Can this be considered castrate resistance?

[Rodeoz15]

Hi all

My father was diagnosed with PCa last year in April with an initial PSA of 500. Through ADT his PSA dropped to 0.4 in 16 months. In the last 3 months his PSA has increased as follows:

September: 0.42

October: 0.45

November: 0.53

Is this considered three consecutive increases which people talk about or is this fluctuation normal? He has an intact prostate and hasn't undergone radiation either.

Just wanting to know if we should change his steroid to dexamethasone in case this is development of resistance.

Thanks so much!

[Tall_Allen]

Castration resistance can be a slow process. You can try switching to dexamethasone to get longer use out of Zytiga.

[Soumen79 in reply to Tall_Allen]

Hi TA, just wondering, this use of dexamethasone is supported by any RCT?

[Tall_Allen in reply to Soumen79]

bjui-journals.onlinelibrary...

[Soumen79 in reply to Tall_Allen]

Excellent, thank you TA.