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Pioglitazone / Metformin
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Colchicine and Inflammation Revisited
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
MateoBeach
in
Advanced Prostate Cancer
1 year ago
Colchicine and Inflammation Reconsidered
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
MateoBeach
in
Fight Prostate Cancer
1 year ago
Think I have broken my brain ?
Weird brain day, started looking into if any Liverpool GP's prescribe T3. Thanks to a link on another post. Then thought hang on lets check B12 levels and if they affect HbA1c, if Metformin affects B12, before I knew what was happening I have spent hours checking everything. Head is spinning,
Weird brain day, started looking into if any Liverpool GP's prescribe T3. Thanks to a link on another post. Then thought hang on lets check B12 levels and if they affect HbA1c, if Metformin affects B12, before I knew what was happening I have spent hours checking everything. Head is spinning,
Polo22
in
Thyroid UK
1 year ago
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Subclinical hypothyroid and PCOS
Asking on behalf of my 20yo daughter. She recently had a battery of blood tests via an endocrinologist, triggered as a result of massive fatigue, hair thinning, dry skin and very rapid weight gain (20kg in a year even when eating fairly healthily). She was diagnosed with PCOS and her TSH is highish
Asking on behalf of my 20yo daughter. She recently had a battery of blood tests via an endocrinologist, triggered as a result of massive fatigue, hair thinning, dry skin and very rapid weight gain (20kg in a year even when eating fairly healthily). She was diagnosed with PCOS and her TSH is highish
Absolutchaos
in
Thyroid UK
1 year ago
A1C decent with CKD 3A/B
went in for my quarterly 3 month appt last week. I requested the labs be drawn prior to the visit, eGFR came back as 38 with an A1C of 6.4 (down from 6.8 3 months ago). eGFR was down from 55 3 months ago. Dr had me retest and eGFR came back as 49. due to my potassium results 5.7 they had to take
went in for my quarterly 3 month appt last week. I requested the labs be drawn prior to the visit, eGFR came back as 38 with an A1C of 6.4 (down from 6.8 3 months ago). eGFR was down from 55 3 months ago. Dr had me retest and eGFR came back as 49. due to my potassium results 5.7 they had to take
Alexie90
in
Kidney Disease
1 year ago
A few questions for the diabetics here that are on insulin.
I'm a t2 diabetic and have been for over 20 years. Mostly I've kept it under control with A1C around 6, give or take a few. This was with metformin. My CKD has progressed to where I had to stop the metformin. My doctor tried a few other meds but they didn't work. A couple of weeks ago I started
I'm a t2 diabetic and have been for over 20 years. Mostly I've kept it under control with A1C around 6, give or take a few. This was with metformin. My CKD has progressed to where I had to stop the metformin. My doctor tried a few other meds but they didn't work. A couple of weeks ago I started
jodaer
in
Kidney Disease
1 year ago
I got my HbAc1 result sad
Posted other day with my other results full thyroid etc , got lipids will post , HbA1c clotted, Received HbA1c results this morning and cried, last Gp test January said it had gone up to 50, todays is 54 was hoping it had lowered, Now we all know poor thyroid treatment /control can cause mayhem and
Posted other day with my other results full thyroid etc , got lipids will post , HbA1c clotted, Received HbA1c results this morning and cried, last Gp test January said it had gone up to 50, todays is 54 was hoping it had lowered, Now we all know poor thyroid treatment /control can cause mayhem and
Polo22
in
Thyroid UK
1 year ago
PCOS Hair Loss
My daughter has been diagnosed with PCOS and takes Spironolactone and Yacdlla (combined pill). She had to stop Metformin as it didn’t agree with her. we have noticed that when she has 7 days of off Yacdlla she sheds more hair. I know that if you permanently stop the pill you get shedding but we didn
My daughter has been diagnosed with PCOS and takes Spironolactone and Yacdlla (combined pill). She had to stop Metformin as it didn’t agree with her. we have noticed that when she has 7 days of off Yacdlla she sheds more hair. I know that if you permanently stop the pill you get shedding but we didn
walfojr
in
PCOS UK (Verity)
1 year ago
article in the times
One word of caution. A course of high-dose supplements given for at least three months will resolve many deficiencies but, unless diets/medication/underlying conditions change the problem is likely to recur. Many people will require lifelong supplements or, at the very least, future testing to check
One word of caution. A course of high-dose supplements given for at least three months will resolve many deficiencies but, unless diets/medication/underlying conditions change the problem is likely to recur. Many people will require lifelong supplements or, at the very least, future testing to check
Hedgehogs15
in
Pernicious Anaemia Society
1 year ago
Stop B12 Treatment & increase Metformin!
Type 2 diabetes vitamin B12 level 452NG serum folate 4.5 UG. I’ve had anaemia for years and all of the symptoms and more for B12 deficiency/PA . Finally given loading doses a year ago, followed by 4 further shots, three months apart next one, due 25 July. Blood sugar always runs around 50 so well
Type 2 diabetes vitamin B12 level 452NG serum folate 4.5 UG. I’ve had anaemia for years and all of the symptoms and more for B12 deficiency/PA . Finally given loading doses a year ago, followed by 4 further shots, three months apart next one, due 25 July. Blood sugar always runs around 50 so well
Nonameme
in
Pernicious Anaemia Society
1 year ago
Recently diagnosed GCA
After a bad day with severe headaches and sight loss I ended up at the Hospital emergency eye clinic. Diagnosed the next day with GSA and very efficiently put on steroids. I have been put on a 10 month programme and feeling a little shocked. I already have a number of ailments, DB2,AF,HF. My blood pressure
After a bad day with severe headaches and sight loss I ended up at the Hospital emergency eye clinic. Diagnosed the next day with GSA and very efficiently put on steroids. I have been put on a 10 month programme and feeling a little shocked. I already have a number of ailments, DB2,AF,HF. My blood pressure
Doublef
in
PMRGCAuk
1 year ago
metformin
ADT has blown up my diabetes pros and cons of using metformin to control blood sugar…
ADT has blown up my diabetes pros and cons of using metformin to control blood sugar…
rogerandme
in
Advanced Prostate Cancer
1 year ago
Ferratin level
Hi. Probably in t he wrong section but all thoughts welcome. My ferratin is in the 'normal' range but low and dropping, even though I have been taking oral iron spray daily, liquid iron supplement given by my doctor, high iron foods in my diet. I get days of complete fatigue, other days I can cope but
Hi. Probably in t he wrong section but all thoughts welcome. My ferratin is in the 'normal' range but low and dropping, even though I have been taking oral iron spray daily, liquid iron supplement given by my doctor, high iron foods in my diet. I get days of complete fatigue, other days I can cope but
fiftyone
in
Thyroid UK
1 year ago
2 rounds of ICSI both low fertilisation and failed
Hi, I am hoping someone will have similar experience and be able to advise. We had our first ICSI in 2020, we were told to do ICSI as my husbands morphology was low. I’ve had a fertility check were they deemed everything was ok with me, tubes fine and good AMH for my age - I am 34 now. We went straight
Hi, I am hoping someone will have similar experience and be able to advise. We had our first ICSI in 2020, we were told to do ICSI as my husbands morphology was low. I’ve had a fertility check were they deemed everything was ok with me, tubes fine and good AMH for my age - I am 34 now. We went straight
SKS_1
in
Fertility Network UK
1 year ago
Late onset type 1 diabetes?
Husband diagnosed with cirrhosis a couple of months ago, fibroscan reading confirmed this but no varices and no ascites. Waiting to hear back further from gastroenterologist on this. In the meantime, the metformin he had been prescribed for T2 diabetes didn't seem to be working, still had all the symptoms
Husband diagnosed with cirrhosis a couple of months ago, fibroscan reading confirmed this but no varices and no ascites. Waiting to hear back further from gastroenterologist on this. In the meantime, the metformin he had been prescribed for T2 diabetes didn't seem to be working, still had all the symptoms
RugbyMama
in
British Liver Trust
1 year ago
what I think about the Metformin is the cause of my NAFLD
several days ago,I post a question abut the drug of NAFLD , some friends replied the questions and give me many advises. But acturally , I never drink , and I hardly eat sweets , fruits , Junk food, and I do much physical exercise, but I still got NAFLD , my doctor tells me , what you do is enough ,maybe
several days ago,I post a question abut the drug of NAFLD , some friends replied the questions and give me many advises. But acturally , I never drink , and I hardly eat sweets , fruits , Junk food, and I do much physical exercise, but I still got NAFLD , my doctor tells me , what you do is enough ,maybe
xiantaner
in
Living with Fatty Liver and NASH
1 year ago
Recurrent Diahorrea
looking for advice I have had recurring bouts of diahorrea on a regular pattern. Every 3 weeks for 3 to 4 days for a number of years I am on a large amount of medication for anxiety and depression and also for diabetes, I have mentioned this to doctors I.e medical and on mental health side and they have
looking for advice I have had recurring bouts of diahorrea on a regular pattern. Every 3 weeks for 3 to 4 days for a number of years I am on a large amount of medication for anxiety and depression and also for diabetes, I have mentioned this to doctors I.e medical and on mental health side and they have
Cbreeze1961
in
Thyroid UK
1 year ago
palpitations?
I’ve probably asked this before but I feel so frightened. Do others get, fluttering , & a feeling heart has stopped then a thud before it restarts. Started 50 mg prednisolone last august now down to 9. Also have to take leothyroxine & metformin, and atorvastatin. Have had ECG which was ok & done blood
I’ve probably asked this before but I feel so frightened. Do others get, fluttering , & a feeling heart has stopped then a thud before it restarts. Started 50 mg prednisolone last august now down to 9. Also have to take leothyroxine & metformin, and atorvastatin. Have had ECG which was ok & done blood
CavalierKC3
in
PMRGCAuk
1 year ago
c-myc
Further to the "
Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM Complex
" thread, here's a handful of papers of interest. [1] Metformin & c-myc [2] 5-LOXIN & c-myc [3] Sulforaphane & c-myc [4] Honokiol
Further to the "
Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM Complex
" thread, here's a handful of papers of interest. [1] Metformin & c-myc [2] 5-LOXIN & c-myc [3] Sulforaphane & c-myc [4] Honokiol
pca2004
in
Fight Prostate Cancer
1 year ago
Side effects or reactions to Sitagliptin/Metformin hydrochloride for diabetes 2?
High sugar level for diabetes 2 usually have side effects for change of medication have been on metformin for diabetes 2 for three years no problem there. Anybody had side effects for above mixture, I have a combination of other medical conditions so a bit wary there might be some reactions, eg, osteoporosis
High sugar level for diabetes 2 usually have side effects for change of medication have been on metformin for diabetes 2 for three years no problem there. Anybody had side effects for above mixture, I have a combination of other medical conditions so a bit wary there might be some reactions, eg, osteoporosis
Adlon57
in
Healthy Evidence
1 year ago
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