PSA Dropped after 22 days of Zytiga

[dac500]

On Nov 1, my cancer was diagnosed as castrate resistant. Abiraterone and Prednisone was added to Lupron. On November 3 I had a Lupron shot and started Abiraterone and Prednisone on November 10. Today I had a PSA test. My PSA dropped from 0.8 on November 1 to 0.44 today. I was not expecting such dramatic fall in PSA after only 22 days of Abiraterone . I will have another PSA test on January 4. Should I expect further fall in PSA?

[Hidden]

Yes, another fall should be on the way. When I started Abiraterone, it took a year for my PSA to fall to <0.1. It's currently at 0.012.

Best of luck, Marshall.

[Tall_Allen]

Congratulations!

[Lettuce231]

That's the kind of result we all dream of, excellent news. There's no reason to think that it won't continue to fall again or again after that.

Wishing you all the best and a good Christmas 🎄 😊

[Chrisbaird]

Original PSA 23…stage 3 been on zytiga ( 500 gms) prednisone (5gms) daily ..hormone shot every 3 months for last 3 years …past 2.5 years undetectable PCA with no other treatment hope Dac 500 things go as well for you

[Chrisbaird]

side effects though …lack of energy sleep 11 hours average daily no water problems. Summer months hot sweats bad. Wake sweating in night mostly use fan to cool down

[pakb]

Congrats! I hope the great response continues for you!My husband has been on lupron, zytiga plus prednisone for 5.5 years after he finished his first treatment after diagnosis (Gleason 9 nets to several bones). 1st treatment was lupron and 6 rounds chemo. His PSA still continues a slow downward trend from over 677 to start to 0.5 as of yesterday. It took almost 6 years to get below 1- and despite a few small upticks once in a while it keeps going down. His side effects (besides usual ADT ED) are a bit more fatigue and hot flashes (most hot flashes were in the beginning of treatment- they've really almost disappeared). He keeps busy working, working out and keeping up with our kids- now in their 20s.

[joeydashoe]

Yes, And A quick drop I'm told is a good sign, Congrats.

[Professorgary]

mine dropped from 19.4 to 4.69 in 25 days and then to 2.7 after another month. That was Nov. 8. Next test Jan. 11. I am on low dose with food. I am also taking 5 mg prednisone instead of 10 mg daily. From my research I have found that a 50% drop in the first month is a good indicator. Best of luck, God bless.

[LongTimeRunning]

Mine went from 49 (or more if it was rising before getting on meds 2 weeks after measurement) to 8.3 in about 2 weeks and to < 1 in about 2 months (total). Started with 10mg pred, dropped to 5mg few months later and have been stable undetectable (<0.02) PSA since (last 5 months).