He also has osteoporosis in femurs but not in hips. He is on orgovyx and xtandi. He walks an hour daily
I am looking for ideas for resistance training which can be done at home for my father who is 83 yrs and has bone mets in upper femurs , acetabulum , ischeum and some other bones in the body. He also has osteoporosis in femurs but not in hips. He is on orgovyx and xtandi. He walks an hour daily
Tinkudi
in
Advanced Prostate Cancer
18 days ago
Why is my PSA so low?
For about 9 years after my last HIFU, my PSA hovered in the 1.0 - 2.0 range, and testosterone around 200 or so. That's what they were in July 2023. But in January 2024, PSA plunged to 0.248 (T wasn't measured then). In early March, PSA continued down to 0.148, and testosterone crashed to 60, and free
For about 9 years after my last HIFU, my PSA hovered in the 1.0 - 2.0 range, and testosterone around 200 or so. That's what they were in July 2023. But in January 2024, PSA plunged to 0.248 (T wasn't measured then). In early March, PSA continued down to 0.148, and testosterone crashed to 60, and free
kapakahi
in
Advanced Prostate Cancer
18 days ago
New diagnosis... & Enzalutamide question
Hi guys, I've been reading these APC posts for a few weeks and I have to say that I massively appreciate your shared knowledge, humour... and grace. It's helped me face where I am, and not paint it too black. Thank you! DX start of July, PSA 530, Gleason 7 (4,3), low volume Metastatic PC with extensive
Hi guys, I've been reading these APC posts for a few weeks and I have to say that I massively appreciate your shared knowledge, humour... and grace. It's helped me face where I am, and not paint it too black. Thank you! DX start of July, PSA 530, Gleason 7 (4,3), low volume Metastatic PC with extensive
Broccoli24
in
Advanced Prostate Cancer
19 days ago
72 year old
So I am a 72 (soon to be 73) White male. I was diagnosed with prostate cancer about 18-20 months ago. I have had three biopsies. The first two were transrectal approach and the last one was peritoneal approach. No issues with either approach. They are painless as they give you a drug to put you
So I am a 72 (soon to be 73) White male. I was diagnosed with prostate cancer about 18-20 months ago. I have had three biopsies. The first two were transrectal approach and the last one was peritoneal approach. No issues with either approach. They are painless as they give you a drug to put you
Dadyrabbit
in
Advanced Prostate Cancer
19 days ago
Retrospective cohort study comparing ARIs; darolutamide, enzalutamide, and apalutamide in 870 non metastatic CRPC patients
In this retrospective study (with limitations) comparing ARIs, darolutamide came out best. The results for enzalutamide and apalutamide were similar. Androgen Receptor Inhibitors in Patients With Nonmetastatic Castration-Resistant Prostate Cancer Daniel J. George, MD; Alicia K. Morgans, MD, MPH; Niculae
In this retrospective study (with limitations) comparing ARIs, darolutamide came out best. The results for enzalutamide and apalutamide were similar. Androgen Receptor Inhibitors in Patients With Nonmetastatic Castration-Resistant Prostate Cancer Daniel J. George, MD; Alicia K. Morgans, MD, MPH; Niculae
Graham49
in
Advanced Prostate Cancer
19 days ago
Elevated Testosterone
I was on Abiraterone and prednisone for 6 months until June 6, 2024. My blood work: 4/25/2024 Testosterone 44 ng/dL, PSA undetectable 5/28 T 35, PSA undetectable 6/6 Stopped Abiraterone 7/8 T 968 PSA 0.21 8/19 T 1475 PSA 0.54 My MO want's to do a PSMA scan in a month. I don't see
I was on Abiraterone and prednisone for 6 months until June 6, 2024. My blood work: 4/25/2024 Testosterone 44 ng/dL, PSA undetectable 5/28 T 35, PSA undetectable 6/6 Stopped Abiraterone 7/8 T 968 PSA 0.21 8/19 T 1475 PSA 0.54 My MO want's to do a PSMA scan in a month. I don't see
rainlessman
in
Advanced Prostate Cancer
19 days ago
Good news after SBRT
My last PSMA pet showed an 8mm prostate tumor in my left lung. My PSA before the radiation was 1.06. 2 weeks after radiation the PSA is <.06. I'm seeing my MO tomorrow to see if he will continue to hold off on ADT. Any suggestion/recommendations? Thanks
My last PSMA pet showed an 8mm prostate tumor in my left lung. My PSA before the radiation was 1.06. 2 weeks after radiation the PSA is <.06. I'm seeing my MO tomorrow to see if he will continue to hold off on ADT. Any suggestion/recommendations? Thanks
old64horn
in
Advanced Prostate Cancer
19 days ago
Tamoxifen side effects
I have a question for tamoxifen users. Not a big deal but I am curious. I am 76 and have been on tamoxifen for a year and a half. I have gray hair - quite long. The hair is thinning but my curiosity is about my hair darkening. It is turning a dark brunette. Just seems kind of weird. Anyone else had that
I have a question for tamoxifen users. Not a big deal but I am curious. I am 76 and have been on tamoxifen for a year and a half. I have gray hair - quite long. The hair is thinning but my curiosity is about my hair darkening. It is turning a dark brunette. Just seems kind of weird. Anyone else had that
Artist_B
in
SHARE Breast Cancer Support
19 days ago
optimal curative therapy?
Very fortunate still to have a chance for cure — Gleason 9 with post surgery LN involvement, but no distant mets detected. Received RT and about half way through a 2-year course of Lupron. PSA undetectable; tolerable SEs. Would adding Abiraterone or Apalutamide now maximize chance of cure or is it better
Very fortunate still to have a chance for cure — Gleason 9 with post surgery LN involvement, but no distant mets detected. Received RT and about half way through a 2-year course of Lupron. PSA undetectable; tolerable SEs. Would adding Abiraterone or Apalutamide now maximize chance of cure or is it better
NickKnick
in
Advanced Prostate Cancer
19 days ago
Advice please
I had a partial thyroidectomy (left removed) in April 2023. I am on 50mg levothyroxine but I am still not feeling right. I am having trouble regulating my temperature, my hair has tinned a lot. I am tired, ache, have put on weight and feel miserable. Keep being told by GP that my TSH is in normal range
I had a partial thyroidectomy (left removed) in April 2023. I am on 50mg levothyroxine but I am still not feeling right. I am having trouble regulating my temperature, my hair has tinned a lot. I am tired, ache, have put on weight and feel miserable. Keep being told by GP that my TSH is in normal range
BlueLido
in
Thyroid UK
19 days ago
Xtandi has failed we think
Hi, back again Ok so the psa has come in and its jumped from 12.8 to 34 in about 7 weeks. Testosterone 0.03 January 2023 with psa of 83 ( this was on a watch and wait process l was started on Zoladex again but after reaching 7.0 psa started rising again, Testosterone 0.02 after 6 months. l was diagnosed
Hi, back again Ok so the psa has come in and its jumped from 12.8 to 34 in about 7 weeks. Testosterone 0.03 January 2023 with psa of 83 ( this was on a watch and wait process l was started on Zoladex again but after reaching 7.0 psa started rising again, Testosterone 0.02 after 6 months. l was diagnosed
Knittingque
in
Advanced Prostate Cancer
19 days ago
Iron Induces Cell Death and Strengthens the Efficacy of Antiandrogen Therapy in Prostate Cancer Models, Cinical Cancer Research, 2020 Dec 1
The following paper from 2020 might be of interest to those using the antiandrogen bicalutimide as a major component in their treatment programs. Much has been made of cancer cell death by ferroptosis and from this first paper it seems probable that there is some potential synergy between iron supplementation
The following paper from 2020 might be of interest to those using the antiandrogen bicalutimide as a major component in their treatment programs. Much has been made of cancer cell death by ferroptosis and from this first paper it seems probable that there is some potential synergy between iron supplementation
cujoe
in
Fight Prostate Cancer
19 days ago
Docetaxel
After 7 years of various treatments including RP, Radiation and ADT My husband has begun Chemo (Docetaxel) His first infusion was at a reduced dosage and after the first reduced dose infusion his PSA went from 47 to 32. After his Second infusion his PSA went from 32 to 18. My question is, is it possible
After 7 years of various treatments including RP, Radiation and ADT My husband has begun Chemo (Docetaxel) His first infusion was at a reduced dosage and after the first reduced dose infusion his PSA went from 47 to 32. After his Second infusion his PSA went from 32 to 18. My question is, is it possible
JolleySprings
in
Advanced Prostate Cancer
19 days ago
Smear test hell
Hi ladies. Another year another horrific cervical smear experience. I’m at a loss as to what to do, i want to get the test but I just cannot bear the pain it causes me. At least now I know it is - at least to some extent - a result of my endo. Just wondering if anyone got any ideas or tips to make it
Hi ladies. Another year another horrific cervical smear experience. I’m at a loss as to what to do, i want to get the test but I just cannot bear the pain it causes me. At least now I know it is - at least to some extent - a result of my endo. Just wondering if anyone got any ideas or tips to make it
TandE
in
Endometriosis UK
20 days ago
Boron - Bone Health and a whole lot more!
Nothing Boring about Boron Lara Pizzorno. Integr Med (Encinitas). 2015 Aug. "the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body's
Nothing Boring about Boron Lara Pizzorno. Integr Med (Encinitas). 2015 Aug. "the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body's
kainasar
in
Advanced Prostate Cancer
20 days ago
Orgovyx after 12 months
Just reaching the 12 month mark on Orgovyx. Lately, it is beginning to kick my ass. Just feel weak, depressed and unmotivated to exercise. Getting tired of hot flashes. I have put on about 15 lbs. since beginning ADT prior to radiation therapy. I was diagnosed GG3 (4+3=7), T2bN0M0. Lesion on one half
Just reaching the 12 month mark on Orgovyx. Lately, it is beginning to kick my ass. Just feel weak, depressed and unmotivated to exercise. Getting tired of hot flashes. I have put on about 15 lbs. since beginning ADT prior to radiation therapy. I was diagnosed GG3 (4+3=7), T2bN0M0. Lesion on one half
805guy
in
Prostate Cancer Network
20 days ago
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