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Malecare newsletter reports Finish study glucocorticoids (e.g. prednisone, prednisolone, dexamethasone) can lead to castrate resistance
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
Graham49
in
Advanced Prostate Cancer
27 days ago
Docetaxel guideline for Prostate cancer
Also what is the dosage and duration of prednisolone and
dexamethasone
given during chemo? Thanks.
Also what is the dosage and duration of prednisolone and
dexamethasone
given during chemo? Thanks.
Samani
in
Advanced Prostate Cancer
1 year ago
n plate don't work after covid
I've been on n plate for 3 years and it was working until 2 months ago when I got sick from corona virus very lightly but a week later the platelets dropped to 10 and they don't go up only with
dexamethasone
for a while and again 10 and below, does anyone have a similar experience? thank you
I've been on n plate for 3 years and it was working until 2 months ago when I got sick from corona virus very lightly but a week later the platelets dropped to 10 and they don't go up only with
dexamethasone
for a while and again 10 and below, does anyone have a similar experience? thank you
lianaki
in
ITP Support Association
1 year ago
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Rituximab- my experience.
I had Rituximab +
dexamethasone
+cyclophosphamide after that for 12 cycles over 10 months. (I had bad nausea with the cyclophosphamide for up to a week after each infusion). Remission again only lasted around 3 months.
I had Rituximab +
dexamethasone
+cyclophosphamide after that for 12 cycles over 10 months. (I had bad nausea with the cyclophosphamide for up to a week after each infusion). Remission again only lasted around 3 months.
Hidden
in
CLL Support
8 months ago
Mandibular (trigeminal) nerve interference... relief?
In the meantime, this discomfort has not fully responded to any of the meds I am currently taking, and getting great responses from, for all the other pains (back, nerve, etc.) that have arisen recently: gabapentin, oxycodone, tylenol,
dexamethasone
, and THC.
In the meantime, this discomfort has not fully responded to any of the meds I am currently taking, and getting great responses from, for all the other pains (back, nerve, etc.) that have arisen recently: gabapentin, oxycodone, tylenol,
dexamethasone
, and THC.
noahware
in
Advanced Prostate Cancer
1 year ago
Two years and counting
One other trick he mentioned was switching Prednisone to
Dexamethasone
. Two treatment strategies he said were dead, Thorium Th 227 anti-PSMA monoclonal anti body and Amgen AMG 509. Here's hoping for another 2 years.
One other trick he mentioned was switching Prednisone to
Dexamethasone
. Two treatment strategies he said were dead, Thorium Th 227 anti-PSMA monoclonal anti body and Amgen AMG 509. Here's hoping for another 2 years.
Skippy3
in
Advanced Prostate Cancer
1 year ago
Looking for more wholistic answers to dealing with ITP
Last week they put me on a short dose of
dexamethasone
which helped and now I am getting Nplate injections weekly for a month. From everything I have read, I cannot find a rhyme or a reason or any sure way of treating or predicting this disease.
Last week they put me on a short dose of
dexamethasone
which helped and now I am getting Nplate injections weekly for a month. From everything I have read, I cannot find a rhyme or a reason or any sure way of treating or predicting this disease.
bonandmick
in
ITP Support Association
1 year ago
Started Triplet Therapy this week, new doc, new (better) treatment plan!
We reviewed side effects, and he is agreeable , I prescribed
dexamethasone
and explained the schedule for this. I would like to use the triplet regimen from ARASENS, so I have prescribed darolutamide.
We reviewed side effects, and he is agreeable , I prescribed
dexamethasone
and explained the schedule for this. I would like to use the triplet regimen from ARASENS, so I have prescribed darolutamide.
Gl448
in
Advanced Prostate Cancer
1 year ago
Eyes and Chemotherapy
Hi All, After reading Polly PV post regarding her Eye issues, I have decided to write my issues! I started out with ET five years ago some 3 months later MF was diagnosed.. I am JAK2 with ASXL1 drivers etc, I started on HU and it brought Platelets down eventually. Three (3) years ago I started
Hi All, After reading Polly PV post regarding her Eye issues, I have decided to write my issues! I started out with ET five years ago some 3 months later MF was diagnosed.. I am JAK2 with ASXL1 drivers etc, I started on HU and it brought Platelets down eventually. Three (3) years ago I started
pontygirl
in
MPN Voice
1 year ago
Can this be considered castrate resistance?
Just wanting to know if we should change his steroid to
dexamethasone
in case this is development of resistance. Thanks so much!
Just wanting to know if we should change his steroid to
dexamethasone
in case this is development of resistance. Thanks so much!
Rodeoz15
in
Advanced Prostate Cancer
1 year ago
with drawl side effects or new side effects
Zytiga and
dexamethasone
-put him on xtandi- he now has been on 5 days and is very weak not sure if it's due to xtandi or because he is off Zytiga and steroid?
Zytiga and
dexamethasone
-put him on xtandi- he now has been on 5 days and is very weak not sure if it's due to xtandi or because he is off Zytiga and steroid?
Chris52981
in
Advanced Prostate Cancer
2 years ago
Thyroid or Pituitary Problem?
-6.8) Thyrogllobulin antibody 12 (<155), Thyroid Peroxidase <9 (<34) Fem Test: LH 7.3 (14-95.6) FSH 5.48 (4.7-21.5) Oestradiol 279 (222-1959) Testosterone 2.2 (0.29-1.67) Prolactin 430 (102-496) Adrenal: SHBG 25 (32.4-128) DHEA 1.9 (2.68-9.23) Cortisol 333 (133-537) 24hr Urine Cortisol 50 (<165),
Dexamethasone
-6.8) Thyrogllobulin antibody 12 (<155), Thyroid Peroxidase <9 (<34) Fem Test: LH 7.3 (14-95.6) FSH 5.48 (4.7-21.5) Oestradiol 279 (222-1959) Testosterone 2.2 (0.29-1.67) Prolactin 430 (102-496) Adrenal: SHBG 25 (32.4-128) DHEA 1.9 (2.68-9.23) Cortisol 333 (133-537) 24hr Urine Cortisol 50 (<165),
Dexamethasone
Amy_O
in
Thyroid UK
1 year ago
Prednislone and Anxiety
I've been reducing from 20mg pred since November 2022, currently on 11mg. Since Christmas I have had episodes of extreme anxiety, depression, mood swings and tearfulness. My Rheumy this morning suggested swapping to Betamethasone which does not cross the blood/brain barrier. However, when I researched
I've been reducing from 20mg pred since November 2022, currently on 11mg. Since Christmas I have had episodes of extreme anxiety, depression, mood swings and tearfulness. My Rheumy this morning suggested swapping to Betamethasone which does not cross the blood/brain barrier. However, when I researched
FleetRose
in
PMRGCAuk
1 year ago
Doxazosin and what’s next
I have had 2 strokes, one while undergoing chemotherapy, (ovarian cancer, hysterectomy and chemo due to cyst burst) which had to be stopped after 2 sessions due to reactions from Pachtaxel, and
Dexamethasone
(steroids). Was recovering well when woke up with limited movement on right.
I have had 2 strokes, one while undergoing chemotherapy, (ovarian cancer, hysterectomy and chemo due to cyst burst) which had to be stopped after 2 sessions due to reactions from Pachtaxel, and
Dexamethasone
(steroids). Was recovering well when woke up with limited movement on right.
Quilting4me
in
High Blood Pressure Support
1 year ago
ThIrd infusion of JANX007
If BP starts to drop,take 10 mg of
dexamethasone
. So far 14 hours later,I have not had any symptoms. The way the MO explained it the steriods keeps the drug from fully doing its job so he stated we was going to take the reins off and let it run.
If BP starts to drop,take 10 mg of
dexamethasone
. So far 14 hours later,I have not had any symptoms. The way the MO explained it the steriods keeps the drug from fully doing its job so he stated we was going to take the reins off and let it run.
ehoneycutt29
in
Advanced Prostate Cancer
2 years ago
intralipid infusion - what dosage did you have?
I will ask my clinic but trying to figure out whether it is a generic dose like the Prednisolone 25mg/
Dexamethasone
0.5mg or is it individualises dosage of intralipids? thank you so much for sharing!
I will ask my clinic but trying to figure out whether it is a generic dose like the Prednisolone 25mg/
Dexamethasone
0.5mg or is it individualises dosage of intralipids? thank you so much for sharing!
K8dferXdder
in
Fertility Network UK
2 years ago
zytiga, dexamethasone and weight gain/moonface
My husband, Mike, seems to be doing great cancer-wise sine switching from zytiga/prednisone to zytiga/
dexamethasone
(.5) Psa down to <.01and scans appearing clear. He switched in April. However he has been gaining weight 20lbs high on his abdomen and his face has become quite puffy.
My husband, Mike, seems to be doing great cancer-wise sine switching from zytiga/prednisone to zytiga/
dexamethasone
(.5) Psa down to <.01and scans appearing clear. He switched in April. However he has been gaining weight 20lbs high on his abdomen and his face has become quite puffy.
longleaf
in
Advanced Prostate Cancer
2 years ago
Egg collection straight after FET - can you do this?
It involves me taking a small dose of a steroid,
dexamethasone
at the start of the cycle. I asked how that would interact with the other steroid - prednisone - I am weaning off of from the previous cycle. She paused and said actually, better off to wait a month.
It involves me taking a small dose of a steroid,
dexamethasone
at the start of the cycle. I asked how that would interact with the other steroid - prednisone - I am weaning off of from the previous cycle. She paused and said actually, better off to wait a month.
AdviceforJane
in
Fertility Network UK
2 years ago
steriods
anyone who’s treatment stop Been put on
dexamethasone
if so what dose And any side effects x
anyone who’s treatment stop Been put on
dexamethasone
if so what dose And any side effects x
Red58
in
Lung Cancer Support
2 years ago
psa up again how much can it range
on Zytiga and
dexamethasone
and lupron - my psa was like .34, .47, now.60 I’m Not sure when to Worry and what else I can try after this -
on Zytiga and
dexamethasone
and lupron - my psa was like .34, .47, now.60 I’m Not sure when to Worry and what else I can try after this -
Chris52981
in
Advanced Prostate Cancer
2 years ago
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