I am possibly going to be taking Avuelity for MDD . I was doing some research on it because of the RLS. There was one article of a woman with RLS who was given Dextromethirphan for a cough and got significant reduction in her symptoms, to the point she stopped Gaba and kept going with the dextromethorphan. Due to cost Dextro was stopped and she was started on Tramadol.
De tromethirphan is a MDNA antagonist so inhibits the glutamate system, so it makes some sense. It has to be paired with Buproprion specifically to keep the Dextrose from metabolizing so quickly. Many Dr’s will give the lowest dose Buproprion 150mg and have the patient buyDextromethirphan over the counter which is very inexpensive. Avuelity is 1200/ month!
Anybody out there tried this?
Written by
teakabeagle
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The only info I found was the article that testeyRestRest posted. Anecdotal only. Dextromethorphan is an MNDA inhibitor and blocks glutamate at the presynaotic level. Glutamate is involved in the inflammatory process and implicated in RLS. Ketamine is another NMDA inhibitor and has shown to improve RLS symptoms, but requires medical supervision due to the dissociative effects.
Meeting mid June with my RLS doc and psychiatrist to discuss using trying it for the MDD with my current low dose Buprenorophine.
What I wonder is why the DXM was discontinued for cost reasons. Here in Germany, the active ingredient is contained in some non-prescription cough suppressants. These are all very cheap and probably also have a more favorable side effect profile than tramadol
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