3rd update to PSMA PET/liquid blood biopsy at uPSA 0.033 - cancer confirmed

[NanoMRI]

Another reason for annual imaging and liquid blood biopsy testing at my very low stable PSA level:

The statistical outlook does not fit my youthful, fit and otherwise very healthy 67. Just yesterday enjoyed a 9.2 mile rugged trail race with my 'younger' bother and daughter. I hope to draw on my efforts with my metastatic PC and realize long durable remission with this beast as well.

Clinical History/Clinical Impression:

67-year-old male with a history of prostate cancer and melanoma found to have a 2.6 cm liver mass.

DIAGNOSIS:

A. LIVER, CORE NEEDLE BIOPSY:

METASTATIC MALIGNANT MELANOMA. SEE COMMENT.

-BRAF NEGATIVE

COMMENT: Immunohistochemical staining shows the tumor cells

are positive for Melan-A and negative for NKX3.1 and

pancytokeratin. The findings support the diagnosis of metastatic

melanoma.

[103532]

I pray this was found early enough for aggressive treatment. I know you will be all over the treatment options, and please post how you are doing.🙏

[NanoMRI in reply to 103532]

Thank you yes very early, hopefully this offers measurable time. Only one met identified, 'medium size', no physical symptoms. I consider myself most fortunate.

[MoonRocket in reply to NanoMRI]

Melanoma is a skin cancer, no? Did you get your skin checked for the source? I think keytruda may help. Keep us posted.

[NanoMRI in reply to MoonRocket]

yes, skin cancer. I shall add Keytruda to my investigations. Will be heading south in my RV in couple of days from Idaho to family and all the medical availabilities in Houston, TX.

I have had two melanomas surgically removed; one over five years ago and one just a few months ago. Both were 'lower grade' with 'clear margins'. As with PC, good pathology, low PSA, clear imaging does not mean the cancer is not out and about. Additionally challenging is that melanomas can be hidden, unseen; between toes, anus, etc. I get checked at least twice a year with different dermatologists, and I am very diligent, as with PC. I was first to see both of my melanoma's and immediately scheduled appointments.

[MoonRocket in reply to NanoMRI]

After an older sister was treated for Basel cell, I made an appt with the dermatologist to get my skin checked. I think it's time to make another appointment. The only thing worse than fighting one cancer is fighting two cancers. Good luck.

[NanoMRI in reply to MoonRocket]

Appreciate the support. As so many of us have learned with PC, early detection is our best chance for good luck!!

[MoonRocket in reply to NanoMRI]

FYI...j-o-h-n had melanoma in the lung. He was put on Keytruda and I think he's cured now or at least in a long remission. If there's any upside to any of this maybe it'll also have a positive impact on the PCA too.

[NanoMRI in reply to MoonRocket]

many thanks!

[j-o-h-n in reply to MoonRocket]

Yep, you said like it is..... My melanoma metastasis in my lungs was treated with Keytruda and it worked.

Good Luck, Good Health and Good Humor.

j-o-h-n

[NanoMRI in reply to j-o-h-n]

Most Excellent on 85! And a shot of encouragement on Melanoma met - many thanks! Started my reading - how were the Keytruda side-effects?

Had my first and only (so far) Urinary (left) stricture in January 2020 while on holiday in France. Scar tissue suggests caused by radiation - ?

[j-o-h-n in reply to NanoMRI]

1. Absolutely no side effects from the Keytruda.

2. As far as the urinary stricture is concerned, I asked my urologist what he thought might have caused it. His response was that he wasn't sure if it was from the salvage radiation or from having passed (several) kidney stones. To this day I still believe it was from too much sex......and that I will also hit the Lotto....

Good Luck, Good Health and Good Humor.

j-o-h-n

[Channelhomec]

Was this melanoma situ on the top that's what I had ...I was lucky to catch it . The.one time I decided to get my skin checked

[NanoMRI in reply to Channelhomec]

Not situ, metastatic per PSMA PET and MRCP MRI findings and pathology report. My two identified melanomas were on upper back and cheek.

[Channelhomec]

Hope you find a solution, one cancer is bad enough ... good luck ..

[Don717]

Kick it to the curb! Just made an appointment for myself. Got 3 questionable skin lesions I'd like a trained eye to look at. Good luck to ya!