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Experiences with
Enzalutamide
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Using Provenge before AR inhibitors.
https://www.urologytimes.com/view/sipuleucel-t-boosts-survival-versus-abiraterone-or-
enzalutamide
-alone-in-real-world-mcrpc-analysis
https://www.urologytimes.com/view/sipuleucel-t-boosts-survival-versus-abiraterone-or-
enzalutamide
-alone-in-real-world-mcrpc-analysis
dhccpa
in
Advanced Prostate Cancer
2 months ago
The University of California has raked in a previously undisclosed $1.6 billion from Xtandi sales sales
UCLA chemist Michael Jung designed a molecule called
enzalutamide
, known commercially as Xtandi.
UCLA chemist Michael Jung designed a molecule called
enzalutamide
, known commercially as Xtandi.
rsgdmd
in
Advanced Prostate Cancer
3 months ago
The Science is Coming
Good to see the mini AZD5069 trial with
enzalutamide
offering another route to taming the beast. I am no scientist but as I understand it the target is myeloid white blood cells which can act to fuel tumours.
Good to see the mini AZD5069 trial with
enzalutamide
offering another route to taming the beast. I am no scientist but as I understand it the target is myeloid white blood cells which can act to fuel tumours.
GreenStreet
in
Prostate Cancer Network
9 months ago
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Post Degaralix
I know it’s doing it’s thing, along with
enzalutamide
but feeling my quality of life balance is tipping to far the other way. Hoping I’ll feel differently by the end of today.
I know it’s doing it’s thing, along with
enzalutamide
but feeling my quality of life balance is tipping to far the other way. Hoping I’ll feel differently by the end of today.
FortyWinks
in
Advanced Prostate Cancer
10 months ago
Need help understanding Enzalutamide
Help us understand what to expect with the SE of
Enzalutamide
. Soapchick
Help us understand what to expect with the SE of
Enzalutamide
. Soapchick
Hidden
in
Advanced Prostate Cancer
11 months ago
ADT or not?
Hi, i have Stage 4 PCA, Gleason 5+4 so I am on Degaralix and
Enzalutamide
. I tend to refer to this treatment as ADT as shorthand because to my mind they both reduce testosterone. I wonder if I’m misusing ADT or does it matter?
Hi, i have Stage 4 PCA, Gleason 5+4 so I am on Degaralix and
Enzalutamide
. I tend to refer to this treatment as ADT as shorthand because to my mind they both reduce testosterone. I wonder if I’m misusing ADT or does it matter?
FortyWinks
in
Advanced Prostate Cancer
11 months ago
New combo shows promising results in clinical trial: enzalutamide plus CC-115
https://www.x-mol.net/paper/article/1726434947306901504
https://www.x-mol.net/paper/article/1726434947306901504
Maxone73
in
Advanced Prostate Cancer
8 months ago
More Evidence Linking ADT for PCa to Adverse Neurocognitive Effects -Meta-analysis shows increased risk of dementia, Parkinson's, depression
The risk was even higher in men treated with newer androgen receptor signaling inhibitors (ARSIs), but the association was not consistent across the ARSI class: increased risk with
enzalutamide
(Xtandi) and apalutamide (Erleada) but decreased risk with abiraterone (Zytiga).
The risk was even higher in men treated with newer androgen receptor signaling inhibitors (ARSIs), but the association was not consistent across the ARSI class: increased risk with
enzalutamide
(Xtandi) and apalutamide (Erleada) but decreased risk with abiraterone (Zytiga).
cujoe
in
Fight Prostate Cancer
6 months ago
Xtandi and insomnia
Anybody else have severe insomnia from
enzalutamide
? I'm only getting ~3 hours sleep since starting. Pretty deep fatigue too. Any advice on ways to manage this?
Anybody else have severe insomnia from
enzalutamide
? I'm only getting ~3 hours sleep since starting. Pretty deep fatigue too. Any advice on ways to manage this?
Djangler
in
Advanced Prostate Cancer
1 year ago
AUA 2023: PSA Response and Time-to-Castration Resistance Among Patients with mCSPCa Initiated on Apalutamide, Enzalutamide, or Abiraterone
on all measures
enzalutamide
ranked 2nd on all measures abiraterone ranked 3rd on all measures ------------------------------------------------------- [u]How much should I care?
on all measures
enzalutamide
ranked 2nd on all measures abiraterone ranked 3rd on all measures ------------------------------------------------------- [u]How much should I care?
skiingfiend
in
Advanced Prostate Cancer
11 months ago
BAT Patient Guide
"A larger randomized study comparing overall patient survival following treatment with sequential BAT → Xtandi versus
enzalutamide
or chemotherapy alone will be required to obtain FDA approval of this approach.
"A larger randomized study comparing overall patient survival following treatment with sequential BAT → Xtandi versus
enzalutamide
or chemotherapy alone will be required to obtain FDA approval of this approach.
dhccpa
in
Advanced Prostate Cancer
10 months ago
Switching from Abi to Enza?
My father has become pre-diabetic now and the doctor has advised to switch to
Enzalutamide
as it has fewer side effects. I wanted to check if anyone else did something like this (switching to Enza when Abi is still working), and whether you think this is a good idea? Many thanks in advance.
My father has become pre-diabetic now and the doctor has advised to switch to
Enzalutamide
as it has fewer side effects. I wanted to check if anyone else did something like this (switching to Enza when Abi is still working), and whether you think this is a good idea? Many thanks in advance.
Rodeoz15
in
Advanced Prostate Cancer
10 months ago
Very promising trial!
They were given a combination of AZD5069, an experimental drug that prevents white blood cells from being dragged inside tumours, and
enzalutamide
, a hormone therapy commonly used to treat prostate cancer.
They were given a combination of AZD5069, an experimental drug that prevents white blood cells from being dragged inside tumours, and
enzalutamide
, a hormone therapy commonly used to treat prostate cancer.
Maxone73
in
Advanced Prostate Cancer
9 months ago
Just been told I have two years to live.
Since then, been on
Enzalutamide
(sourced from India). No side effects except exhaustion. Too early to tell if working. Yesterday, oncologist said I have two years to live. PSA 135. Totally shocked. Anyone had similar experience? Is it worth getting a second opinion? Any suggestions?
Since then, been on
Enzalutamide
(sourced from India). No side effects except exhaustion. Too early to tell if working. Yesterday, oncologist said I have two years to live. PSA 135. Totally shocked. Anyone had similar experience? Is it worth getting a second opinion? Any suggestions?
ChristopherM123
in
Advanced Prostate Cancer
11 months ago
ONCT-534 Earns FDA Fast Track Designation in R/R Metastatic CRPC
“The receipt of fast track designation for ONCT-534 supports our belief that patients with [metastatic] CRPC who relapse after treatment with androgen receptor pathway inhibitors [ARPIs] such as
enzalutamide
[Xtandi] or abiraterone [Zytiga], represent an important unmet medical need,” James Breitmeyer
“The receipt of fast track designation for ONCT-534 supports our belief that patients with [metastatic] CRPC who relapse after treatment with androgen receptor pathway inhibitors [ARPIs] such as
enzalutamide
[Xtandi] or abiraterone [Zytiga], represent an important unmet medical need,” James Breitmeyer
Scout4answers
in
Advanced Prostate Cancer
9 months ago
Radium223 has not been a success, is Enzalutamide a good next option?
Now doctors are suggesting that possible option is to switch onto Xtandi/
Enzalutamide
. Anyone in the same or similar situation? Any advice would be welcomed .... Thanks
Now doctors are suggesting that possible option is to switch onto Xtandi/
Enzalutamide
. Anyone in the same or similar situation? Any advice would be welcomed .... Thanks
Ronnie7C
in
Advanced Prostate Cancer
11 months ago
My Small PCa Cells Don't Produce PSA
Bio/history summary : - Dx Gleason 8 seven years ago - Prostate tumour metastasis to seminal vesicules and pelvic lymph nodes - PSA from about 150 to undetectable after ADT,
enzalutamide
, and 6 x docetaxal Now - March scans showed progression so
enzalutamide
stopped - 7 cm tumour on hip, and others
Bio/history summary : - Dx Gleason 8 seven years ago - Prostate tumour metastasis to seminal vesicules and pelvic lymph nodes - PSA from about 150 to undetectable after ADT,
enzalutamide
, and 6 x docetaxal Now - March scans showed progression so
enzalutamide
stopped - 7 cm tumour on hip, and others
Bandit99
in
Advanced Prostate Cancer
1 year ago
Dual ARi in mCRPCa - Antonarakis = 'Combo of 2 AR-directed agents should not be utilized in clinical practice at this time', MedPage 7/20/23
Abiraterone targets extra-gonadal androgen synthesis, while
enzalutamide
directly targets the androgen receptor.
Abiraterone targets extra-gonadal androgen synthesis, while
enzalutamide
directly targets the androgen receptor.
cujoe
in
Fight Prostate Cancer
1 year ago
Enzalutamide (Xtandi): Start at half standard dose to extend efficacy time span?
Would this possibly extend the overall efficacy life span of
enzalutamide
? I am fit, very active and pain and side effect free apart from peripheral neuropathy in my feet caused by the chemo. I look forward to your views, experience with Xtandi and advice. Thank you. KGU
Would this possibly extend the overall efficacy life span of
enzalutamide
? I am fit, very active and pain and side effect free apart from peripheral neuropathy in my feet caused by the chemo. I look forward to your views, experience with Xtandi and advice. Thank you. KGU
KGU1
in
Advanced Prostate Cancer
10 months ago
Talzenna approved by FDA
The results of the trial showed statistically significant improvement in radiographic progression-free survival (rPFS) for Talzenna with
enzalutamide
versus placebo.
The results of the trial showed statistically significant improvement in radiographic progression-free survival (rPFS) for Talzenna with
enzalutamide
versus placebo.
Magnus1964
in
Prostate Cancer Network
1 year ago
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