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Imbruvica-related issues: Qs + comments
The following are questions and comments I'll be asking my oncologist when I see him tomorrow. I believe at least some of them might be relevant to what some among us are experiencing and research some of us are engaging in. Clearly, none of the comments here are meant to be authoritative nor intended
The following are questions and comments I'll be asking my oncologist when I see him tomorrow. I believe at least some of them might be relevant to what some among us are experiencing and research some of us are engaging in. Clearly, none of the comments here are meant to be authoritative nor intended
Pogee
in
CLL Support
4 years ago
FCR
I’ll avoid FCR at all. Dangerous and tricky. Increase the probability of AL occurrence as well as second neoplasm and Richter transformation in the long run. You have to be "fit patient” to receive FCR, IGHV mutated and without tp53 mutation or 17p deletion. Find a responsible doctor with a robust experience
I’ll avoid FCR at all. Dangerous and tricky. Increase the probability of AL occurrence as well as second neoplasm and Richter transformation in the long run. You have to be "fit patient” to receive FCR, IGHV mutated and without tp53 mutation or 17p deletion. Find a responsible doctor with a robust experience
Rccfrc00
in
CLL Support
4 years ago
flair ..fcr
hi all i have had cll from 2012 i have been on w&w my question is i have signed up for the flair trail Manchester Christie i got phone call this week saying i was randomized for FCR my age is 57yrs i have no tp53 or any other abnormal readings and i dont know what my mutations are etc mutated or unmutated
hi all i have had cll from 2012 i have been on w&w my question is i have signed up for the flair trail Manchester Christie i got phone call this week saying i was randomized for FCR my age is 57yrs i have no tp53 or any other abnormal readings and i dont know what my mutations are etc mutated or unmutated
kel555
in
CLL Support
4 years ago
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Documented remission without drugs
I've just come across an article on a remarkable, well-documented, case of a younger man with CLL who, over time, achieved complete remission without drugs. Here's the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739749/ * I hasten to add that this is but a single case, and I'm not recommending
I've just come across an article on a remarkable, well-documented, case of a younger man with CLL who, over time, achieved complete remission without drugs. Here's the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739749/ * I hasten to add that this is but a single case, and I'm not recommending
Pogee
in
CLL Support
4 years ago
Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? - Not necessarily. The BTK inhibitors are excellent at....
Below is a repost from CLLSLL@groups.io ( permission granted by Dr. Furman) - I believe this hypothesis may be tested in a proposed clinical trial Dr. Furman has mentioned in the past- Len - Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? From: ------ Date: Thu, 23 Jul
Below is a repost from CLLSLL@groups.io ( permission granted by Dr. Furman) - I believe this hypothesis may be tested in a proposed clinical trial Dr. Furman has mentioned in the past- Len - Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? From: ------ Date: Thu, 23 Jul
lankisterguy
Volunteer
in
CLL Support
4 years ago
Resistance-Associated Mutations in CLL Patients Treated With Novel Agents
This is slightly complex but good overview of the acquired resistance mechanisms to novel agents. In 80% of patients with ibrutinib failure, acquired mutations in BTK and PLCG2 genes were detected. No common resistance-associated mutations or deregulated signaling pathways have been reported in idelalisib
This is slightly complex but good overview of the acquired resistance mechanisms to novel agents. In 80% of patients with ibrutinib failure, acquired mutations in BTK and PLCG2 genes were detected. No common resistance-associated mutations or deregulated signaling pathways have been reported in idelalisib
Jm954
Administrator
in
CLL Support
4 years ago
Richter transformation after quitting ibrutinib: a diagnostic error
Hi all. The topic of the connection between Ibrutinib and the Richter transformation is getting very interesting. In the group that I have on Facebook every day people are entering that once Ibrutinib left a few days for an operation or biopsy for another movement, Richter was diagnosed. Then the Pet
Hi all. The topic of the connection between Ibrutinib and the Richter transformation is getting very interesting. In the group that I have on Facebook every day people are entering that once Ibrutinib left a few days for an operation or biopsy for another movement, Richter was diagnosed. Then the Pet
Priss69
in
CLL Support
4 years ago
CSIRO uses lab-grown ‘lungs’ to fight respiratory viruses
Researchers at Australia's national science agency, CSIRO, found that lab-grown cells from the upper layer of the airway to the lungs – the human bronchial epithelium – reliably mimic a live person's airway's response to viruses. CSIRO Research Scientist Dr Elizabeth Pharo is the lead author on the findings
Researchers at Australia's national science agency, CSIRO, found that lab-grown cells from the upper layer of the airway to the lungs – the human bronchial epithelium – reliably mimic a live person's airway's response to viruses. CSIRO Research Scientist Dr Elizabeth Pharo is the lead author on the findings
2greys
in
Lung Conditions Community Forum
4 years ago
FDA approves ibrutinib plus rituximab for chronic lymphocytic leukemia
https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-ibrutinib-plus-rituximab-chronic-
lymphocytic
-
leukemia
?fbclid=IwAR02tCtziW0mkgktq3Pg_o5drjFaH1xYBYArkn4ZlVicIo7pVzStrrFKWs4
https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-ibrutinib-plus-rituximab-chronic-
lymphocytic
-
leukemia
?fbclid=IwAR02tCtziW0mkgktq3Pg_o5drjFaH1xYBYArkn4ZlVicIo7pVzStrrFKWs4
chickenandwaffles
in
CLL Support
4 years ago
Illuminating novel biological aspects and potential new therapeutic approaches for chronic myeloproliferative malignancies
Abstract This review reflects the presentations and discussion at the 14th post‐ASH International Workshop on Chronic Myeloproliferative Malignancies, which took place on the 10th‐11th December 2019, immediately after the 61st American Society of Hematology (ASH) Annual Meeting in Orlando, Florida. Rather
Abstract This review reflects the presentations and discussion at the 14th post‐ASH International Workshop on Chronic Myeloproliferative Malignancies, which took place on the 10th‐11th December 2019, immediately after the 61st American Society of Hematology (ASH) Annual Meeting in Orlando, Florida. Rather
Manouche
in
MPN Voice
4 years ago
CLL Society Dr. Koffman's ASCO 2020 "Top 12" Picks #s 12, 11, 10
Dr. Koffman’s ASCO 2020 “Top 12” Picks The 2020 Annual Meeting of the American Society of Clinical Oncology (ASCO) was held virtually in May. While ASCO remains more focused on the latest research in solid tumors, there were several worthwhile abstracts related to CLL. Dr. Koffman takes us through his
Dr. Koffman’s ASCO 2020 “Top 12” Picks The 2020 Annual Meeting of the American Society of Clinical Oncology (ASCO) was held virtually in May. While ASCO remains more focused on the latest research in solid tumors, there were several worthwhile abstracts related to CLL. Dr. Koffman takes us through his
bkoffman
CLL CURE Hero
in
CLL Support
4 years ago
W&W CLL Patient in Need of Advice
CLL patient for 4 years with 22 wbc and on w&w I visited my Oncologist last Tuesday and explained that I am experiencing a continuous high level of body pain hoping that I would receive something other than take some Advil. Not sure if they understand that this is a daily pain and I cannot be expected
CLL patient for 4 years with 22 wbc and on w&w I visited my Oncologist last Tuesday and explained that I am experiencing a continuous high level of body pain hoping that I would receive something other than take some Advil. Not sure if they understand that this is a daily pain and I cannot be expected
Hidden
in
CLL Support
4 years ago
Bendamustine with rituximab
my husband was diagnosed with CLL and will be starting on the above agents over the next 6 months. Anyone has experienced the same treatment before?
my husband was diagnosed with CLL and will be starting on the above agents over the next 6 months. Anyone has experienced the same treatment before?
gohmei
in
CLL Support
4 years ago
CLL Society & CancerCare Update on Chronic Lymphocytic Leukemia (CLL)
CLL Society & CancerCare Update on Chronic
Lymphocytic
Leukemia
(CLL) Thursday, April 9th at 4:00p.m. ET/ 1:00p.m. PT Drs. Adam Kittai, Deborah Stephens, Lindsey Roeker + Patricia Koffman, Ex. Dir.
CLL Society & CancerCare Update on Chronic
Lymphocytic
Leukemia
(CLL) Thursday, April 9th at 4:00p.m. ET/ 1:00p.m. PT Drs. Adam Kittai, Deborah Stephens, Lindsey Roeker + Patricia Koffman, Ex. Dir.
bkoffman
CLL CURE Hero
in
CLL Support
4 years ago
A JEDI WARRIOR's TALE
Post by MPN-MATE Admin » Sun Jun 21, 2020 10:52 am Morning everyone... :-) I am feeling quite chuffed and privileged today as we have just had someone that has always inspired my own MPN journey, (join us here at MATES), by penning his arduous account of what is was like to go through the whole process
Post by MPN-MATE Admin » Sun Jun 21, 2020 10:52 am Morning everyone... :-) I am feeling quite chuffed and privileged today as we have just had someone that has always inspired my own MPN journey, (join us here at MATES), by penning his arduous account of what is was like to go through the whole process
socrates_8
in
MPN Voice
4 years ago
Normal CBC abnormal flow test
I had two months of abnormal CB results, and the flow study also abnormal. I was diagnosed with possible CLL. I then had a CBC done yesterday after three months and everything in the CBC is normal. Do I now not have a Blood cancer? Is it a miracle or does this happen sometimes? I have had no treatment
I had two months of abnormal CB results, and the flow study also abnormal. I was diagnosed with possible CLL. I then had a CBC done yesterday after three months and everything in the CBC is normal. Do I now not have a Blood cancer? Is it a miracle or does this happen sometimes? I have had no treatment
gustave
in
CLL Support
4 years ago
Venetoclax plus obinutuzumab - the first chemotherapy-free, fixed-duration first line CLL treatment approved by Health Canada
[i] * VENCLEXTA® (venetoclax) plus obinutuzumab is the first chemotherapy-free, fixed-duration combination regimen approved by Health Canada for patients with previously untreated chronic
lymphocytic
leukemia
(CLL).
[i] * VENCLEXTA® (venetoclax) plus obinutuzumab is the first chemotherapy-free, fixed-duration combination regimen approved by Health Canada for patients with previously untreated chronic
lymphocytic
leukemia
(CLL).
AussieNeil
Partner
in
CLL Support
4 years ago
Fatigue with CLL
Hello I was diagnosed cll on January 2019 cll stage 0, my wbc was 30, on June 2020 is 49 no symptoms except my gamma globulin is slightly lower than normal. I am still on w/w, but i feel all time tired and I cannot work on morning, I start only at 14h. Also I am anxious, I think all time about my cll
Hello I was diagnosed cll on January 2019 cll stage 0, my wbc was 30, on June 2020 is 49 no symptoms except my gamma globulin is slightly lower than normal. I am still on w/w, but i feel all time tired and I cannot work on morning, I start only at 14h. Also I am anxious, I think all time about my cll
Hicham
in
CLL Support
4 years ago
Webinar - CLL treatment a changing landscape
When: Jun 29, 2020 11:00AM We invite you to Join us for an upcoming webinar on chronic lymphocytic leukaemia (CLL) treatment. Register here https://www.leukaemiacare.org.uk/support-and-information/support-for-you/online-webinars/cll-treatment-a-changing-landscape/ We will joined by: Professor Anna Schuh
When: Jun 29, 2020 11:00AM We invite you to Join us for an upcoming webinar on chronic lymphocytic leukaemia (CLL) treatment. Register here https://www.leukaemiacare.org.uk/support-and-information/support-for-you/online-webinars/cll-treatment-a-changing-landscape/ We will joined by: Professor Anna Schuh
HAIRBEAR_UK
in
Leukaemia Support
4 years ago
Report from CLL Webinar: Prof Hillmen, 10th June 2020
I attended a webinar hosted by the CLL Support Association and Leukaemia Care. Thanks to everyone responsible for organising the event, I found it most informative. The guest keynote speaker was Prof. Peter Hillmen, Consultant in Clinical Haematology at Leeds Teaching Hospitals NHS Trust and Honorary
I attended a webinar hosted by the CLL Support Association and Leukaemia Care. Thanks to everyone responsible for organising the event, I found it most informative. The guest keynote speaker was Prof. Peter Hillmen, Consultant in Clinical Haematology at Leeds Teaching Hospitals NHS Trust and Honorary
Davdow
in
CLL Support
4 years ago
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