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GnRH agonist
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Thought it was under control after years of multiple serious surgeries and diet changes but now facing new battles - any advice welcome
Hello all, I was diagnosed with endometriosis aged 21 after 8 years of awful problems and symptoms. After my first laparoscopy I was initially told it was “just a few spots of endometriosis” and my options were chemically induced menopause (gnrh and add back HRT) or to get pregnant and they fitted
Hello all, I was diagnosed with endometriosis aged 21 after 8 years of awful problems and symptoms. After my first laparoscopy I was initially told it was “just a few spots of endometriosis” and my options were chemically induced menopause (gnrh and add back HRT) or to get pregnant and they fitted
Greys90
in
Endometriosis UK
3 years ago
COMBAT-CRPC: COncurrent adMinistration of Bipolar Androgen Therapy and Nivolumab in men with mCRPC
First, an interview of Mark Markowski by Charles Ryan: https://www.urotoday.com/video-lectures/asco-2021/video/2204-concurrent-administration-of-bipolar-androgen-therapy-and-nivolumab-in-men-with-mcrpc-the-combat-study-mark-markowski.html ... then the ASCO presentation by Markowski : https://www.urotoday.com
First, an interview of Mark Markowski by Charles Ryan: https://www.urotoday.com/video-lectures/asco-2021/video/2204-concurrent-administration-of-bipolar-androgen-therapy-and-nivolumab-in-men-with-mcrpc-the-combat-study-mark-markowski.html ... then the ASCO presentation by Markowski : https://www.urotoday.com
pjoshea13
in
Advanced Prostate Cancer
3 years ago
tE2 – History, Sourcing, and obstacles in the US
These were the standard drugs for treatment of advanced prostate cancer for over forty years until the
GnRH
agonist
leuprorelin (Lupron) replaced them in 1985. In 1980, Sindell v.
These were the standard drugs for treatment of advanced prostate cancer for over forty years until the
GnRH
agonist
leuprorelin (Lupron) replaced them in 1985. In 1980, Sindell v.
ragnar2020
in
Advanced Prostate Cancer
3 years ago
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Gnrh injection reactions
Hi just after some advice and to see if anyone else has had this problem before. Had my second 3 monthly dose of prostap yesterday. The doctor who administered the injection wasn't my usual, I usually see the nurse. To start with she could not get the powder to melt in the syringe, then she couldn't
Hi just after some advice and to see if anyone else has had this problem before. Had my second 3 monthly dose of prostap yesterday. The doctor who administered the injection wasn't my usual, I usually see the nurse. To start with she could not get the powder to melt in the syringe, then she couldn't
Danaxx99
in
Endometriosis UK
3 years ago
What Would You Advise Please?
I am 72 years old living in Germany and still teaching out of existential needs. My wife is bedridden with heart insufficiency and in constant pain, with rheumatism We have a brilliant 11-year-old son to care for who is entering 11 grade. I have recently been diagnosed with aggressive prostate cancer
I am 72 years old living in Germany and still teaching out of existential needs. My wife is bedridden with heart insufficiency and in constant pain, with rheumatism We have a brilliant 11-year-old son to care for who is entering 11 grade. I have recently been diagnosed with aggressive prostate cancer
Rudradas
in
Advanced Prostate Cancer
3 years ago
What Would You Advise Please?
I am 72 years old living in Germany and still teaching out of existential needs. My wife is bedridden with heart insufficiency and in constant pain, with rheumatism We have a brilliant 11-year-old son to care for who is entering 11 grade. I have recently been diagnosed with aggressive prostate cancer
I am 72 years old living in Germany and still teaching out of existential needs. My wife is bedridden with heart insufficiency and in constant pain, with rheumatism We have a brilliant 11-year-old son to care for who is entering 11 grade. I have recently been diagnosed with aggressive prostate cancer
Hidden
in
Advanced Prostate Cancer
3 years ago
Is a hysterectomy inevitable?
I had my follow up consultation yesterday following extensive surgery (endo removed throughout the abdomen 'everywhere', a 10cm endometrioma, appendix, scar tissue, both tubes). Only diagnosed at 35 due to infertility investigations. Stage IV. I guess I was 'lucky; in that I didn't realize before and
I had my follow up consultation yesterday following extensive surgery (endo removed throughout the abdomen 'everywhere', a 10cm endometrioma, appendix, scar tissue, both tubes). Only diagnosed at 35 due to infertility investigations. Stage IV. I guess I was 'lucky; in that I didn't realize before and
Chicken1001
in
Endometriosis UK
3 years ago
Androgen Receptor Signalling Inhibitors – Post-Chemotherapy, Pre-Chemotherapy and now in castration sensitive prostate cancer - ERC -6.15.21
Androgen Receptor Signalling Inhibitors – Post-Chemotherapy, Pre-Chemotherapy and now in castration sensitive prostate cancer - Nicholas Mitsiades and Salma Kaochar, Dept. of Medicine and Dept. of Molecular and Cellular Biology, Baylor College of Medicine, Houston,TX 77030. Accepted Manuscript published
Androgen Receptor Signalling Inhibitors – Post-Chemotherapy, Pre-Chemotherapy and now in castration sensitive prostate cancer - Nicholas Mitsiades and Salma Kaochar, Dept. of Medicine and Dept. of Molecular and Cellular Biology, Baylor College of Medicine, Houston,TX 77030. Accepted Manuscript published
cujoe
in
Fight Prostate Cancer
3 years ago
Broken and Lost - awaiting urgent hysterectomy at 34
Today broke me!! My surgeon phoned for an over the phone consult (thanks covid) if you know my story I’ve been waiting since 2017 for a hysterectomy due to stage 4 or as I call it decimated stage Endo. I haven’t even met him in person since I was ‘urgently’ referred Nov 19! And he’s called twice both
Today broke me!! My surgeon phoned for an over the phone consult (thanks covid) if you know my story I’ve been waiting since 2017 for a hysterectomy due to stage 4 or as I call it decimated stage Endo. I haven’t even met him in person since I was ‘urgently’ referred Nov 19! And he’s called twice both
Endo_Jaded
in
Endometriosis UK
3 years ago
Why are cardiac effects different for GnRH agonists and antagonists?
I've always been troubled by the observation that GnRH agonists (like Lupron, Gosarelix, Zoladex, and Triptorelin) had a high risk of cardiotoxicity while GnRH antagonists (Firmagon and Orgovyx) did not. Why should they be different if they both lower testosterone? This RCT offers a good explanation.
I've always been troubled by the observation that GnRH agonists (like Lupron, Gosarelix, Zoladex, and Triptorelin) had a high risk of cardiotoxicity while GnRH antagonists (Firmagon and Orgovyx) did not. Why should they be different if they both lower testosterone? This RCT offers a good explanation.
Tall_Allen
in
Advanced Prostate Cancer
3 years ago
Mid York’s BSGE referral and more
Hello fellow endo warriors, Has anyone any experience of getting referred to the mid York’s trust BSGE centre at Pinderfields? My consultant gynaecologist (at Bradford) wants to do a diagnostic laparoscopy to confirm stage 4 endo and bowel implications. She won’t just perform a hysterectomy despite me
Hello fellow endo warriors, Has anyone any experience of getting referred to the mid York’s trust BSGE centre at Pinderfields? My consultant gynaecologist (at Bradford) wants to do a diagnostic laparoscopy to confirm stage 4 endo and bowel implications. She won’t just perform a hysterectomy despite me
Astro_kat
in
Endometriosis UK
3 years ago
Testosterone therapy to... LOWER testosterone production?
I know there is plenty of talk here about BAT and TRT and SPT (i.e., supra-physiological levels of testosterone) , but there is an aspect of getting high-T shots that sometimes gets mentioned without in-depth discussion. Namely, that high doses of exogenous T can serve to suppress the endogenous (testicular
I know there is plenty of talk here about BAT and TRT and SPT (i.e., supra-physiological levels of testosterone) , but there is an aspect of getting high-T shots that sometimes gets mentioned without in-depth discussion. Namely, that high doses of exogenous T can serve to suppress the endogenous (testicular
noahware
in
Advanced Prostate Cancer
3 years ago
Neuroendocrine cells.
New (to PubMed, but published in January) paper below. [1] "As androgen receptor (AR) signaling is critical for the proliferation and metabolic functions of prostatic tumor cells, the mainstay of treatment is hormonal therapy, aimed at reducing the systemic level of circulating androgens (i.e. GnRH agonists
New (to PubMed, but published in January) paper below. [1] "As androgen receptor (AR) signaling is critical for the proliferation and metabolic functions of prostatic tumor cells, the mainstay of treatment is hormonal therapy, aimed at reducing the systemic level of circulating androgens (i.e. GnRH agonists
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Anybody had multiple surgeries to remove endo, then total hysterectomy?
I'm trying to get some advice from any ladies who have had multiple laparoscopies to remove endometriosis and then ended up eventually having a total hysterectomy (uterus + ovaries removed). How did you decide when it was enough and then decide to have the hysterectomy? At what age did you decide on
I'm trying to get some advice from any ladies who have had multiple laparoscopies to remove endometriosis and then ended up eventually having a total hysterectomy (uterus + ovaries removed). How did you decide when it was enough and then decide to have the hysterectomy? At what age did you decide on
ciaotuffy
in
Endometriosis UK
3 years ago
Extreme side-effects from ADT
Anyone have a clue whether the following rapid deterioration can be a result of ADT? My fasting glucose went from excellent 78 mg/dL = 4.4 mmol/l to almost diabetic 123 mg/dl = 6.9 mmol/L. in stages in the space of not much more than a single month, after five months of Firmagon. Tested twice last
Anyone have a clue whether the following rapid deterioration can be a result of ADT? My fasting glucose went from excellent 78 mg/dL = 4.4 mmol/l to almost diabetic 123 mg/dl = 6.9 mmol/L. in stages in the space of not much more than a single month, after five months of Firmagon. Tested twice last
Purple-Bike
in
Advanced Prostate Cancer
3 years ago
Is it possible to have endometriosis and still feel pain while on hormone treatments?
I have tried two types of the pill, the GnRH analogues (Zoladex injections) and I have had the mirena coil implanted for the last seven weeks. While on all three I have still felt horrible pain in my womb. I am just wondering if hormones always work or if there may be some women who just don't respond
I have tried two types of the pill, the GnRH analogues (Zoladex injections) and I have had the mirena coil implanted for the last seven weeks. While on all three I have still felt horrible pain in my womb. I am just wondering if hormones always work or if there may be some women who just don't respond
tullagh
in
Endometriosis UK
3 years ago
GnRH analogue
Hello. Does anyone have any experience of GnRH analogues? They are injections that stop your periods to give you some relief. It’s temporary for 3-6 months. Just wondered what the side effects were. Also any experience of Tibolone (Livial). It’s an HRT tablet to help manage side effects of injections
Hello. Does anyone have any experience of GnRH analogues? They are injections that stop your periods to give you some relief. It’s temporary for 3-6 months. Just wondered what the side effects were. Also any experience of Tibolone (Livial). It’s an HRT tablet to help manage side effects of injections
Summer-2021
in
Endometriosis UK
3 years ago
Post operative treatment options, help!
Hey, Here goes my life story... On the 10th of February I had a laparoscopy surgery to investigate pelvic pain and an ovarian cyst. I was discharged on the same day only being told I had endometriosis and it was severe. I left not knowing much about the disease at all. Fast forward 4 weeks (and a
Hey, Here goes my life story... On the 10th of February I had a laparoscopy surgery to investigate pelvic pain and an ovarian cyst. I was discharged on the same day only being told I had endometriosis and it was severe. I left not knowing much about the disease at all. Fast forward 4 weeks (and a
Krissie25
in
Endometriosis UK
3 years ago
Norethisterone LDR
Has anyone ever taken norethisterone after ovulation to try and collect two groups of follicles in a stim cycle? So right after you ovulate, start the norethisterone and then after 14 days stop, have a bleed, then start stim? so like a milder long down reg cycle with norethisterone instead of a GNRH.
Has anyone ever taken norethisterone after ovulation to try and collect two groups of follicles in a stim cycle? So right after you ovulate, start the norethisterone and then after 14 days stop, have a bleed, then start stim? so like a milder long down reg cycle with norethisterone instead of a GNRH.
Curious123
in
Fertility Network UK
3 years ago
GnRH Injections
Hi! I'm currently being investigated for endo and my gynae wants me to try GnRH analogues (prostap or zolaplex) to treat some bowel growths she thinks I have. I was wondering if anyone else had experience of this treatment and how they found it? Thanks in advance!
Hi! I'm currently being investigated for endo and my gynae wants me to try GnRH analogues (prostap or zolaplex) to treat some bowel growths she thinks I have. I was wondering if anyone else had experience of this treatment and how they found it? Thanks in advance!
endomedstudent
in
Endometriosis UK
3 years ago
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