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Neutropenia
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Is this an autoimmune flare up....or some sort of low Ferritin hinterland?
I always have a borderline/low white cell count and have previously been monitored for
Neutropenia
but never really got to the bottom of the cause. I think this could be autoimmune?? On this occasion lower than usual.
I always have a borderline/low white cell count and have previously been monitored for
Neutropenia
but never really got to the bottom of the cause. I think this could be autoimmune?? On this occasion lower than usual.
MacG
in
Thyroid UK
3 years ago
Zanubrutinib looks promising on all fronts in first interim analysis of ALPINE Trial - Ibrutinib v Zanubrutinib in R/R CLL - report from EHA
Rate of
neutropenia
was higher with zanubrutinib (28.4% vs 21.7%), while grade ≥3 infections were lower with zanubrutinib (12.7% vs 17.9%).
Rate of
neutropenia
was higher with zanubrutinib (28.4% vs 21.7%), while grade ≥3 infections were lower with zanubrutinib (12.7% vs 17.9%).
Jm954
Administrator
in
CLL Support
3 years ago
Anaemia and neutropenia with Peg?
Does anyone have any experience of having severe anaemia, and / or
neutropenia
, while taking Peg? I’m currently on 90mcg Pwg weekly for post-ET MF, JAK2+. I’m 41yo and eat a pescatarian diet including all the leafy greens.
Does anyone have any experience of having severe anaemia, and / or
neutropenia
, while taking Peg? I’m currently on 90mcg Pwg weekly for post-ET MF, JAK2+. I’m 41yo and eat a pescatarian diet including all the leafy greens.
LucyGeering
in
MPN Voice
3 years ago
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Long-Term Data Showcase the Clinical Utility of Fixed-Duration Venetoclax/Obinutuzumab in Treatment-Naïve CLL
After treatment, no toxicity was observed, so we don’t see any long-term hematologic toxicities or late-onset
neutropenia
. Those are [toxicities] that we might have seen in the era of more intensive chemoimmunotherapies.
After treatment, no toxicity was observed, so we don’t see any long-term hematologic toxicities or late-onset
neutropenia
. Those are [toxicities] that we might have seen in the era of more intensive chemoimmunotherapies.
lankisterguy
Volunteer
in
CLL Support
3 years ago
New therapy for Small Cell Lung Cancer patients to lower chance of getting neutropenia: FDA Approval of COSELA (trilaciclib)
The FDA based their approval off of three different clinical trials which showed that patients receiving Cosela along with their chemotherapy had a lower chance of getting
neutropenia
(low white blood cell count) and those that did experience
neutropenia
had it for a shorter period of time.
The FDA based their approval off of three different clinical trials which showed that patients receiving Cosela along with their chemotherapy had a lower chance of getting
neutropenia
(low white blood cell count) and those that did experience
neutropenia
had it for a shorter period of time.
Miranda_GO2
Partner
in
Lung Cancer Support
3 years ago
Phase 2 study of MRD driven time limited therapy with Zanubrutinib, Obintuzumab and Venetoclax (BOV) in untreated patients.
The most common treatment emergent AEs were
neutropenia
(49%), infusion related reaction (41%), bruising (41%), diarrhea (39%) and thrombocytopenia (36%). Grade ≥3 AEs occurring in ≥5% pts were
neutropenia
(15%), thrombocytopenia (5%) and pneumonia (5%).
The most common treatment emergent AEs were
neutropenia
(49%), infusion related reaction (41%), bruising (41%), diarrhea (39%) and thrombocytopenia (36%). Grade ≥3 AEs occurring in ≥5% pts were
neutropenia
(15%), thrombocytopenia (5%) and pneumonia (5%).
Jm954
Administrator
in
CLL Support
3 years ago
Cabazitaxel vs Abiraterone or Enzalutamide in Poor-Prognosis Metastatic Castration-Resistant Prostate Cancer
The most common first-line treatment-related grade ≥3 adverse events were
neutropenia
(cabazitaxel 32% vs ARPI 0%), diarrhea (9% vs 0%), infection (9% vs 0%) and fatigue (7% vs 5%).
The most common first-line treatment-related grade ≥3 adverse events were
neutropenia
(cabazitaxel 32% vs ARPI 0%), diarrhea (9% vs 0%), infection (9% vs 0%) and fatigue (7% vs 5%).
Balsam01
in
Advanced Prostate Cancer
3 years ago
Newbie question on prednisolone short course
I have intermittent
neutropenia
and this too is a concern especially as I want to have the Covid vaccine asap. Is it likely that I will be able to improve enough to come off prenisolone after 4 weeks ?
I have intermittent
neutropenia
and this too is a concern especially as I want to have the Covid vaccine asap. Is it likely that I will be able to improve enough to come off prenisolone after 4 weeks ?
Humphreydonk
in
PMRGCAuk
4 years ago
Quick Question to anyone previously shielding, over 70 and in Scotland
My Dad has
neutropenia
and may need a bone marrow transplant, my aunt has just finished chemo for Non Hodgkins and neither has received an invite but at least a dozen friends all in their 70s with no health conditions have all received letters and are booked in.
My Dad has
neutropenia
and may need a bone marrow transplant, my aunt has just finished chemo for Non Hodgkins and neither has received an invite but at least a dozen friends all in their 70s with no health conditions have all received letters and are booked in.
Froggie70
in
LUPUS UK
4 years ago
Switching from Ibrutinib because of neutropenia
I am curious what medication you have been switched to because Ibrutinib was causing
neutropenia
? Did the new medication worked better ?
I am curious what medication you have been switched to because Ibrutinib was causing
neutropenia
? Did the new medication worked better ?
MikeOr
in
CLL Support
4 years ago
Strange case of CLL remission
He did cycle 1 with no issues, cycle 2 with no issues except a severe
neutropenia
where all white cells dropped to 0. The doctor advised us to stop. A month later, all his blood levels restored to levels not seen even during the first treatment.
He did cycle 1 with no issues, cycle 2 with no issues except a severe
neutropenia
where all white cells dropped to 0. The doctor advised us to stop. A month later, all his blood levels restored to levels not seen even during the first treatment.
mkawass
in
CLL Support
4 years ago
Reduced dose Acalabrutinib
Acalabrutinib keeps my CLL in check but gives me
neutropenia
. One strategy would be to cut the usual dose in half to 100 mg/day. Does anyone have experience with this dose? Is it possible that a dose that low could be effective?
Acalabrutinib keeps my CLL in check but gives me
neutropenia
. One strategy would be to cut the usual dose in half to 100 mg/day. Does anyone have experience with this dose? Is it possible that a dose that low could be effective?
john-doe
in
CLL Support
4 years ago
Autoimmune Neutropenia
Please may I ask if anyone has had experience of autoimmune
neutropenia
as I have developed this secondary to my Behcets. Basically I have developed an antibody which is destroying my own neutrophils.
Please may I ask if anyone has had experience of autoimmune
neutropenia
as I have developed this secondary to my Behcets. Basically I have developed an antibody which is destroying my own neutrophils.
NikD
in
Behçet's UK
4 years ago
Neutropenia and Imbruvica
What happens when you are getting neutropenic while taking Imbruvica ? Is your dose is reduced, or Imbruvica is stopped until numbers improve, or something else ?
What happens when you are getting neutropenic while taking Imbruvica ? Is your dose is reduced, or Imbruvica is stopped until numbers improve, or something else ?
MikeOr
in
CLL Support
4 years ago
Looking for a fifth line of CLL treatment
Most all treatments have given me
neutropenia
. My second opinion doctor said, before I started acalabrutinib, that I was running out of effective treatments (I try not to replay his words in my head) and mentioned car-t. I asked him how car-t was going.
Most all treatments have given me
neutropenia
. My second opinion doctor said, before I started acalabrutinib, that I was running out of effective treatments (I try not to replay his words in my head) and mentioned car-t. I asked him how car-t was going.
john-doe
in
CLL Support
4 years ago
BRCA, ATM, CHEK news: ASCO GU 2021: Talazoparib Demonstrates Durable Antitumor Activity in Metastatic Castration-Resistant Prostate Cancer
The most common grade 3/4 treatment-emergent adverse events were anemia (30.7%), thrombocytopenia (8.7%), and
neutropenia
(7.9%).
The most common grade 3/4 treatment-emergent adverse events were anemia (30.7%), thrombocytopenia (8.7%), and
neutropenia
(7.9%).
Balsam01
in
Advanced Prostate Cancer
3 years ago
Biopsy results
Hi, my boyfriend has CLL and is struggling with his hemoglobin and
neutropenia
. His numbers are not getting better. Doctors had to give him multiple blood transfusions and neupogen shot. Even with those, the numbers remain low. He is under Venetoclax treatment.
Hi, my boyfriend has CLL and is struggling with his hemoglobin and
neutropenia
. His numbers are not getting better. Doctors had to give him multiple blood transfusions and neupogen shot. Even with those, the numbers remain low. He is under Venetoclax treatment.
Gile
in
CLL Support
4 years ago
Azothiaprine and recurrent neutropenia MCTD
Anyone else experienced repeated
neutropenia
? Does it mean I will have to stop this drug? Thanks
Anyone else experienced repeated
neutropenia
? Does it mean I will have to stop this drug? Thanks
katiehopeful81
in
LUPUS UK
4 years ago
My "N of 1" trial with Ibrutinib + Idelalisib + Venetoclax that lead to remission of Richter's in three weeks.
Not after 10 days of
Neutropenia
, like it did after the last round I had of R-EPOCH at 140%. It is clear to me that the general and long term side-effects are much lower than the extremely heavy course of chemo I took with R-EPOCH.
Not after 10 days of
Neutropenia
, like it did after the last round I had of R-EPOCH at 140%. It is clear to me that the general and long term side-effects are much lower than the extremely heavy course of chemo I took with R-EPOCH.
UniversallyPersonal
in
CLL Support
4 years ago
Advice required - New to thyroid problems
I was also found to have low complement C3 and C 4, plus mild
neutropenia
, low iron and low ferritin . I have found that supplementation only resolves the iron deficiency for a short period before it returns.
I was also found to have low complement C3 and C 4, plus mild
neutropenia
, low iron and low ferritin . I have found that supplementation only resolves the iron deficiency for a short period before it returns.
Ophelia1
in
Thyroid UK
4 years ago
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