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Any proof that removing a tumor off prostate bed by radiation or surgery is better than just systemic therapy ?
Here is my history PSA rising now 0.77 Going for pet scan tomorrow Tumour on prostate bed had Radical Prostatectomy with Lymph node removal 03/2023 Stage 4 Oligo Metastatic Prostate Cancer Original PSA 942.40 at diagnosis 06/2022 Gleason 8 / 9 ductal without large cribform gland, cT3b
Here is my history PSA rising now 0.77 Going for pet scan tomorrow Tumour on prostate bed had Radical Prostatectomy with Lymph node removal 03/2023 Stage 4 Oligo Metastatic Prostate Cancer Original PSA 942.40 at diagnosis 06/2022 Gleason 8 / 9 ductal without large cribform gland, cT3b
Shorehousejam
in
Advanced Prostate Cancer
4 months ago
LUPRON CASODEX FAILURE NOW WHAT
After 26 years, my combo IHT has finally failed. My psa started to go up while unicycle-a first, in November, pas rose to 8, since then and after a disaster of my cancer set up here, my pas has gone to 20. My testosterone has gone up from around 3 max to over 9 so no idea how or why this happened while
After 26 years, my combo IHT has finally failed. My psa started to go up while unicycle-a first, in November, pas rose to 8, since then and after a disaster of my cancer set up here, my pas has gone to 20. My testosterone has gone up from around 3 max to over 9 so no idea how or why this happened while
billyboy3
in
Advanced Prostate Cancer
2 months ago
HELP NEEDED
First, as one of the longest living men with prostate cancer, I will update you. in 1997, I was disanosted with PC, having a Gleeson 7 later upgraded to an 8 but who cares, my pas was 4.9 at this time. I had my prostate out in 1998, reoccurrence by way of psa went up t o5.5. Surgery was done, all was
First, as one of the longest living men with prostate cancer, I will update you. in 1997, I was disanosted with PC, having a Gleeson 7 later upgraded to an 8 but who cares, my pas was 4.9 at this time. I had my prostate out in 1998, reoccurrence by way of psa went up t o5.5. Surgery was done, all was
billyboy3
in
Advanced Prostate Cancer
2 months ago
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Transdermal estrogen/estradiol as monotherapy for Prostate Cancer
Does anyone know of recent studies, clinical trials or Standard of Care (SoC) protocols using or studying estrogen gels, sprays, ointments or patches as hormone therapy for Prostate Cancer, particularly micrometastatic cancer that has not spread beyond the pelvic region? I am in discussions with my
Does anyone know of recent studies, clinical trials or Standard of Care (SoC) protocols using or studying estrogen gels, sprays, ointments or patches as hormone therapy for Prostate Cancer, particularly micrometastatic cancer that has not spread beyond the pelvic region? I am in discussions with my
Lost_Sheep
in
Prostate Cancer Network
6 months ago
Nubeqa vs Zytiga?
Hi all, got notice last evening that Nubeqa will no longer be covered by my drug provider. Apologies I should have said this in original post: What happened is Nova Scotia just in February approved Nubeqa, this then means that I would have to apply for my insurance to cover it INSTEAD of the compassion
Hi all, got notice last evening that Nubeqa will no longer be covered by my drug provider. Apologies I should have said this in original post: What happened is Nova Scotia just in February approved Nubeqa, this then means that I would have to apply for my insurance to cover it INSTEAD of the compassion
Yzinger
in
Advanced Prostate Cancer
2 months ago
Initial Phase 1 Data on MB-105 for Patients with PSCA-positive Castration Resistant Prostate Cancer
From what I understand PSCA is highly expressed in prostate cancer cells but also in other kinds of cancer and also in other tissues (in small amounts), and its production increases as the disease progresses, making it a better target for later stages (but this is my speculation!). What is important
From what I understand PSCA is highly expressed in prostate cancer cells but also in other kinds of cancer and also in other tissues (in small amounts), and its production increases as the disease progresses, making it a better target for later stages (but this is my speculation!). What is important
Maxone73
in
Advanced Prostate Cancer
4 months ago
ALT and AST levels
Hi all! I'll begin by thanking everyone on this site for the invaluable information I've found here. I'm Gleason 9, very high risk, localized pca. In Jan/Feb I rec'd 5 treatments of SBRT and have been on Lupron and Abiraterone/prednisone for the past 7 months. Just had labs done, and psa is at 0.1. The
Hi all! I'll begin by thanking everyone on this site for the invaluable information I've found here. I'm Gleason 9, very high risk, localized pca. In Jan/Feb I rec'd 5 treatments of SBRT and have been on Lupron and Abiraterone/prednisone for the past 7 months. Just had labs done, and psa is at 0.1. The
Quarky
in
Advanced Prostate Cancer
2 months ago
PSA undetectable
After surgery PSA should be undetectable. What does it mean. Once the lab give 0.03, once 0.04. I guess it s the lab (standard error of the machine), but what is the limit of the lab and when should i consider that THERE IS a PSA. Why is PSA still detectable after surgery should nt it be 0.00 ?
After surgery PSA should be undetectable. What does it mean. Once the lab give 0.03, once 0.04. I guess it s the lab (standard error of the machine), but what is the limit of the lab and when should i consider that THERE IS a PSA. Why is PSA still detectable after surgery should nt it be 0.00 ?
cpl901
in
Advanced Prostate Cancer
2 months ago
CONTACT-02 Phase III: Cabozantinib-Atezolizumab combination works well in mCRPC with soft tissue metastasis
"The trial's rigorous methodology and the promising results, particularly in high-risk groups with liver metastasis, offer a beacon of hope for a patient population with limited treatment options. " "There was a 57% reduction in risk of progression or death in patients with liver metastasis with cabo
"The trial's rigorous methodology and the promising results, particularly in high-risk groups with liver metastasis, offer a beacon of hope for a patient population with limited treatment options. " "There was a 57% reduction in risk of progression or death in patients with liver metastasis with cabo
Maxone73
in
Advanced Prostate Cancer
6 months ago
Testosterone Recovery for 50% of Men
Here's an updated plot of Testosterone recovery time for 50% of men after stopping Lupron ADT, as a function of ADT duration. For ADT durations less than 20 months, the curve is basically linear with a slope = 1.0 (green line), meaning that the Recovery Time for 50% of men is roughly equal to the ADT
Here's an updated plot of Testosterone recovery time for 50% of men after stopping Lupron ADT, as a function of ADT duration. For ADT durations less than 20 months, the curve is basically linear with a slope = 1.0 (green line), meaning that the Recovery Time for 50% of men is roughly equal to the ADT
janebob99
in
Prostate Cancer Network
6 months ago
Methionine restricted diet for recurring PSA and positive PMSA pet scan w/ 1 bone met
quick to the point. PSMA pet showed 1 L2 small met and some lymph activity. My PSA went from 2.01 to 2.9 in one month. after doing some research on diets and supplements . I found that the keto diet is extremely high in the amino acid methionine and I made it worse trying to reduce my blood pressure
quick to the point. PSMA pet showed 1 L2 small met and some lymph activity. My PSA went from 2.01 to 2.9 in one month. after doing some research on diets and supplements . I found that the keto diet is extremely high in the amino acid methionine and I made it worse trying to reduce my blood pressure
Eieio
in
Advanced Prostate Cancer
3 months ago
If PSA is Suppressed by Doublet ADT, Will Salvage IMRT Cause a PSA Rise?
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
103532
in
Advanced Prostate Cancer
4 months ago
PSA continues rise...PSMA remains good
To briefly review, now 69 years old, had RP at Hopkins in Feb 2018. Gleason 4+5. Margins clear. Organ-confined. PSA undetectable for two years...then an ill-advised and reckless PSA holiday for three years until Aug 2023 when PSA measured in the range of 7. First PSMA that same month entirely negative
To briefly review, now 69 years old, had RP at Hopkins in Feb 2018. Gleason 4+5. Margins clear. Organ-confined. PSA undetectable for two years...then an ill-advised and reckless PSA holiday for three years until Aug 2023 when PSA measured in the range of 7. First PSMA that same month entirely negative
Nittany
in
Prostate Cancer Network
3 months ago
A Phase 1, Open-Label, Multicenter Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer
I have a choice between this trial and a BAT trial. I’m already preferential to BAT, but without being too hasty, I wanted to see if anyone here has any experience with JANX00x before deciding.
I have a choice between this trial and a BAT trial. I’m already preferential to BAT, but without being too hasty, I wanted to see if anyone here has any experience with JANX00x before deciding.
No_stone_unturned
in
Advanced Prostate Cancer
6 months ago
Docetaxel Failing
Greetings from Inverness in the beautiful Highlands of Scotland! I would like to share my journey with you and hopefully get some advice on future treatments. In December 2022 following diagnoses of advanced prostate cancer with multiple bone metastasis I started zytiga + prednisone and 6 monthly triptorelin
Greetings from Inverness in the beautiful Highlands of Scotland! I would like to share my journey with you and hopefully get some advice on future treatments. In December 2022 following diagnoses of advanced prostate cancer with multiple bone metastasis I started zytiga + prednisone and 6 monthly triptorelin
Fisherman2
in
Advanced Prostate Cancer
4 months ago
PSA Still Going Up
I had RP on January 2023, started ADT in May 2023 and went through 38 sessions of radiation. In November 2023, my PSA went down to 0.005 ng/mL. My PSA went up to 0.015 ng/mL in January 2024 and went up to 0.035 ng/mL in my current test. I know Tall Allen said the previous number was negligible because
I had RP on January 2023, started ADT in May 2023 and went through 38 sessions of radiation. In November 2023, my PSA went down to 0.005 ng/mL. My PSA went up to 0.015 ng/mL in January 2024 and went up to 0.035 ng/mL in my current test. I know Tall Allen said the previous number was negligible because
toyman79912
in
Advanced Prostate Cancer
3 months ago
Some Prostate Cancer Medical Practitioners on a Chart - 2024
Advanced Prostate Cancer Consensus Conference (APCCC) 2024
You decide if you think they're any good or not. ----- Previous title history, changed due to inaccuracies or controversies: 1. Worlds top Medical Oncologists -2024 2. Worlds top Prostate Cancer Medical Practioners - 2024 3. Some
Advanced Prostate Cancer Consensus Conference (APCCC) 2024
You decide if you think they're any good or not. ----- Previous title history, changed due to inaccuracies or controversies: 1. Worlds top Medical Oncologists -2024 2. Worlds top Prostate Cancer Medical Practioners - 2024 3. Some
skiingfiend
in
Advanced Prostate Cancer
6 months ago
PSA 8 months after EBRT
I need some reassurance. I tend to worry a little bit so please let me know if the following is or could be somewhat normal. As per my history, I had 4+3 per Dr. Epstein, had Pylarify with no mets, seed implant LD brachytherapy in July 2023, EBRT 28 treatments finishing first of Oct 2023. RO said ADT
I need some reassurance. I tend to worry a little bit so please let me know if the following is or could be somewhat normal. As per my history, I had 4+3 per Dr. Epstein, had Pylarify with no mets, seed implant LD brachytherapy in July 2023, EBRT 28 treatments finishing first of Oct 2023. RO said ADT
electronics-guy
in
Prostate Cancer Network
3 months ago
Falling ALT - Pathway to Sarcopenia? - More Exercise Needed?
Two years in to my de novo high volume metastatic prostate cancer diagnosis, I am pleased to report excellent results so far with triplet therapy (Docetaxel chemo completed, Abiraterone ARPI, Firmagon/Degarelix GnRH antagonist as ADT). However I would be grateful for any advice today.
My ALT has fallen
Two years in to my de novo high volume metastatic prostate cancer diagnosis, I am pleased to report excellent results so far with triplet therapy (Docetaxel chemo completed, Abiraterone ARPI, Firmagon/Degarelix GnRH antagonist as ADT). However I would be grateful for any advice today.
My ALT has fallen
JohnInTheMiddle
in
Advanced Prostate Cancer
3 months ago
Appropriate Treatment
I was diagnosed with stage 4 prostate cancer PSA 29.1 which had metastatised to lymph nodes, ribs & spine after a few months on Abiraterone and Prednisone my PSA count dropped to 0.06 After 30 months my PSA started to rise at 10.2 my treatment was declared ineffective Lutetium 177 treatment was recommended
I was diagnosed with stage 4 prostate cancer PSA 29.1 which had metastatised to lymph nodes, ribs & spine after a few months on Abiraterone and Prednisone my PSA count dropped to 0.06 After 30 months my PSA started to rise at 10.2 my treatment was declared ineffective Lutetium 177 treatment was recommended
154Eleventh
in
Advanced Prostate Cancer
4 months ago
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