Experiences with

Malignant melanoma

My CLL was diagnosed when getting a mole removed which turns out to be a malignant melanoma. Am going in for some more surgery on my mole shortly and they will run tests on my lymph nodes at the same time. It appears that we are at greater risk of melanoma with CLL.

LIVER, CORE NEEDLE BIOPSY: METASTATIC MALIGNANT MELANOMA. SEE COMMENT. -BRAF NEGATIVE COMMENT: Immunohistochemical staining shows the tumor cells are positive for Melan-A and negative for NKX3.1 and pancytokeratin. The findings support the diagnosis of metastatic melanoma.

Hi Everyone Just a quick follow up to my recent removal of a malignant Melanoma.

May I ask the help and advice of our awesome Forum. This is NOT for me, but for a friend who has just had a facial melanoma (?2a) removed and needs a wider excision. I've looked for HU melanoma communities and surprised to find none with very many members. Our friend needs advice and a 2nd opinion

We did a biopsy and it turned out to be malignant melanoma. Surgery was very successful and I was able to keep. It's definitely affected, but it destroyed my chance of keeping Buy m S.A. Check. Of course, as we all know, one of the many verse factors with many of the current MS.

I am under dermatology as I have recently been treated for malignant melanoma, but they said they didn't know what the rash was but it is nothing to worry about.

[/i] [i]Hydroxychloroquine (HCQ), an autophagy inhibitor that acts by inhibiting lysosomes, has shown efficacy in various cancers, including metastatic pancreatic cancer [16], non-small cell lung cancer [17], refractory multiple myeloma [18], and malignant melanoma [19].

Skin cancers - the most significant class of SPM for CLLers - are very amenable to early diagnosis and treatment, malignant melanoma being the most feared.

When examining the results of phase I and II clinical trials, in which 31 patients with malignant melanoma received TIL therapy, researchers found those who successfully cleared their cancer still showed strong T-cell responses over a year later.

I had a malignant melanoma & a big surgery in October but that didn't seem to poke the PMR beast either. Then a couple of weeks ago it came back with a vengeance- all the old pain, and ESR/CRP back up to where they were right at the start. Has this happened to anyone else?

I am being treated for Necrotising Autoimmune Myositis with Methotrexate and have recently been diagnosed with malignant melanoma. There is some suggestion that I should stop the Methotrexate to allow me to have the treatment for Melanoma which stimulates the immune system.

In the last month I have also had the pleasure of discovering that a small dark spot on the outer edge of my foot - which I have had for ages - and thought only a harmless wee mole - as it was dismissed as not significant by many medical eyes over the years - is actually a melanoma.

Then later in the day my dermatologist calls and the biopsy from last week shows a MALIGNANT MELANOMA- HISTOLOGIC SUBTYPE: MALIGNANT BLUE; SPINDLED.

As with all skin cancers, melanoma can often be seen on the skin, making it easier to detect in its early stages. But, if left undetected, melanoma can spread to distant sites or organs.

I'm caught between a rock & a hard place as I have also been diagnosed with a scary malignant melanoma, and the immunotherapy treatment (which I have not yet been prescribed) is inhibited by steroids.

I was diagnosed with PV in January 21 when I was being treated for a malignant melanoma and the surgeon wanted to do a lymph node biopsy. my red blood cell count at that time was around 0.8. The cancer was removed and I have had a large number of venesections since then.

Does anyone have experience of this with malignant melanoma

I've just been diagnosed with a malignant melanoma. The dermatology nurse said taking steroids for a long time can make this more likely because of the reduced immune response.

Prior to this I was on Azathoprine but had to stop taking it due to been diagnosed with a malignant melanoma which had spread to my lymph nodes in 2007. I’ve had one major flare up in 2013 which was treated with prednisone IV, oral and enemas .

Additional nominally significant associations with malignant melanoma, multiple myeloma, oral cancer, and esophageal squamous cell carcinoma did not survive correction for multiple testing.