Has anyone been offered, or tried, rechallenging with a previously failed treatment either by itself or in combination with a drug not tried before? For example, I was on Olaparib (being BRCA2+) successfully for 18 months before it failed.
Now there are treatments/trials combining Olaparib with another med like Abiraterone, which I had also previously failed as a mono therapy. Could a combo now possibly benefit me??? The answer may simply be that you won't know until you try.
Also, I have been hearing more and more about dual and triple therapies in lieu of mono therapies. But, haven't heard about their possible benefit/success/failure except for a trial that failed for me using a triple combo of Actinium/Keytruda/Enzalutamide.
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HopingForTheBest1
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My oncologist has me on 50% Docetaxel and 80% Carboplatin every 4 weeks, but was told due to my low platelet count and neuropathy. I’ve been on this plan stay late January since failing Plevicto. My psa at that time was 740 and is now down to 176….
I would love to try Xtandi again but onc doesn’t seem to want to go that route..
I think you are in the NY city area ? So Buffalo might be too far for you. The first 5 "checkups" are weekly. Then every 2 weeks for a month then every 3 weeks etc.
I'm in the phase 2 expansion trial and I dont have the CYP11A1 marker which those with it "might" have had better response in the phase 1 trial (smaller number in phase one trial with CYP11A1 marker than those without it).
I have tolerated the treatment well. My PSA has been on a slow rise during the month and a half or more on this trial but I feel good. First scans tomorrow so looking forward to that. My painful mets may or may not (hard to tell) be improved. Not worse anyway.
Ah ...well. At the time the availability of Pluvitco was still in question and this seemed a nice bridge until available or if lucky this could be a beneficial long term treatment if it works out. Also a rechallenge with Docetaxel this winter didnt go well for me. 3 1/2 years ago I had benifit from it and expected SE's. This winter no benefit and really bad SE's after 3 infusions so this "pill" of steroidal blockage was/is allowed me to recover from chemo as it has little if any SE's for me.
When I read the mechanisms of action for this drug I found it to seem very promising. I eventually reached the failure point with Zytiga and reached failure quick with Xtandi after chemo this winter.
This trial drug goes beyond our current 2nd generation ADT drugs in its steroidal interactions (blocking production,etc.). The ASCO link has more explanation than the trial.gov link.
This is the second trial I've been in and of course as you know too the trials represent a lot of good testing and care as well. Always a nice benefit.
Also on trial nice to be somewhat stable and not using up a SOC treatment.
I was rechallenged with Enza after 2 years on Olaparib, PSA down from 7.3 to 0.5 after two weeks of use. I have had BAT for three months before.
Just IMO, whatever Tall Alen said is good as gold.
Where do you go for treatment, the Onc Doc should be able to go over some trial results with you as pertains to your particiular case.advise you best. Keep the faith Brother!
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Rapid PSA, Failed Treatment.
Failed all gold standard treatments and both Chemos? Whats next?
Lu 177 also failed after 6 Cycles. 16 rounds of Chemo (10 Docxetexal and 6 Jevtana) previously failed. What could be next?
Could I try BAT to restore sensitivity to previously used antiandrogen treatments. 
