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Melatonin
https://www.nature.com/articles/s41440-019-0223-9 I am wondering if anyone uses melatonin to slow progress of kidney disease? Although seen primarily as a sleep aid melatonin has many beneficial effects throughout the body. I have been taking 20 mg per night for 4 years for another issue with beneficial
https://www.nature.com/articles/s41440-019-0223-9 I am wondering if anyone uses melatonin to slow progress of kidney disease? Although seen primarily as a sleep aid melatonin has many beneficial effects throughout the body. I have been taking 20 mg per night for 4 years for another issue with beneficial
alexask
in
Kidney Disease
2 years ago
Excellent sleep aid
Hi gang. You all know the trouble I’ve had sleeping recently. Well last night I added two new elements to my routine: CBD oil and this product from a Canadian? firm called Comfort Linen . The sheets etc are designed to work together and I must say I was very impressed with the freeing up of my movements
Hi gang. You all know the trouble I’ve had sleeping recently. Well last night I added two new elements to my routine: CBD oil and this product from a Canadian? firm called Comfort Linen . The sheets etc are designed to work together and I must say I was very impressed with the freeing up of my movements
jeeves19
in
Cure Parkinson's
2 years ago
Asking a question on behalf of my Mum with regards to a hysterectomy. Ladies who have had it what did you keep?
My mum is 51 has always suffered with extremely heavy periods and as she has gotten older this has gotten significantly worse. After being put on iron tablets and tranexamic acid by the GP with not much relief she was referred to a gynaecologist. The gynaecologist examined her and said her uterus
My mum is 51 has always suffered with extremely heavy periods and as she has gotten older this has gotten significantly worse. After being put on iron tablets and tranexamic acid by the GP with not much relief she was referred to a gynaecologist. The gynaecologist examined her and said her uterus
JadeH92
in
Endometriosis UK
2 years ago
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imuran
I have been on Imuran 50mg for over 3 years and will be on it another 2 for autoimmune hepatitis. I also have PBC and take ursodiol for that. Imuran has lowered my liver levels and has kept them stable for me. It suppresses your immune system but it’s manageable. My dr is hoping that after being on it
I have been on Imuran 50mg for over 3 years and will be on it another 2 for autoimmune hepatitis. I also have PBC and take ursodiol for that. Imuran has lowered my liver levels and has kept them stable for me. It suppresses your immune system but it’s manageable. My dr is hoping that after being on it
JJBae
in
PBC Foundation
2 years ago
Pill Gets Stuck
I have been taking Alendronate once weekly for a month. The pill keeps getting stuck in my throat. I drink a full glass of water before taking the pill and another glass afterward. I am also standing. I was hesitant to start this med. Now I am afraid of doing damage to my esophagus and thinking
I have been taking Alendronate once weekly for a month. The pill keeps getting stuck in my throat. I drink a full glass of water before taking the pill and another glass afterward. I am also standing. I was hesitant to start this med. Now I am afraid of doing damage to my esophagus and thinking
Capan24
in
Osteoporosis Support
2 years ago
Advice on Results Please
Hello, I've been trying to find my sweet spot since starting HRT and discovering I was undermedicated. I've just had my latest test results back although I keep having issues with the blood samples for Medichecks so some tests have been redone and other are missing. Anyone else have issues with this
Hello, I've been trying to find my sweet spot since starting HRT and discovering I was undermedicated. I've just had my latest test results back although I keep having issues with the blood samples for Medichecks so some tests have been redone and other are missing. Anyone else have issues with this
FAB-jellybean
in
Thyroid UK
2 years ago
Supplements after EC
Hi all, I've been taking co enzyme q10, omega 3, and pregnacare supplements. I had EC today and just wondering do I now stop taking the Co enzyme q10 and omega 3?? Or should I carry on until embryo transfer....or even keep taking them during the 2ww? Thanks x
Hi all, I've been taking co enzyme q10, omega 3, and pregnacare supplements. I had EC today and just wondering do I now stop taking the Co enzyme q10 and omega 3?? Or should I carry on until embryo transfer....or even keep taking them during the 2ww? Thanks x
Redbadger
in
Fertility Network UK
2 years ago
Joint issues
Hi all, first post here. I have been experiencing ongoing, worsening joint symptoms - soreness, stiffness, grating and grinding sensations, weakness, mild pain in various joints - outer elbow, base of thumbs, wrists, neck and knees. I first saw a Rheumatologist in 2015 and was diagnosed with joint hypermobility
Hi all, first post here. I have been experiencing ongoing, worsening joint symptoms - soreness, stiffness, grating and grinding sensations, weakness, mild pain in various joints - outer elbow, base of thumbs, wrists, neck and knees. I first saw a Rheumatologist in 2015 and was diagnosed with joint hypermobility
ZM1980
in
Arthritis Action
2 years ago
New diagnosis osteoporosis
Morning Everyone, I've just been notified I have osteoporosis after I mentioned to my GP Practice that I'd not had a scan for many years. I've been told about zoledronic acid which they want to give me. I thought my diet was quite good but she said its likely the long term RA, menopause, steroids over
Morning Everyone, I've just been notified I have osteoporosis after I mentioned to my GP Practice that I'd not had a scan for many years. I've been told about zoledronic acid which they want to give me. I thought my diet was quite good but she said its likely the long term RA, menopause, steroids over
sunnyweek
in
NRAS
2 years ago
should I be concerned about skincare products while pregnant?
I’m 11 weeks pregnant and have been using my usual skincare products. They are over the counter and geared towards acne so have salicylic acid. My doctor said to send a list of the ingredients which I did and she’s responded to say there’s evidence that they’re safe in pregnancy so to stop using
I’m 11 weeks pregnant and have been using my usual skincare products. They are over the counter and geared towards acne so have salicylic acid. My doctor said to send a list of the ingredients which I did and she’s responded to say there’s evidence that they’re safe in pregnancy so to stop using
Brandi1234
in
Pregnancy and Parenting Support
2 years ago
Docosahexaenoic Acid Reverses Epithelial-Mesenchymal Transition and Drug Resistance ...
New Chinese cell study [1]. Docosahexaenoic Acid [DHA] is one of the two marine omega-3 fatty acids that people seem to have become bored with. Are supplements good or bad? Why do the softgels have an "off" taste? Is the oil oxidized, rancid, etc."I like to get my DHA from fish. For breakfast I
New Chinese cell study [1]. Docosahexaenoic Acid [DHA] is one of the two marine omega-3 fatty acids that people seem to have become bored with. Are supplements good or bad? Why do the softgels have an "off" taste? Is the oil oxidized, rancid, etc."I like to get my DHA from fish. For breakfast I
pjoshea13
in
Fight Prostate Cancer
2 years ago
i have depression, suicidal ideation and I don't know what to do.
it took me two weeks to taper from lexapro to Cymbalta. I've now been on Cymbalta since 10.14.22 (2 weeks) at 60. I'm also on lithium. I have had very weird side effects. It was very hard for me to sleep. Sometimes 3 or 4 hours,sometimes up all night. We kept switching Cymbalta from day to night and
it took me two weeks to taper from lexapro to Cymbalta. I've now been on Cymbalta since 10.14.22 (2 weeks) at 60. I'm also on lithium. I have had very weird side effects. It was very hard for me to sleep. Sometimes 3 or 4 hours,sometimes up all night. We kept switching Cymbalta from day to night and
Joshgw
in
Anxiety and Depression Support
2 years ago
update on my post about my colonoscopy on August 6th while on 3.5mg of Prednisolone.
Hi all, I’m sure I had very little sedation because I felt so much pain during the colonoscopy that I thought they’d forgotten to give me any. Only one polyp & 2 biopsies were removed & it felt like I was awake during the whole procedure, which I wasn’t as it took 40 minutes. I even felt the scope
Hi all, I’m sure I had very little sedation because I felt so much pain during the colonoscopy that I thought they’d forgotten to give me any. Only one polyp & 2 biopsies were removed & it felt like I was awake during the whole procedure, which I wasn’t as it took 40 minutes. I even felt the scope
Cact
in
PMRGCAuk
2 years ago
Some advice
Hello, I don't really know how to start off. Around a year ago I was diagnosed with primary dysmenorrhea. I have been suffering with pain and fatigue since I was 11 when I first got my period. I was given birth control and regularly take a series of medications to help me somewhat function during my
Hello, I don't really know how to start off. Around a year ago I was diagnosed with primary dysmenorrhea. I have been suffering with pain and fatigue since I was 11 when I first got my period. I was given birth control and regularly take a series of medications to help me somewhat function during my
thealevelstudent
in
Endometriosis UK
2 years ago
Faistula Discoloration
I am a 73 yr old Afo American female and after using lidocaine plus 4% for the pin of needle stick the last 3 years I was prescribed lidocaine 2.5% and prilocaine cream 2.5% after 2 uses the area looked as if I was burned including blisters, discontinued use and went back to the Salonpas but it looks
I am a 73 yr old Afo American female and after using lidocaine plus 4% for the pin of needle stick the last 3 years I was prescribed lidocaine 2.5% and prilocaine cream 2.5% after 2 uses the area looked as if I was burned including blisters, discontinued use and went back to the Salonpas but it looks
Pgraduate
in
Kidney Dialysis
2 years ago
just started Alendronic Acid tablets
I was recently diagnosed with osteoporosis and given alendonic accid tablets to try. The day after I took them my teeth on one side felt weird, more prominent somehow. I'm wondering if this is normal or a problem. Have asked my dentist for advice but wondered if anyone else experienced this?
I was recently diagnosed with osteoporosis and given alendonic accid tablets to try. The day after I took them my teeth on one side felt weird, more prominent somehow. I'm wondering if this is normal or a problem. Have asked my dentist for advice but wondered if anyone else experienced this?
Padster60
in
Bone Health and Osteoporosis UK
2 years ago
Interesting discussion on supplements from ZOE
Here is a podcast or transcript of it that others may find useful in deciding what to spend their precious pennies on after an expert discusses large, long range studies. For those who have neither the time nor the brain today, it was a thumbs up to a multivitamin, vitamin D (not large doses!), omega
Here is a podcast or transcript of it that others may find useful in deciding what to spend their precious pennies on after an expert discusses large, long range studies. For those who have neither the time nor the brain today, it was a thumbs up to a multivitamin, vitamin D (not large doses!), omega
SnazzyD
in
PMRGCAuk
2 years ago
Advice Needed Please on Medichecks Results
CRP 1 (1921) 3.57 (1922) Range: 0-5 Ferritin 84 (1921) 101 (1922) Range: 13-150 Folate 7.2 (1921) 5.59 (1922) Range 3.89-1045 B12 Active 242 (1921) 150 (1922) Range 37.5-150 Vit D 142 (1921) 102 (1922) Range: 50-200) TSH 0.01 (1921) 0.23 (1922) Range:
CRP 1 (1921) 3.57 (1922) Range: 0-5 Ferritin 84 (1921) 101 (1922) Range: 13-150 Folate 7.2 (1921) 5.59 (1922) Range 3.89-1045 B12 Active 242 (1921) 150 (1922) Range 37.5-150 Vit D 142 (1921) 102 (1922) Range: 50-200) TSH 0.01 (1921) 0.23 (1922) Range:
Delgor
in
Thyroid UK
2 years ago
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
In 2010, Hashimoto’s team has hijacked cIAP1-E3 ligase using bestatin-methyl ester MeBS and used all-trans
retinoic
acid
(ATRA) as a warhead to develop the first cIAP1-based PROTAC (compounds 4) to degrade cellular
retinoic
acid
binding protein (CRABP-I/-II) (Itoh et al., 2010).
In 2010, Hashimoto’s team has hijacked cIAP1-E3 ligase using bestatin-methyl ester MeBS and used all-trans
retinoic
acid
(ATRA) as a warhead to develop the first cIAP1-based PROTAC (compounds 4) to degrade cellular
retinoic
acid
binding protein (CRABP-I/-II) (Itoh et al., 2010).
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Second Prostap injection
Hi, I had my second 3 month Prostap injection 4 weeks ago and I’ve been bleeding heavily with clots since having it… it took 6 weeks for the bleeding to stop when I had the first one, then I had a few weeks of no bleeding which was lovely, I started spotting two weeks before my second was due but assumed
Hi, I had my second 3 month Prostap injection 4 weeks ago and I’ve been bleeding heavily with clots since having it… it took 6 weeks for the bleeding to stop when I had the first one, then I had a few weeks of no bleeding which was lovely, I started spotting two weeks before my second was due but assumed
Louise_Jane77
in
Endometriosis UK
2 years ago
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