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Restoration of the immune function as a complementary strategy to treat Chronic Lymphocytic Leukemia effectively
This publication is very interesting and describes the latest approaches to the treatment of CLL, relating them to the action of the immune system. There are a number of new insights into the mechanism of CLL such as: "CLL has undergone relevant clinical advances in the past decades, both in the understanding
This publication is very interesting and describes the latest approaches to the treatment of CLL, relating them to the action of the immune system. There are a number of new insights into the mechanism of CLL such as: "CLL has undergone relevant clinical advances in the past decades, both in the understanding
Yalokin
in
CLL Support
2 years ago
A class of targeted protein degraders offers a possible strategy to overcome BTK inhibitor resistance in chronic lymphocytic leukemia
A research article published in the journal [i]Blood [/i]this week reports on a possible way forward for those with CLL who develop
BTK inhibitor resistance that is associated with C481 mutations.
The article is about NRX-0492, a targeted protein degrader. [i]"NRX-0492 induced rapid and sustained
A research article published in the journal [i]Blood [/i]this week reports on a possible way forward for those with CLL who develop
BTK inhibitor resistance that is associated with C481 mutations.
The article is about NRX-0492, a targeted protein degrader. [i]"NRX-0492 induced rapid and sustained
CLLerinOz
Administrator
in
CLL Support
2 years ago
Sample from ASH 2022, CALR antibody
Progress on the immune therapy we've discussed: "In a mouse model of essential thrombocythemia, INCA033989 selectively decreased levels of mutant CALR-positive platelets, re-established normal megakaryopoiesis, and selectively targeted mutant CALR disease-initiating clones. " https://www.cancertherapyadvisor.com
Progress on the immune therapy we've discussed: "In a mouse model of essential thrombocythemia, INCA033989 selectively decreased levels of mutant CALR-positive platelets, re-established normal megakaryopoiesis, and selectively targeted mutant CALR disease-initiating clones. " https://www.cancertherapyadvisor.com
EPguy
in
MPN Voice
2 years ago
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Richter’s Transformation - Detection of early seeding of Richter transformation in chronic lymphocytic leukemia
Very interesting article on TR with Dr. Elias Campo among other doctors. Article published by the journal Nature. Posted on August 11. Read it because it gives a lot of information and within this study we are myself and two other people from this group among other cases that we offered ourselves for
Very interesting article on TR with Dr. Elias Campo among other doctors. Article published by the journal Nature. Posted on August 11. Read it because it gives a lot of information and within this study we are myself and two other people from this group among other cases that we offered ourselves for
Priss69
in
CLL Support
2 years ago
Interesting article in the news ,NHL diagnosis for military personnel
[i] i thought this was a rather interesting article about the officers working at the Montana nuclear site getting Leukemia . here is a portion of the article ...maybe some of us are more susceptible to the radiation from our xrays and ct scans then others ... ----- "The US military is looking
[i] i thought this was a rather interesting article about the officers working at the Montana nuclear site getting Leukemia . here is a portion of the article ...maybe some of us are more susceptible to the radiation from our xrays and ct scans then others ... ----- "The US military is looking
craterlake
in
CLL Support
1 year ago
Places available today 3.30pm GMT - WEBINAR - UK employment rights
Hi everyone this afternoon Leukaemia Care and ACAS are providing an information webinar to inform blood cancer patients of employment rights. You are welcome to join us free here: https://us02web.zoom.us/webinar/register/WN_Jv6gP8ddSJ2Y7Jrs8S5u3Q
Start 3.30pm GMT
If you have been affected
Hi everyone this afternoon Leukaemia Care and ACAS are providing an information webinar to inform blood cancer patients of employment rights. You are welcome to join us free here: https://us02web.zoom.us/webinar/register/WN_Jv6gP8ddSJ2Y7Jrs8S5u3Q
Start 3.30pm GMT
If you have been affected
HAIRBEAR_UK
in
Leukaemia Support
2 years ago
Astonishing' Results: Skip Salvage Chemo,Go Straight to HSCT
»NEW ORLEANS — Investigators confessed to being "astonished" by results of a randomized trial showing that patients with acute myeloid leukemia who have a poor response following induction therapy do just as well going on to immediate allogeneic transplant as they would if they had received an intensive
»NEW ORLEANS — Investigators confessed to being "astonished" by results of a randomized trial showing that patients with acute myeloid leukemia who have a poor response following induction therapy do just as well going on to immediate allogeneic transplant as they would if they had received an intensive
Manouche
in
MPN Voice
2 years ago
Day +99
Hello friends, Well I am almost at 100 days post transplant and feeling surprisingly well under the circumstances. My check ups have been reduced to once a week and my blood counts are slowly improving. Hb currently at 89 and platelets at 46 so my donor cells are working hard and I haven't needed a
Hello friends, Well I am almost at 100 days post transplant and feeling surprisingly well under the circumstances. My check ups have been reduced to once a week and my blood counts are slowly improving. Hb currently at 89 and platelets at 46 so my donor cells are working hard and I haven't needed a
Otterfield
in
MPN Voice
2 years ago
Off patent drug possibility for Covid. Ursodeoxycholic acid (UDCA), an approved liver disease drug, reduces ACE2 levels on lab-grown cells
There seems to be a deal of excitement in certain media areas about research involving UK, European and US researchers on a covid treatment drug. The one in question is an off patent drug ursodeoxycholic acid currently used to treat liver damage so a re-purposing rather than development of a new drug
There seems to be a deal of excitement in certain media areas about research involving UK, European and US researchers on a covid treatment drug. The one in question is an off patent drug ursodeoxycholic acid currently used to treat liver damage so a re-purposing rather than development of a new drug
Eucalyptus22
in
CLL Support
2 years ago
Looking for more wholistic answers to dealing with ITP
Hi, I am newly diagnosed since Aug. 2022 with ITP and have had two crashes with platelet levels in the single digits twice now. Last week they put me on a short dose of dexamethasone which helped and now I am getting Nplate injections weekly for a month. From everything I have read, I cannot find
Hi, I am newly diagnosed since Aug. 2022 with ITP and have had two crashes with platelet levels in the single digits twice now. Last week they put me on a short dose of dexamethasone which helped and now I am getting Nplate injections weekly for a month. From everything I have read, I cannot find
bonandmick
in
ITP Support Association
2 years ago
EXTREME bone pain with Neupogen injections, advise welcome!
Has anyone experienced extreme pain with Neupogen GCSF injections? My husband has received 2 out of 4 injections and is in agonizing bone pain. His specialist recommended a hot bath, Claritin, and Tylenol. I also have a heating pad on his back. Just wondering how long this will last and how he is going
Has anyone experienced extreme pain with Neupogen GCSF injections? My husband has received 2 out of 4 injections and is in agonizing bone pain. His specialist recommended a hot bath, Claritin, and Tylenol. I also have a heating pad on his back. Just wondering how long this will last and how he is going
lisakc1
in
CLL Support
2 years ago
ALC is still going up
Well, today I had another CBC. My ALC continues to go up consistently at each 2 week check and I will be seeing my onco at the beginning of Feb. In addition to the rising alc, test shows a few other little changes that i don't fully understand -- my MCV is now reading high (99.50) and my MCHC is low
Well, today I had another CBC. My ALC continues to go up consistently at each 2 week check and I will be seeing my onco at the beginning of Feb. In addition to the rising alc, test shows a few other little changes that i don't fully understand -- my MCV is now reading high (99.50) and my MCHC is low
Moonmyst
in
CLL Support
2 years ago
Lymphatic Drainage by Vibration Platforms
The attached article reports apoptosis of cancer cells by low frequency vibration (not CLL & experiment was in-vitro) Vibration platforms claim multiple fold increase in lymphatic circulation and drainage. Lymphatic drainage is good for CLL. Can there be a small chance that vibration platforms
The attached article reports apoptosis of cancer cells by low frequency vibration (not CLL & experiment was in-vitro) Vibration platforms claim multiple fold increase in lymphatic circulation and drainage. Lymphatic drainage is good for CLL. Can there be a small chance that vibration platforms
nuji
in
CLL Support
2 years ago
(Originally posted by Hunter) "Recent forum presented by our friends at MPN Advocacy & Education International"
Hunter found this presentation: https://healthunlocked.com/mpnvoice/posts/148836859/boston-mpn-patient-caregiver-program-presented-by-mpn-advocacy-education-international Great find. I went through the videos and have some notes/comments. I figured a top post should be most helpful. --
Dr. Raagit
Hunter found this presentation: https://healthunlocked.com/mpnvoice/posts/148836859/boston-mpn-patient-caregiver-program-presented-by-mpn-advocacy-education-international Great find. I went through the videos and have some notes/comments. I figured a top post should be most helpful. --
Dr. Raagit
EPguy
in
MPN Voice
2 years ago
Exercise is the fountain of youth
I always loved the natural high that exercise brings but I never really knew how totally therapeutic it is. I was always the Captain in Team Sports growing up & just generally active. Things slowed down during college & never got added to my ‘adult’ life of creating a career & family. Anyway, after
I always loved the natural high that exercise brings but I never really knew how totally therapeutic it is. I was always the Captain in Team Sports growing up & just generally active. Things slowed down during college & never got added to my ‘adult’ life of creating a career & family. Anyway, after
CoachVera55
in
CLL Support
2 years ago
Having to start treatment
CLL with no mutations. Numbers are very high and I have no visible symptoms. I'm going to need to start treatment. The two options I am being told are Ibrutinib or Venetoclax. I am a healthy person not overweight I'm on no medication I'm 60 years old are there any thoughts on which medication. And has
CLL with no mutations. Numbers are very high and I have no visible symptoms. I'm going to need to start treatment. The two options I am being told are Ibrutinib or Venetoclax. I am a healthy person not overweight I'm on no medication I'm 60 years old are there any thoughts on which medication. And has
Mog811
in
CLL Support
2 years ago
myelofibrosis
Does anyone on here know if mf should always be treated,main symptom is fatigue, slightly enlarged spleen and slight anaemia ( for 3 years)not sure about the watch and wait approach.
Does anyone on here know if mf should always be treated,main symptom is fatigue, slightly enlarged spleen and slight anaemia ( for 3 years)not sure about the watch and wait approach.
glyndale
in
MPN Voice
2 years ago
Some good Clonoseq results
I just wanted to share that I received some positive news from Clonoseq blood test. This is a blood test for MRD. It did not detect any CLL. So, my doctor has scheduled a bone marrow biopsy to do further testing. If that too comes back negative, I will be able to go off treatment. I started my
I just wanted to share that I received some positive news from Clonoseq blood test. This is a blood test for MRD. It did not detect any CLL. So, my doctor has scheduled a bone marrow biopsy to do further testing. If that too comes back negative, I will be able to go off treatment. I started my
Kvb-texas
in
CLL Support
2 years ago
WBC rising
After 2 years in remission post B+R my white count is starting to go up. In Aug. it was 7.925, Dec 8 was 11.78, and last week was 15.05. I have to go for another CBC next week. I am also noticing periods of feeling a little out of breath with little exertion. I'm scared that this might be heading
After 2 years in remission post B+R my white count is starting to go up. In Aug. it was 7.925, Dec 8 was 11.78, and last week was 15.05. I have to go for another CBC next week. I am also noticing periods of feeling a little out of breath with little exertion. I'm scared that this might be heading
Moonmyst
in
CLL Support
2 years ago
CLL Staging
Hello. My husband, Simon, was diagnosed with CLL several years ago and has been closely monitored. On his last visit to his consultant he was told that he needs to start treatment. Either Rituximab or Venetoclax. My husband is always dismissive of his condition and does not want to discuss with me
Hello. My husband, Simon, was diagnosed with CLL several years ago and has been closely monitored. On his last visit to his consultant he was told that he needs to start treatment. Either Rituximab or Venetoclax. My husband is always dismissive of his condition and does not want to discuss with me
Rocky0181
in
CLL Support
2 years ago
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