Xtandi has failed we think

[Knittingque]

Hi, back again

Ok so the psa has come in and its jumped from 12.8 to 34 in about 7 weeks. Testosterone 0.03

January 2023 with psa of 83 ( this was on a watch and wait process l was started on Zoladex again but after reaching 7.0 psa started rising again, Testosterone 0.02 after 6 months.

l was diagnosed as non met castrate resistant, by now l was referred to an Oncologist however the Cancer Agency lost my records on there computer system during renovations Big delays ocurred.

Finally l saw my Onc in Nov 2023 and was told that l would stay on Adt for life but he would add Xtandi to the mix.l decided that l d idn't want to be on adt injections for life so l made the decision and had a Bilateral Orchiectomy in March 2023 that went well.

November 2023 put on Xtandi 160mg, have suffered dreadful side effects. Blood Pressure skyrocketed Xmas Day now on 2 BP meds, Onc dropped to 3 pills, then to 2, then back upto 3 horrendous headaches. Stopped taking meds on Monday this week cannot function with the headaches.

l had bloodwork done Monday as well. Psa as stated above has gone up, l am having a conversation with my Onc on Friday this week on what happens next. Is Daralutimide a good choice next?

Been doing this since 2013 had some good years and bad but l keep positive and try very hard to exercise on my bike as much as possible.

Any help, advice on next step would be useful.

Thanks again everyone

[street-air]

Nubeqa is somewhat similar to Xtandi. If xtandi has ceased to work the next possible steps are docetaxel with a steroid or cabazitaxel. The other options are provenge or keytruda (immunotherapies) or certain target therapies if there is a cancer gene profile that indicates they will work, and then there are radiotherapy options like pluvicto.. Another option is getting in on a trial of ARX517 as at least one member here seems to have failed Xtandi and responded on this trial.

[Knittingque in reply to street-air]

Thank you for replying l am in Canada and there are no Trials for ARX517 as far as l can see. Maybe in the near future. In the meantime l think l will try Nubeqa and keep fingers crossed it lasts longer than Xtandi but with less side effects. Keep the faith and Cheers.