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New hope for castrate resistant prostate cancer on the horizon
A new experimental drug is in development that reverses castrate resistance and makes the cancer amenable to further treatment. Early days yet but it looks interesting. https://www.theguardian.com/society/2023/oct/16/new-prostate-cancer-treatment-may-be-on-the-horizon-say-scientists
A new experimental drug is in development that reverses castrate resistance and makes the cancer amenable to further treatment. Early days yet but it looks interesting. https://www.theguardian.com/society/2023/oct/16/new-prostate-cancer-treatment-may-be-on-the-horizon-say-scientists
GeorgesCalvez
in
Advanced Prostate Cancer
7 months ago
The Science is Coming
Good to see the mini AZD5069 trial with enzalutamide offering another route to taming the beast. I am no scientist but as I understand it the target is myeloid white blood cells which can act to fuel tumours. The drup blocks the CXCR2 receptor and, in a small sample seems to have resulted in tumour shrinkage
Good to see the mini AZD5069 trial with enzalutamide offering another route to taming the beast. I am no scientist but as I understand it the target is myeloid white blood cells which can act to fuel tumours. The drup blocks the CXCR2 receptor and, in a small sample seems to have resulted in tumour shrinkage
GreenStreet
in
Prostate Cancer Network
7 months ago
FDG+/PSMA- lesions
My dad has metastatic CRPC. Xtandi failed, but at the moment he is still on it as we evaluate possible treatment options. Today we received also results of PSMA PET CT - it it stated, that there are discrepancies (loss of PSMA expression) with at least 4 bone mets when compared to findings of FDG (
My dad has metastatic CRPC. Xtandi failed, but at the moment he is still on it as we evaluate possible treatment options. Today we received also results of PSMA PET CT - it it stated, that there are discrepancies (loss of PSMA expression) with at least 4 bone mets when compared to findings of FDG (
MyDad76
in
Advanced Prostate Cancer
7 months ago
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MSK Consult Today
Thanks to everyone who has given me excellent advice regarding my husband’s pca recurrence. Today we met with an MSK uro oncologist for a second opinion. He completely agreed and supported the plan of radiating the high pelvic nodes (including the lower abdominal nodes along the bifurcation) and slightly
Thanks to everyone who has given me excellent advice regarding my husband’s pca recurrence. Today we met with an MSK uro oncologist for a second opinion. He completely agreed and supported the plan of radiating the high pelvic nodes (including the lower abdominal nodes along the bifurcation) and slightly
103532
in
Advanced Prostate Cancer
4 months ago
Do I need an Oncologist?
Originally had PSA test that came back 28+ and was referred to Urologist. I was not interested in Surgery so the Urologist referred me to a Radiation Oncologist. After the radiation treatments were over I went back to the Urologist to continue the Lupron treatments. My last visit with the Radiation Team
Originally had PSA test that came back 28+ and was referred to Urologist. I was not interested in Surgery so the Urologist referred me to a Radiation Oncologist. After the radiation treatments were over I went back to the Urologist to continue the Lupron treatments. My last visit with the Radiation Team
johnson2691
in
Advanced Prostate Cancer
4 months ago
PSA test at a different lab
I will be spending the winter in Florida. I have always had my PSA tested in Boston at the same medical facility for the last 7 years. In a perfect world I would travel back to Boston for a few day. Any feedback would be appreciated Thanks
I will be spending the winter in Florida. I have always had my PSA tested in Boston at the same medical facility for the last 7 years. In a perfect world I would travel back to Boston for a few day. Any feedback would be appreciated Thanks
Rfs1975
in
Advanced Prostate Cancer
4 months ago
PSA test at a different lab
I will be spending the winter in Florida. I have always had my PSA tested in Boston at the same medical facility for the last 7 years. In a perfect world I would travel back to Boston for a few day. Any feedback would be appreciated Thanks
I will be spending the winter in Florida. I have always had my PSA tested in Boston at the same medical facility for the last 7 years. In a perfect world I would travel back to Boston for a few day. Any feedback would be appreciated Thanks
Rfs1975
in
Advanced Prostate Cancer
4 months ago
PSA suppression
My PSA lows tend to be around 3.3, and it occurs to me that some might think it odd that I don't drive it lower. I think it is very common for men on ADT to draw too much comfort from a significant PSA reduction, if not a near-zero PSA. I have witnessed men misinterpret a dramatic drop in PSA as
My PSA lows tend to be around 3.3, and it occurs to me that some might think it odd that I don't drive it lower. I think it is very common for men on ADT to draw too much comfort from a significant PSA reduction, if not a near-zero PSA. I have witnessed men misinterpret a dramatic drop in PSA as
pca2004
in
Fight Prostate Cancer
4 months ago
Questions
I saw my PSA suddenly rise to 3.67 in January 2023. My PMD was not overly concerned as it was under 4. His plan was to repeat it in 6 months. I will also not I was on Tamsulosin and Finasteride for some time at that point for urinary frequency. That started several years before (at that time I was
I saw my PSA suddenly rise to 3.67 in January 2023. My PMD was not overly concerned as it was under 4. His plan was to repeat it in 6 months. I will also not I was on Tamsulosin and Finasteride for some time at that point for urinary frequency. That started several years before (at that time I was
Cleantop
in
Advanced Prostate Cancer
4 months ago
bicalutamide no longer as effective?
After more than two years of bicalutamide monotherapy and repeated PSA<0.1 I just received a 0.6. Before the bicalutamide my PSMA scan showed activity in only the seminal vesicle region. PSA was 2.5 at that time. Lupron had ceased being effective. Bicalutamide had a terrific response. I don’t think PSMA
After more than two years of bicalutamide monotherapy and repeated PSA<0.1 I just received a 0.6. Before the bicalutamide my PSMA scan showed activity in only the seminal vesicle region. PSA was 2.5 at that time. Lupron had ceased being effective. Bicalutamide had a terrific response. I don’t think PSMA
kreg001
in
Advanced Prostate Cancer
6 months ago
Elevated PSA 8 weeks after Robotic Prostatectomy
At the age of 70 my most recent treatment was a Robotic Prostatectomy after which pathology report was Gl 3+4 prostate cancer, pT3a (EPE and bladder neck invasion), N1 (1/15 nodes positive), multiple positive margins.( Prior to that I underwent Cryotherapy for prostate cancer in Mar 2012.) My PSA level
At the age of 70 my most recent treatment was a Robotic Prostatectomy after which pathology report was Gl 3+4 prostate cancer, pT3a (EPE and bladder neck invasion), N1 (1/15 nodes positive), multiple positive margins.( Prior to that I underwent Cryotherapy for prostate cancer in Mar 2012.) My PSA level
OLDSALTY2008
in
Advanced Prostate Cancer
6 months ago
ADT SE’s
I had a 6 month Lupron shot in April last year. I experienced all the typical SE the worst being the hot flashes at night. I am following the Ssport protocol for a biological reoccurrence. Basically a 6 month adt with 39 radiation treatments last year. Current labs show undetectable PSA with a slow
I had a 6 month Lupron shot in April last year. I experienced all the typical SE the worst being the hot flashes at night. I am following the Ssport protocol for a biological reoccurrence. Basically a 6 month adt with 39 radiation treatments last year. Current labs show undetectable PSA with a slow
plato123
in
Advanced Prostate Cancer
5 months ago
Recent PSA test result no longer “undetectable.” What’s next?
After 5+ years of measuring “undetectable” with my PSA results I recently measured 0.24 NG/ML which I’m assuming my PCA is becoming active again. I see my oncologist on Monday, 8 Jan for a follow-up appt. Can anyone share with me what the likely next course of action will be?
After 5+ years of measuring “undetectable” with my PSA results I recently measured 0.24 NG/ML which I’m assuming my PCA is becoming active again. I see my oncologist on Monday, 8 Jan for a follow-up appt. Can anyone share with me what the likely next course of action will be?
Woodman33
in
Advanced Prostate Cancer
5 months ago
Signatera tumor dna test
Has anyone heard of using the Signatera test from Natera to detect the presence of prostate cancer recurrence when PSA is rising but the PSMA PET scan is negative?
Has anyone heard of using the Signatera test from Natera to detect the presence of prostate cancer recurrence when PSA is rising but the PSMA PET scan is negative?
shihtzu124
in
Advanced Prostate Cancer
6 months ago
PSA Dropped after 22 days of Zytiga
On Nov 1, my cancer was diagnosed as castrate resistant. Abiraterone and Prednisone was added to Lupron. On November 3 I had a Lupron shot and started Abiraterone and Prednisone on November 10. Today I had a PSA test. My PSA dropped from 0.8 on November 1 to 0.44 today. I was not expecting such dramatic
On Nov 1, my cancer was diagnosed as castrate resistant. Abiraterone and Prednisone was added to Lupron. On November 3 I had a Lupron shot and started Abiraterone and Prednisone on November 10. Today I had a PSA test. My PSA dropped from 0.8 on November 1 to 0.44 today. I was not expecting such dramatic
dac500
in
Advanced Prostate Cancer
6 months ago
Happy New Year and Update
Update: I took what I hope will be my last Lupron shot which will work until March 5 /24. I will have had 31 months of Lupron with mostly undetectable PSA. I will have had 29 months of Abiraterone at that point. Had IMRT radiation 24 months ago Both my MO and RO are interested in whether they have
Update: I took what I hope will be my last Lupron shot which will work until March 5 /24. I will have had 31 months of Lupron with mostly undetectable PSA. I will have had 29 months of Abiraterone at that point. Had IMRT radiation 24 months ago Both my MO and RO are interested in whether they have
Scout4answers
in
Advanced Prostate Cancer
5 months ago
What’s after Lu-177 in Vancouver, BC?
Hi there, I’m located in Vancouver, BC 🇨🇦. My dad is on a clinical trial and after over a decade with this disease he has failed Zytiga, Xtandi, docetaxel, and is now on his 4/6 Lu-177 infusion. He’s castration-resistant and metastatic. PSA decreased considerably after the first Lu-177 infusion but
Hi there, I’m located in Vancouver, BC 🇨🇦. My dad is on a clinical trial and after over a decade with this disease he has failed Zytiga, Xtandi, docetaxel, and is now on his 4/6 Lu-177 infusion. He’s castration-resistant and metastatic. PSA decreased considerably after the first Lu-177 infusion but
PHnerd
in
Advanced Prostate Cancer
5 months ago
Rising PSA 1 year after RALP
I've been getting ultra sensitive PSA tests every three months. These are the last three scores: 0.015 0.017 0.026 (First PSA test after surgery was <0.1) I am worried. Frightened, actually. Margins were not clear on my surgical biopsy, though gleason was only 3+3. Two biopsies prior
I've been getting ultra sensitive PSA tests every three months. These are the last three scores: 0.015 0.017 0.026 (First PSA test after surgery was <0.1) I am worried. Frightened, actually. Margins were not clear on my surgical biopsy, though gleason was only 3+3. Two biopsies prior
SmasherOfAjumma
in
Prostate Cancer Network
5 months ago
PSA Bounce
Hello and happy New year distinguished gentlemen. I was wondering if I may please get your input on my latest PSA which bounced from 1.2 to 1.6. Why did this happen and is this something I should be concerned about? Thanks so much. Regards.
Hello and happy New year distinguished gentlemen. I was wondering if I may please get your input on my latest PSA which bounced from 1.2 to 1.6. Why did this happen and is this something I should be concerned about? Thanks so much. Regards.
caysary
in
Advanced Prostate Cancer
5 months ago
Low Volume Low PSA Metastatic PC.
When my Oncologist refers to Low volume, Low PSA Oglimetastic PC, what is he saying about my disease? I’ve been oo Abiraterone followed by Xtandi with Lupron every 3 months and Zometa every 6.
When my Oncologist refers to Low volume, Low PSA Oglimetastic PC, what is he saying about my disease? I’ve been oo Abiraterone followed by Xtandi with Lupron every 3 months and Zometa every 6.
NDJIM
in
Advanced Prostate Cancer
6 months ago
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