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GnRH agonist
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Advice
Hey, was just wondering if someone could help. I had my diagnostic lap December 2019, where mild endo was found in pouch of Douglas and uterosacral ligaments. The doctor said he didn’t remove the endo because ‘it would cause more trouble than its worth’ and I was supposed to start gnrh analogue but due
Hey, was just wondering if someone could help. I had my diagnostic lap December 2019, where mild endo was found in pouch of Douglas and uterosacral ligaments. The doctor said he didn’t remove the endo because ‘it would cause more trouble than its worth’ and I was supposed to start gnrh analogue but due
Hayleyx07
in
Endometriosis UK
3 years ago
FDA has approved Relugolix (Orgovyx) for advanced PCa.
"The approval of the GnRH receptor antagonist is based on data from the phase 3 HERO study, which showed that 96.7% of patients randomized to relugolix maintained castration through 48 weeks, compared with 88.8% of patients receiving leuprolide (P <.001).1 The benefit with relugolix was sustained across
"The approval of the GnRH receptor antagonist is based on data from the phase 3 HERO study, which showed that 96.7% of patients randomized to relugolix maintained castration through 48 weeks, compared with 88.8% of patients receiving leuprolide (P <.001).1 The benefit with relugolix was sustained across
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Gynecomastia and ADT?
When I asked my URO about using 10 mg Tamoxifen for gynecomastia....she said the following: All of the studies I could find on using tamoxifen were in patients on biclutamide. As far as I understand, the GNRH antagonists shouldn't cause the same shift in the estrogen levels which is what causes the
When I asked my URO about using 10 mg Tamoxifen for gynecomastia....she said the following: All of the studies I could find on using tamoxifen were in patients on biclutamide. As far as I understand, the GNRH antagonists shouldn't cause the same shift in the estrogen levels which is what causes the
JPnSD
in
Advanced Prostate Cancer
4 years ago
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Prolonged period following hysteroscopy
- - - Update - - - My bleeding stopped at CD19. A follow up call with my gynae team said it was not uncommon for a longer cycle following a hysteroscopy. —————————————————————— Hi ladies, I hope you are all safe and well. I had a laparoscopy + hysteroscopy on 14th Nov in prep for a FET earlier next
- - - Update - - - My bleeding stopped at CD19. A follow up call with my gynae team said it was not uncommon for a longer cycle following a hysteroscopy. —————————————————————— Hi ladies, I hope you are all safe and well. I had a laparoscopy + hysteroscopy on 14th Nov in prep for a FET earlier next
KDA0510
in
Fertility Network UK
4 years ago
No endo
Hi guys! You have all been so amazing and I am just writing to see if there is anyone else in the same boat now. I've just been for a lap and they have said it is clear. I am obviously incredibly greatful not to have endo however, my symptoms still exist and I feel like I am about to be pushed into
Hi guys! You have all been so amazing and I am just writing to see if there is anyone else in the same boat now. I've just been for a lap and they have said it is clear. I am obviously incredibly greatful not to have endo however, my symptoms still exist and I feel like I am about to be pushed into
Ellyfant
in
Endometriosis UK
4 years ago
Recurrent diaphragmatic endometriosis
Dear ladies, Would you please help me? I am known endometriosis stage 4. I have diaphragmatic endometriosis and had previous lung collapse 3 years ago. I had laparoscopy as well 3 years ago and they removed large chocolate cyst and my left ovary, but never dealt with my diaphragm. Since then I have
Dear ladies, Would you please help me? I am known endometriosis stage 4. I have diaphragmatic endometriosis and had previous lung collapse 3 years ago. I had laparoscopy as well 3 years ago and they removed large chocolate cyst and my left ovary, but never dealt with my diaphragm. Since then I have
Endomy
in
Endometriosis UK
4 years ago
Bad gyn experience
Hi guys, I've just gotten out an appointment with a new gyny and was told that as I don't have acute pain there is no chance I have endo and that it's because I am overweight (which my GP has said is completely untrue as I am a healthy weight). I've been waiting 8 months for a laparoscopy now after
Hi guys, I've just gotten out an appointment with a new gyny and was told that as I don't have acute pain there is no chance I have endo and that it's because I am overweight (which my GP has said is completely untrue as I am a healthy weight). I've been waiting 8 months for a laparoscopy now after
Ellyfant
in
Endometriosis UK
4 years ago
Vagifem - Estradiol
Hello ladies, It’s been now a second month I’m being prescribed Vagifem. The hot flashes are getting stronger. The cold sweats are unbearable.... Also realised that each flare is lasting longer (spent 2 weeks unable to make a move).. I don’t know if it’s the fact that I was 2y under Decapeptyl (
Hello ladies, It’s been now a second month I’m being prescribed Vagifem. The hot flashes are getting stronger. The cold sweats are unbearable.... Also realised that each flare is lasting longer (spent 2 weeks unable to make a move).. I don’t know if it’s the fact that I was 2y under Decapeptyl (
Sorayaq
in
Endometriosis UK
4 years ago
Endo flare - Day 6...
Hi everyone, New here. I found myself having a massive flare lately... I was under GNRH for the past 4 years... and this year I have been referred to a specialist in the U.K. He decided that I needed to change my hormonotherapy (4y was too long). And I’m waiting for my surgery date.... (could take
Hi everyone, New here. I found myself having a massive flare lately... I was under GNRH for the past 4 years... and this year I have been referred to a specialist in the U.K. He decided that I needed to change my hormonotherapy (4y was too long). And I’m waiting for my surgery date.... (could take
Sorayaq
in
Endometriosis UK
4 years ago
Adenomyoma removal and gnrh
Hello everyone. I had a focal adenomyoma removed through laprascopy. Also had a few chocolate cysts and adhesions cleared at the same time. It was a pretty extensive surgery and I have a great doc. Unfortunately, I landed up catching an infection within a week and was back at the hospital on very heavy
Hello everyone. I had a focal adenomyoma removed through laprascopy. Also had a few chocolate cysts and adhesions cleared at the same time. It was a pretty extensive surgery and I have a great doc. Unfortunately, I landed up catching an infection within a week and was back at the hospital on very heavy
Saib26
in
Endometriosis UK
4 years ago
Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
New paper below [1]. I have watched plenty of videos where Neal Shore, Alicia Morgans & Charles Ryan get together at a conference to discuss the presentations that interested them. Here they are in a paper - can a video be far behind? I think that the paper addresses some issues that have often been
New paper below [1]. I have watched plenty of videos where Neal Shore, Alicia Morgans & Charles Ryan get together at a conference to discuss the presentations that interested them. Here they are in a paper - can a video be far behind? I think that the paper addresses some issues that have often been
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Zoladex and Tibolone
Hello all! I had my 3rd lap a month ago for endometriosis where they then put me on zoladex and tibolone. I had my first jab a week ago and ever since as well as hot flushes etc I have had the worst tiredness and complete brain fog I have ever experienced! I have had GNrh treatments before but don't
Hello all! I had my 3rd lap a month ago for endometriosis where they then put me on zoladex and tibolone. I had my first jab a week ago and ever since as well as hot flushes etc I have had the worst tiredness and complete brain fog I have ever experienced! I have had GNrh treatments before but don't
down_the_rabbit_hole
in
Endometriosis UK
4 years ago
Did everyone have to take a GNRH injection before their surgery . Usually its zoladex or prostap?
Advice please !
Advice please !
Endo_enemy
in
Endometriosis UK
4 years ago
A study of patient's choice of ADT: bicalutamide, a gonadotrophin-releasing hormone analogue or orchidectomy
As the title conveys, All three are a different form of ADT... merely because a person has circulating testosterone in their blood when taking bicalutamide doesn't mean bicalutamide is not a form of ADT or that they are able to use the testosterone even though they have it. My understanding is -
As the title conveys, All three are a different form of ADT... merely because a person has circulating testosterone in their blood when taking bicalutamide doesn't mean bicalutamide is not a form of ADT or that they are able to use the testosterone even though they have it. My understanding is -
George71
in
Advanced Prostate Cancer
4 years ago
IVF drugs Synarel and Decapepty caused menopause -has this happened to you?
This happened to me. I was menstruating and ovulating and had no menopausal symptoms except irregular periods sometimes shorter or longer or sometimes 28 days. I took Synarel from cd21 for a down regulation cycle and got the menopause symptoms within days but had to change to decapeptyl due to severe
This happened to me. I was menstruating and ovulating and had no menopausal symptoms except irregular periods sometimes shorter or longer or sometimes 28 days. I took Synarel from cd21 for a down regulation cycle and got the menopause symptoms within days but had to change to decapeptyl due to severe
JM888
in
Fertility Network UK
4 years ago
6-month Update: PSA down / Testosterone up
My father (67) has six month on Leuprolide+Bicalutamide, widespread bone mets. He wasnt fit for chemo and there is no Abiraterone or Enzalutamide in Venezuela, but he had a good response to ADT, and his last PSA came to 0,62 from 36 before treatment in march (but as high as 126 last december). He feels
My father (67) has six month on Leuprolide+Bicalutamide, widespread bone mets. He wasnt fit for chemo and there is no Abiraterone or Enzalutamide in Venezuela, but he had a good response to ADT, and his last PSA came to 0,62 from 36 before treatment in march (but as high as 126 last december). He feels
olloreda
in
Advanced Prostate Cancer
4 years ago
Metformin: Preliminary Results of Trial in Advanced Prostate Cancer (MANSMED)
Not sure if this was posted here yet: In a mini-oral presentation at this year’s European Society of Medical Oncology (ESMO) 2020 Virtual Annual Meeting, Dr. Reham Alghandour presented the results of the MANSMED prospective randomized controlled trial. This trial recruited men with high risk localized
Not sure if this was posted here yet: In a mini-oral presentation at this year’s European Society of Medical Oncology (ESMO) 2020 Virtual Annual Meeting, Dr. Reham Alghandour presented the results of the MANSMED prospective randomized controlled trial. This trial recruited men with high risk localized
noahware
in
Advanced Prostate Cancer
4 years ago
Restart GNRH injections
Hi, So I have recently had a flare up and have been told today that whilst I'm waiting for my operation I am to restart the GNRH injections. Has anyone done this and had any problems? I feel like they made me so much worse when I had them the first time round (although I had them for too long 1 year
Hi, So I have recently had a flare up and have been told today that whilst I'm waiting for my operation I am to restart the GNRH injections. Has anyone done this and had any problems? I feel like they made me so much worse when I had them the first time round (although I had them for too long 1 year
bonnieclyde97
in
Endometriosis UK
4 years ago
Free vs Total Testosterone? - Redux.
Cheerr had asked: "Which test is recommended for Pca patients - Total or Free." I belatedly remembered a German study [1] that took a look at the issue. This could be important - hence the new post. "Despite the fact that free testosterone (FT) is the biologically active form, it is common practice
Cheerr had asked: "Which test is recommended for Pca patients - Total or Free." I belatedly remembered a German study [1] that took a look at the issue. This could be important - hence the new post. "Despite the fact that free testosterone (FT) is the biologically active form, it is common practice
pjoshea13
in
Advanced Prostate Cancer
4 years ago
The pill and HRT after operation
Hi, hope everyone is safe and well. I've been on Gnrh prostape analogue injections for 12 months which have worked well despite a shaky start and so e side effects to HRT. I've had conflicting advice for my next stage of treatment in the hope I will go into a more natural menapause. Has anyone taken
Hi, hope everyone is safe and well. I've been on Gnrh prostape analogue injections for 12 months which have worked well despite a shaky start and so e side effects to HRT. I've had conflicting advice for my next stage of treatment in the hope I will go into a more natural menapause. Has anyone taken
Seren11
in
Endometriosis UK
4 years ago
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