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Calquence / acalabrutinib and Brukinsa / zanubrutinib Adverse Event Comparison for Chronic Lymphocytic Leukaemia / CLL from clinical trials
Now that we have a growing choice of BTK inhibitor treatment options, naturally the question is which one is better? Based on this meta-analysis study of the incidence of 84 Adverse Events (AEs) reported in 61 clinical trials involving nearly 7,000 patients, that question should be better framed as
Now that we have a growing choice of BTK inhibitor treatment options, naturally the question is which one is better? Based on this meta-analysis study of the incidence of 84 Adverse Events (AEs) reported in 61 clinical trials involving nearly 7,000 patients, that question should be better framed as
AussieNeil
Partner
in
CLL Support
1 year ago
BIOMARKER TESTING
My wife has extensive small cell lung cancer (SCLC-E) and has undergone chemotherapy, immunotherapy and radiotherapy. Her lung tumor is currently stable and I want to get options if her current immunotherapy (atezolizumab every three weeks) becomes ineffective. There are several chemotherapy options
My wife has extensive small cell lung cancer (SCLC-E) and has undergone chemotherapy, immunotherapy and radiotherapy. Her lung tumor is currently stable and I want to get options if her current immunotherapy (atezolizumab every three weeks) becomes ineffective. There are several chemotherapy options
Info911
in
The Roy Castle Lung Cancer Foundation
1 year ago
The 2023 update of "Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline" is now available.
For those unfamiliar with this annual report, a good place to start might be Fig. 2 in the RESULTS section (a colour-coded diagram). https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd239901
For those unfamiliar with this annual report, a good place to start might be Fig. 2 in the RESULTS section (a colour-coded diagram). https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd239901
jeffreyn
in
Cure Parkinson's
1 year ago
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Where do I go from here?
Hi lovely ladies. Ok, so, diagnosed April 2021 Stage 1V HGSOC with spread to lymph nodes in neck and chest. No option of surgery because of spread. 6 rounds of Paclitaxel/Carboplatin. Reduction in tumour. Straight on to Avastin plus Olaparib (HRD negative). No more cancer in lymph nodes but slight progression
Hi lovely ladies. Ok, so, diagnosed April 2021 Stage 1V HGSOC with spread to lymph nodes in neck and chest. No option of surgery because of spread. 6 rounds of Paclitaxel/Carboplatin. Reduction in tumour. Straight on to Avastin plus Olaparib (HRD negative). No more cancer in lymph nodes but slight progression
Guilane
in
My Ovacome
1 year ago
Clinical Trials
Hello Just wondering if anyone has considered clinical trials? I volunteered for this one vhttps://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=31552&location=&distance= One more visit then back in a year's time to repeat again, the information is on the MSA webpage. Truthfully
Hello Just wondering if anyone has considered clinical trials? I volunteered for this one vhttps://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=31552&location=&distance= One more visit then back in a year's time to repeat again, the information is on the MSA webpage. Truthfully
esj20
in
Multiple System Atrophy Trust
1 year ago
Phase 3 SONIA Trial Challenges the Routine Practice of Using a 1st Line CDK4/6 Inhibitor in HR+, HER2- MBC
Apologies for the length, but I thought you might find this interesting! from: https://dailynews.ascopubs.org/do/sonia-challenges-need-first-line-use-cdk4-6-inhibitor-hr-positive-her2-negative?utm_source=newsletter&utm_medium=email&utm_campaign=The+OncoAlert+Newsletter+DAY+4+ASCO+2023&cmid=14f595bb-abce
Apologies for the length, but I thought you might find this interesting! from: https://dailynews.ascopubs.org/do/sonia-challenges-need-first-line-use-cdk4-6-inhibitor-hr-positive-her2-negative?utm_source=newsletter&utm_medium=email&utm_campaign=The+OncoAlert+Newsletter+DAY+4+ASCO+2023&cmid=14f595bb-abce
Bestbird
in
SHARE Metastatic Breast Cancer
1 year ago
PSMA PET scans
I am currently undergoing SBRT to three mets in my upper right lung as part of the comet 3 clinical trial. I would like to know how long I should wait before getting a PSMA PET scan I stopped taking Xtandi 2 weeks before treatment and will not start taking it again until 2 weeks after treatment
I am currently undergoing SBRT to three mets in my upper right lung as part of the comet 3 clinical trial. I would like to know how long I should wait before getting a PSMA PET scan I stopped taking Xtandi 2 weeks before treatment and will not start taking it again until 2 weeks after treatment
Ian996
in
Advanced Prostate Cancer
1 year ago
Biogen has disclosed plans to stop a late-stage clinical trial testing one of its drugs as a potential treatment for Parkinson's disease
The reasons are very absurd such as: According to a Monday announcement, the decision is due to several factors, including the trial’s complexity and run time. Results weren’t expected to come in until early 2031. Another, ongoing study evaluating the drug in early Parkinson’s patients will continue
The reasons are very absurd such as: According to a Monday announcement, the decision is due to several factors, including the trial’s complexity and run time. Results weren’t expected to come in until early 2031. Another, ongoing study evaluating the drug in early Parkinson’s patients will continue
Farooqji
in
Cure Parkinson's
1 year ago
More from PubMed
1. Magnetic resonance imaging (MRI) for local staging before salvage radical prostatectomy: a meta-analysis. Zapała P, Ślusarczyk A, Rajwa P, Gandaglia G, Zapała Ł, Zattoni F, Lorenc T, Ploussard G, Radziszewski P. World J Urol. 2023 May;41(5):1275-1284. doi: 10.1007/s00345-023-04383-2. Epub 2023 Apr
1. Magnetic resonance imaging (MRI) for local staging before salvage radical prostatectomy: a meta-analysis. Zapała P, Ślusarczyk A, Rajwa P, Gandaglia G, Zapała Ł, Zattoni F, Lorenc T, Ploussard G, Radziszewski P. World J Urol. 2023 May;41(5):1275-1284. doi: 10.1007/s00345-023-04383-2. Epub 2023 Apr
Magnus1964
in
Advanced Prostate Cancer
1 year ago
Latest from PubMed
1. Efficacy in urinary symptom burden, psychological distress, and self-efficacy of education-enhanced interventions in prostate cancer patients: a systematic review and meta-analyses. Martín-Núñez J, Raya-Benítez J, López-López L, Calvache-Mateo A, Heredia-Ciuró A, Navas-Otero A, Valenza MC. Support
1. Efficacy in urinary symptom burden, psychological distress, and self-efficacy of education-enhanced interventions in prostate cancer patients: a systematic review and meta-analyses. Martín-Núñez J, Raya-Benítez J, López-López L, Calvache-Mateo A, Heredia-Ciuró A, Navas-Otero A, Valenza MC. Support
Magnus1964
in
Advanced Prostate Cancer
1 year ago
Success in a Phase 2 trial of umbilical-cord-derived allogeneic mesenchymal stromal cells (MSCs) for newly diagnosed Type 1 diabetes.
"No other treatments on the market or in clinical trials have shown the ability to halt the progression of diabetes." Medical Xpress article: Wharton's jelly found to halt diabetes progression in Phase II trial. https://medicalxpress.com/news/2023-06-wharton-jelly-halt-diabetes-phase.html Research
"No other treatments on the market or in clinical trials have shown the ability to halt the progression of diabetes." Medical Xpress article: Wharton's jelly found to halt diabetes progression in Phase II trial. https://medicalxpress.com/news/2023-06-wharton-jelly-halt-diabetes-phase.html Research
jeffreyn
in
Cure Parkinson's
1 year ago
A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation, eLife, Review Article, Mar 23, 2023
For those wanting to do a deep dive into Adaptive Theory, this survey paper is the current master document to do so. It includes the major researchers affiliated with Moffitt and others from around the globe and, as the title indicates, addresses current questions about applying these principles into
For those wanting to do a deep dive into Adaptive Theory, this survey paper is the current master document to do so. It includes the major researchers affiliated with Moffitt and others from around the globe and, as the title indicates, addresses current questions about applying these principles into
cujoe
in
Fight Prostate Cancer
1 year ago
Last chance saloon or what?
My most recent PSA score went up to 9.04 from 2.45 in March, 2.14 in January 1.05 in November and it was 0.61 in August. I finished Docetaxyl chemotherapy on 7th Septemb er last year so I've only been on Prostap with prednisolone since then. My onco says he will arrange urgent bone scan and full body
My most recent PSA score went up to 9.04 from 2.45 in March, 2.14 in January 1.05 in November and it was 0.61 in August. I finished Docetaxyl chemotherapy on 7th Septemb er last year so I've only been on Prostap with prednisolone since then. My onco says he will arrange urgent bone scan and full body
konichiwa12
in
Advanced Prostate Cancer
1 year ago
Xtandi is failing
Details are in my profile. Overall I’ve had good but not remarkably long term PCa control from standard of care treatments. In July 2018 when first diagnosed with widespread multiple tumours, I needed to turn things around in a hurry. Zoladex and docetaxel initially delivered a nadir of 0.06. I
Details are in my profile. Overall I’ve had good but not remarkably long term PCa control from standard of care treatments. In July 2018 when first diagnosed with widespread multiple tumours, I needed to turn things around in a hurry. Zoladex and docetaxel initially delivered a nadir of 0.06. I
Bjry
in
Advanced Prostate Cancer
1 year ago
Elahere trials UK?
Does anyone know what the situation is with clinical trials re the new drug elahere in they U.K? I know in the U.S it has been approved by the FDA but not sure what's happening with drug re U K?
Does anyone know what the situation is with clinical trials re the new drug elahere in they U.K? I know in the U.S it has been approved by the FDA but not sure what's happening with drug re U K?
win_56
in
My Ovacome
1 year ago
Any coming back from this?
Here’s a summary of my father’s situation since he was diagnosed last year in May 2022. I used all of his clinical reports to create this, but you can see my previous posts as well. He’s only 60 years old today - 59 at the time of diagnosis. May 2022: Diagnosed with high burden prostate cancer (Gleason
Here’s a summary of my father’s situation since he was diagnosed last year in May 2022. I used all of his clinical reports to create this, but you can see my previous posts as well. He’s only 60 years old today - 59 at the time of diagnosis. May 2022: Diagnosed with high burden prostate cancer (Gleason
Worriedson9
in
Advanced Prostate Cancer
1 year ago
Efficiency between Erleada & Zytiga?
I need to make a decision between Erleada and zytiga for metastatic ( by psma to LN) HS prostate cancer. Which one should I choose based on efficacy. I am sure some of you are familiar with clinical trials. Thanks for your input.
I need to make a decision between Erleada and zytiga for metastatic ( by psma to LN) HS prostate cancer. Which one should I choose based on efficacy. I am sure some of you are familiar with clinical trials. Thanks for your input.
Ahk1
in
Advanced Prostate Cancer
1 year ago
Clinical trials in Canada for my wife with stage 4 Breast cancer with bone metastatic
I am here to find hope and information on any clinical trials in the US or Canada for my wife with stage 4 Breast cancer with bone metastatic, Appreciate the information
I am here to find hope and information on any clinical trials in the US or Canada for my wife with stage 4 Breast cancer with bone metastatic, Appreciate the information
sammytoronto93
in
SHARE Metastatic Breast Cancer
1 year ago
Stage 4 Breast cancer with bone metastatic
I am here to find hope and clinical trials for my wife with stage 4 Breast cancer with bone metastatic
I am here to find hope and clinical trials for my wife with stage 4 Breast cancer with bone metastatic
sammytoronto93
in
My Breast Cancer Community
1 year ago
Not the odd one out any more
A very knowledgeable source informed me about a multi-institutional UK trial using dose adjustment in ovarian cancer. Does it ring any bells to you? [i]"How does adaptive therapy work?[/i] [i]Resistance comes at a cost to cancer cells, and so they cannot grow as well when they are competing with non-resistant
A very knowledgeable source informed me about a multi-institutional UK trial using dose adjustment in ovarian cancer. Does it ring any bells to you? [i]"How does adaptive therapy work?[/i] [i]Resistance comes at a cost to cancer cells, and so they cannot grow as well when they are competing with non-resistant
Justfor_
in
Fight Prostate Cancer
1 year ago
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