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Malecare newsletter reports Finish study glucocorticoids (e.g. prednisone, prednisolone, dexamethasone) can lead to castrate resistance
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
Graham49
in
Advanced Prostate Cancer
6 months ago
how to reduce testosterone after orchiectomy
NOTE : An orchiectomy is a surgical procedure to remove one or both testicles. Posting here to learn from others. Questions is How to reduce testosterone after Orchiectomy ?
NOTE : An orchiectomy is a surgical procedure to remove one or both testicles. Posting here to learn from others. Questions is How to reduce testosterone after Orchiectomy ?
God_Loves_Me
in
Advanced Prostate Cancer
6 months ago
PA and the Dentist
I have found someone who understand PA ! My new dentist. I have had PA since 2015 and this is only the second person. The other was a physiotherapist whose sister had it. I broke a tooth and had to see a different partner in the practice and told her I had PA and she said " oh dear, that is difficult
I have found someone who understand PA ! My new dentist. I have had PA since 2015 and this is only the second person. The other was a physiotherapist whose sister had it. I broke a tooth and had to see a different partner in the practice and told her I had PA and she said " oh dear, that is difficult
purpleabc
in
Pernicious Anaemia Society
14 days ago
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Thyroid Medication query
I have always taken TEVA Levothyroxine for years - a couple of months ago I noticed the packaging had changed but I was told they were the same. After taking the new one for a couple of month I became very ill, I had to stop taking them. After contacting my doctors I was told there are no other options
I have always taken TEVA Levothyroxine for years - a couple of months ago I noticed the packaging had changed but I was told they were the same. After taking the new one for a couple of month I became very ill, I had to stop taking them. After contacting my doctors I was told there are no other options
emilysnannie
in
Thyroid UK
14 days ago
Buscopan ibs relief
Has anyone tried this for their ibs. I don't usually take medication but as an ibs-d sufferer normally, suddenly I have started with ibs-c and ibs-d alternately. Sometimes my gut feels as if it's rushing everything through, and other times it seems to come to a full stop. In addition, I have started
Has anyone tried this for their ibs. I don't usually take medication but as an ibs-d sufferer normally, suddenly I have started with ibs-c and ibs-d alternately. Sometimes my gut feels as if it's rushing everything through, and other times it seems to come to a full stop. In addition, I have started
iloveglee
in
IBS Network
15 days ago
Support in your local community.
The day all treatment ended and I was released to begin life without the benefit of seeing my radiation oncologist or the infusion nurse on a weekly basis was a scary day. The idea that it would be three months before I saw anyone again left me overwhelmed. Finding web boards like these and in person
The day all treatment ended and I was released to begin life without the benefit of seeing my radiation oncologist or the infusion nurse on a weekly basis was a scary day. The idea that it would be three months before I saw anyone again left me overwhelmed. Finding web boards like these and in person
Denzie
Volunteer
in
Lung Cancer Support
6 months ago
Endoscopy & diverticulitis
Dr wants to do endoscopy in 8 weeks time to see if infection has gone. Won't blood tests, and lack of pain tell him that? What are the benefits of an endoscopy?
Dr wants to do endoscopy in 8 weeks time to see if infection has gone. Won't blood tests, and lack of pain tell him that? What are the benefits of an endoscopy?
Nobby21
in
IBS Network
15 days ago
FYI ... Early-Onset Colorectal Cancer
Early-onset colorectal cancer (EOCRC) is colon cancer or rectal cancer diagnosed before the age of 50. It is also known as early age onset CRC and young-onset colorectal cancer. Early-onset CRC accounts for about 10% of colon cancers and 15-20% of rectal cancers. For more info .... https://www.globalcca.org
Early-onset colorectal cancer (EOCRC) is colon cancer or rectal cancer diagnosed before the age of 50. It is also known as early age onset CRC and young-onset colorectal cancer. Early-onset CRC accounts for about 10% of colon cancers and 15-20% of rectal cancers. For more info .... https://www.globalcca.org
GCCA-Survivor
Administrator
in
Colon Cancer Connected
15 days ago
B12 blood test result explained?
hi all. I have been told my GP that my B12 levels are low and that I need to take a supplement lifelong. My results a show Plasma vitamin B12 level - 49 pmol/l. Does anyone know is this is very low? Or just a little bit?
hi all. I have been told my GP that my B12 levels are low and that I need to take a supplement lifelong. My results a show Plasma vitamin B12 level - 49 pmol/l. Does anyone know is this is very low? Or just a little bit?
HP12
in
Pernicious Anaemia Society
15 days ago
IBS stomach issues
For years we have experienced stomach issues and pain while eating pretty much anything. We have tried the fodmap diet, and medications. We have now done a colonoscopy and are on prescription medication. We are very concerned that these meds are not helping after 3 months of taking them. Has anyone else
For years we have experienced stomach issues and pain while eating pretty much anything. We have tried the fodmap diet, and medications. We have now done a colonoscopy and are on prescription medication. We are very concerned that these meds are not helping after 3 months of taking them. Has anyone else
Greenbulldogs
in
Pernicious Anaemia Society
15 days ago
Just saying hello as a new member
I was just recently diagnosed with MBC in January 2024 but no stranger to breast cancer as I had already had a tangle with (what I was assured was a very low risk) breast cancer back in 2014 and underwent surgery for a lumpectomy and a subsequent regimen of 6 1/2 weeks of m-f radiation. I thought all
I was just recently diagnosed with MBC in January 2024 but no stranger to breast cancer as I had already had a tangle with (what I was assured was a very low risk) breast cancer back in 2014 and underwent surgery for a lumpectomy and a subsequent regimen of 6 1/2 weeks of m-f radiation. I thought all
CatLoverinthe206
in
SHARE Metastatic Breast Cancer
6 months ago
folate deficiency and extensive bowel surgeries. Is there any causal link?
Dose any inject their own folate and is their anyone out there with Short Bowl Syndrome with vitamin and mineral deficiencies?
Dose any inject their own folate and is their anyone out there with Short Bowl Syndrome with vitamin and mineral deficiencies?
Beck71
in
Pernicious Anaemia Society
15 days ago
6ft 2in & 25mcg levo
Hi allJust a bit of a rant. My sister told me a while ago that my nephew had been diagnosed with a thyroid problem. Spoke to him today. He is a big guy. He is on 25mcg levo as 'his levels are only a little low and he just needs a top-up' according to his gp. They have however put him on statins as his
Hi allJust a bit of a rant. My sister told me a while ago that my nephew had been diagnosed with a thyroid problem. Spoke to him today. He is a big guy. He is on 25mcg levo as 'his levels are only a little low and he just needs a top-up' according to his gp. They have however put him on statins as his
tuchwood
in
Thyroid UK
16 days ago
Hemin may be useful as prodrug for prostate cancer. It strongly induced caspase-3 activation, PARP degradation, and apoptosis in PC-3 cells
Only an invitro study but Hemin is already used to treat acute porphyria. “Given that hemin has been safely administered as a daily infusion at doses ranging from 1 to 4 mg/kg for 3 to 14 days in the treatment of porphyria [32], it holds significant promise for drug development.” Anticancer Effect of
Only an invitro study but Hemin is already used to treat acute porphyria. “Given that hemin has been safely administered as a daily infusion at doses ranging from 1 to 4 mg/kg for 3 to 14 days in the treatment of porphyria [32], it holds significant promise for drug development.” Anticancer Effect of
Graham49
in
Fight Prostate Cancer
16 days ago
help with iron levels please for RLS, please?
Following all the helpful advice on here to raise my iron levels, I have been taking iron since February. My levels then were Serum Ferritin 19 ug/L Transferrin Sat. Index 24% Serum Iron 15.5 umo/l As advised on here, I have been taking 100mg iron bisglycinate every other night, with vit C, on an
Following all the helpful advice on here to raise my iron levels, I have been taking iron since February. My levels then were Serum Ferritin 19 ug/L Transferrin Sat. Index 24% Serum Iron 15.5 umo/l As advised on here, I have been taking 100mg iron bisglycinate every other night, with vit C, on an
Lacey_
in
Restless Legs Syndrome
17 days ago
B12 Deficiency
hi everyone, just wanting peoples thoughts or advice on the following: I had a B12 serum test done which showed my B12 was low at 188 on the 28th of august. This was repeated on September the 2nd and came out at 232 without treatment. My intrinsic factor was also negative. I have loads of B12 symptoms
hi everyone, just wanting peoples thoughts or advice on the following: I had a B12 serum test done which showed my B12 was low at 188 on the 28th of august. This was repeated on September the 2nd and came out at 232 without treatment. My intrinsic factor was also negative. I have loads of B12 symptoms
Hammy2024
in
Pernicious Anaemia Society
17 days ago
End of fixed duration treatment
Completed 2 yr treatment on Rituximab and Venetoclax approximately 4 weeks ago. Consultant says I'm in remission and not to worry there are other treatments I can have. That kind of took any euphoria out of my sails!Still suffering from GI problems constant visits to the loo. Colonoscopy shows some
Completed 2 yr treatment on Rituximab and Venetoclax approximately 4 weeks ago. Consultant says I'm in remission and not to worry there are other treatments I can have. That kind of took any euphoria out of my sails!Still suffering from GI problems constant visits to the loo. Colonoscopy shows some
Fastbike14
in
CLL Support
17 days ago
Picolax bowel prep
Hi hope all is well, I am currently in a mild flare up again due to change in weather temperatures as I seem to get flare-ups every autumn/winter and always fine in the summer is very strange. Anyway I am booked for a sigmoidoscopy in October and will be given Picolax just wondering how others were with
Hi hope all is well, I am currently in a mild flare up again due to change in weather temperatures as I seem to get flare-ups every autumn/winter and always fine in the summer is very strange. Anyway I am booked for a sigmoidoscopy in October and will be given Picolax just wondering how others were with
Sooty712
in
Crohn's and Colitis Support
17 days ago
Bad Diarrhoea & Gas
I’m sorry if this post sounds quite rank, but I just wondered if anyone else is experiencing this. For the last 4 days I have been getting stomach cramps, and my stomach has been doing a lot of churning noises, which lead to really really bad gas and diarrhoea! It’s been 4 days in a row now, at night
I’m sorry if this post sounds quite rank, but I just wondered if anyone else is experiencing this. For the last 4 days I have been getting stomach cramps, and my stomach has been doing a lot of churning noises, which lead to really really bad gas and diarrhoea! It’s been 4 days in a row now, at night
KateD2707
in
Fertility Network UK
17 days ago
Review: The Latest Data Concerning the Etiology and Pathogenesis of Irritable Bowel Syndrome (IBS)
Abstract
Globally, irritable bowel syndrome (IBS) is present in approximately 10% of the population. While this condition does not pose a risk of complications, it has a substantial impact on the patient’s quality of life. Moreover, this disease has a significant financial impact on healthcare
Abstract
Globally, irritable bowel syndrome (IBS) is present in approximately 10% of the population. While this condition does not pose a risk of complications, it has a substantial impact on the patient’s quality of life. Moreover, this disease has a significant financial impact on healthcare
Meleber
in
IBS Network
17 days ago
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