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Update on failing Enzalutamide
Do people concur with my onco, that once
Enzalutamide
has failed, it's really not worth pursuing the other 'mides'? 2. Can anyone recommend men on here who have travelled to Australia for Lu-177 treatment, so that I can pick their brains? 3.
Do people concur with my onco, that once
Enzalutamide
has failed, it's really not worth pursuing the other 'mides'? 2. Can anyone recommend men on here who have travelled to Australia for Lu-177 treatment, so that I can pick their brains? 3.
CrocodileShoes
in
Advanced Prostate Cancer
1 year ago
PSA suppression
Incidentally, that phrase - rapid androgen cycling - brings to mind the work of Howard Scher [3] (2006) When Abiraterone and
Enzalutamide
were approved, I was briefly tempted. But however efficient they were at controlling PSA, the effects were transient for most men.
Incidentally, that phrase - rapid androgen cycling - brings to mind the work of Howard Scher [3] (2006) When Abiraterone and
Enzalutamide
were approved, I was briefly tempted. But however efficient they were at controlling PSA, the effects were transient for most men.
pca2004
in
Fight Prostate Cancer
7 months ago
Abiraterone - alternatives
In the UK once you’ve been on Abi for 3 months you can’t get
Enzalutamide
- should we therefore be asking for Enza before the 3 months are up ? Note- when we asked the onco this question he said if the Abi fails the Enza will fail.
In the UK once you’ve been on Abi for 3 months you can’t get
Enzalutamide
- should we therefore be asking for Enza before the 3 months are up ? Note- when we asked the onco this question he said if the Abi fails the Enza will fail.
NLondon43
in
Advanced Prostate Cancer
1 year ago
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Enzalutamide & 5-year survival in mHSPC.
-Patrick [1] https://www.urologytimes.com/view/
enzalutamide
-sustains-survival-benefit-in-mhspc-with-over-5-years-follow-up [2] https://www.urologytimes.com/view/dr-ian-davis-on-5-year-
enzalutamide
-survival-data-in-mhspc
-Patrick [1] https://www.urologytimes.com/view/
enzalutamide
-sustains-survival-benefit-in-mhspc-with-over-5-years-follow-up [2] https://www.urologytimes.com/view/dr-ian-davis-on-5-year-
enzalutamide
-survival-data-in-mhspc
pca2004
in
Fight Prostate Cancer
1 year ago
Darolutamide & time to treatment discontinuation in nmCRPC
metastatic castration-resistant prostate cancer (mCRPC) vs
enzalutamide
and apalutamide.
metastatic castration-resistant prostate cancer (mCRPC) vs
enzalutamide
and apalutamide.
pca2004
in
Fight Prostate Cancer
1 year ago
Enza + lutetium?
https://www.urotoday.com/video-lectures/esmo-2023/video/mediaitem/3699-enza-p-trial-shows-promise-for-
enzalutamide
-lutetium-combination-in-prostate-cancer-louise-emmett.html
https://www.urotoday.com/video-lectures/esmo-2023/video/mediaitem/3699-enza-p-trial-shows-promise-for-
enzalutamide
-lutetium-combination-in-prostate-cancer-louise-emmett.html
Maxone73
in
Advanced Prostate Cancer
7 months ago
? For fellow BATmen on daro and androgen stimulation. Great Article
Importantly, darolutamide is structurally different from other second-generation AR antagonists, such as
enzalutamide
and apalutamide.
Importantly, darolutamide is structurally different from other second-generation AR antagonists, such as
enzalutamide
and apalutamide.
KocoPr
in
Fight Prostate Cancer
9 months ago
Oligomets and SBRT: "Whack a Mole"?
Then clinicians will be considering agents approved in the metastatic castration sensitive prostate cancer (mCSPC) such as docetaxel, apalutamide,
enzalutamide
, or abiraterone.
Then clinicians will be considering agents approved in the metastatic castration sensitive prostate cancer (mCSPC) such as docetaxel, apalutamide,
enzalutamide
, or abiraterone.
FrankyB4
in
Advanced Prostate Cancer
10 months ago
Clinical trial news
Saruparib (AZD5305) vs Placebo in Men with Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01 This is looking at whether adding a new drug on top of taking an Androgen Receptor Target Therapy (ARAT; such as abiraterone, darolutamide,
enzalutamide
Saruparib (AZD5305) vs Placebo in Men with Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01 This is looking at whether adding a new drug on top of taking an Androgen Receptor Target Therapy (ARAT; such as abiraterone, darolutamide,
enzalutamide
Max24
in
Advanced Prostate Cancer
3 months ago
Prostate Cancer and Statins
I came acoss this article which seems to suggest that simvastatin in particular can enhance the effects of
enzalutamide
. Should I cheerfully now capitulate, show my GP the article, and ask to go on simvastatin? Thoughts/observations, chaps?
I came acoss this article which seems to suggest that simvastatin in particular can enhance the effects of
enzalutamide
. Should I cheerfully now capitulate, show my GP the article, and ask to go on simvastatin? Thoughts/observations, chaps?
john510185
in
Advanced Prostate Cancer
1 year ago
Latest Treatments for Advanced Prostate Cancer
Enzalutamide
has been shown to improve survival and delay cancer progression in men with advanced prostate cancer who have previously received hormone therapy or chemotherapy6 .
Enzalutamide
was approved by the FDA in 2012 for this group of men.
Enzalutamide
has been shown to improve survival and delay cancer progression in men with advanced prostate cancer who have previously received hormone therapy or chemotherapy6 .
Enzalutamide
was approved by the FDA in 2012 for this group of men.
NecessarilySo
in
Advanced Prostate Cancer
1 year ago
Rechallenging with a previously failed treatment?
But, haven't heard about their possible benefit/success/failure except for a trial that failed for me using a triple combo of Actinium/Keytruda/
Enzalutamide
.
But, haven't heard about their possible benefit/success/failure except for a trial that failed for me using a triple combo of Actinium/Keytruda/
Enzalutamide
.
HopingForTheBest1
in
Advanced Prostate Cancer
1 year ago
Enzalutamide & ARCHES trial.
More from ASCO 2023 [1]: “We found in ARCHES that in the men who developed radiographic progression while on ADT-
enzalutamide
[Xtandi], two thirds of these patients, when they had radiographic progression, did not meet PSA progression criteria, and one third didn't have any rise at all in their PSA,
More from ASCO 2023 [1]: “We found in ARCHES that in the men who developed radiographic progression while on ADT-
enzalutamide
[Xtandi], two thirds of these patients, when they had radiographic progression, did not meet PSA progression criteria, and one third didn't have any rise at all in their PSA,
pca2004
in
Fight Prostate Cancer
1 year ago
Xtandi monotherapy is very effective
The
enzalutamide
monotherapy was almost as effective as
enzalutamide
plus leuprolide with fewer hot flushes, hypertension, falls and fractures. The reduced fractures show that the monotherapy avoids bone loss. Therefore, Xgeva is probably not required.
The
enzalutamide
monotherapy was almost as effective as
enzalutamide
plus leuprolide with fewer hot flushes, hypertension, falls and fractures. The reduced fractures show that the monotherapy avoids bone loss. Therefore, Xgeva is probably not required.
GP24
in
Advanced Prostate Cancer
1 year ago
doc says 9-12 months more for my dad
He was diagnosed with PCa in November - started triplet therapy right away (Docetaxel,
Enzalutamide
& degarelix) his PSA dropped to negligible from over 200. he started experiencing pain in his abdomen last month or so.
He was diagnosed with PCa in November - started triplet therapy right away (Docetaxel,
Enzalutamide
& degarelix) his PSA dropped to negligible from over 200. he started experiencing pain in his abdomen last month or so.
A-rat-22
in
Advanced Prostate Cancer
1 year ago
Final STAMPEDE results for Abi with/out Enza when starting ADT.
We have not formally compared the abiraterone and
enzalutamide
trial with trials testing
enzalutamide
. But, given the similar efficacy reported when combining
enzalutamide
with androgen deprivation therapy, we also conclude that combining abiraterone with
enzalutamide
would not be more effective.
We have not formally compared the abiraterone and
enzalutamide
trial with trials testing
enzalutamide
. But, given the similar efficacy reported when combining
enzalutamide
with androgen deprivation therapy, we also conclude that combining abiraterone with
enzalutamide
would not be more effective.
pca2004
in
Fight Prostate Cancer
1 year ago
Need help to fight fatigue from Radium 223
After this will likely have to switch to
Enzalutamide
and ADT. Now having bad fatigue issues; on scale of 1 -10, my fatigue level is 2 - 3. For last 3 years fatigue level was 6 - 7. Any recommendations of beneficial supplements or meds to help improve fatigue level? .... Thanks
After this will likely have to switch to
Enzalutamide
and ADT. Now having bad fatigue issues; on scale of 1 -10, my fatigue level is 2 - 3. For last 3 years fatigue level was 6 - 7. Any recommendations of beneficial supplements or meds to help improve fatigue level? .... Thanks
Ronnie7C
in
Advanced Prostate Cancer
1 year ago
Should I fight for Darolutamide ?
I will restart Zoladex, and MO is adding
Enzalutamide
this time. My main concern is about cognitive SEs, since I work full time as a Software Enginner, my job depends of my brain.
I will restart Zoladex, and MO is adding
Enzalutamide
this time. My main concern is about cognitive SEs, since I work full time as a Software Enginner, my job depends of my brain.
CarlosBrasil
in
Advanced Prostate Cancer
1 year ago
My reaction to Crestor & Nubeqa combo. I need to make some adjustments. This study says simvastatin is best against APC. Your thoughts?
In castration-resistant LNCaPabl cells,
enzalutamide
combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of
enzalutamide
in 22Rv1 cells.
In castration-resistant LNCaPabl cells,
enzalutamide
combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of
enzalutamide
in 22Rv1 cells.
GeorgeGlass
in
Fight Prostate Cancer
1 year ago
Enzalutamide plus leuprolide reduces risk of metastasis in nonmetastatic HSPC men-from Urology Times, 29 Apr 2023
The median MFS was NR (95% CI, NR-NR) in the
enzalutamide
monotherapy arm.
The median MFS was NR (95% CI, NR-NR) in the
enzalutamide
monotherapy arm.
Balsam01
in
Advanced Prostate Cancer
1 year ago
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