Xtandi is failing

[Bjry]

Details are in my profile. Overall I’ve had good but not remarkably long term PCa control from standard of care treatments.

In July 2018 when first diagnosed with widespread multiple tumours, I needed to turn things around in a hurry. Zoladex and docetaxel initially delivered a nadir of 0.06. I had a 2nd scare in April/May 2022 when my PSA rose to 39 and was doubling every 3 months.

I started Xtandi in about May 2022 and got to 0.08 in a few months but PSA is increasing at a rate of around 10 times every 3 months and is now 8.7; that is concerning. A recent Pet scan showed low tumour volume but low PSMA avidity that unfortunately rules out Lutetium as an option. I see my MO in a couple of weeks when I expect to be prescribed Cabazitaxel.

The main good news is so far my PCa symptoms are more irritating than serious. In 2018 my main disease symptom was bladder control and today my main disease symptom is still bladder control. In February 2023 I was also diagnosed with Barrett’s oesophagus, a biopsy showed some precancerous growth that has been surgically removed - I have 1 last day procedure to remove any remainder.

So what can you do other than enjoy life from one blood test to the next and keep exercising to maintain my reduced stamina. Of course I’m always searching for that that elusive clinical trial offering the chance of longer PCa control.

[Hidden]

Best of luck at your MO appointment.

[Tall_Allen]

Several good choices:

prostatecancer.news/2021/02...

prostatecancer.news/2022/10...

[Bjry in reply to Tall_Allen]

Thanks TA. I've added these to my discussion points with my MO. I was initially afraid I was nearing the end of the treatment pipeline .

[Ramp7]

I did Lupron/Zytiga, and LuPSMA177. Now doing a self administered BAT protocol. I'm responding well. QOL greatly improved. I have convinced my local MO to assist as arms length. This is not SOC. I also have two research Doctors following my progress at the top research medical facilities in the Country.

[Bjry in reply to Ramp7]

Thanks Ramp: I"ve got BAT in my points to raise with my MO.

[Ramp7 in reply to Bjry]

One thing to keep in mind. I was strongly discouraged from going forward with the protocol. Denmeade was positive about BAT but never mentioned doing it alone. It wasn't until I got some positive evidence that I was a responder that my local MO acted in supportive manner.

[Fiddler2004]

Definitely check out the links from Tall Allen especially #2 prostatecancer.news/2022/10...

[Sam2346]

unrelated to pca, but with barrett’s a low acid diet is imperative.

[Bjry in reply to Sam2346]

Thanks Sam, the Barretts was an unexpected pain in the butt. Low acid diet is a good tip.

[Sam2346 in reply to Bjry]

i have gerd, so I have a little idea of what you are going through. find a good group to help with foods

[j-o-h-n]

"the chance of longer PCa control".

Don't stop taking chances.........

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 06/14/2023 6:59 PM DST