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My Basic "Understanding" of PD Has Been Wrong
We all know that the causes of Parkinson's Disease are complicated, varied, and not completely known. Yet, I have always understood that, at its core, PD is the gradual and unpreventable death of dopinergic neurons caused by the misfolding of a protein and the accumulation and aggregation of alpha synuclein
We all know that the causes of Parkinson's Disease are complicated, varied, and not completely known. Yet, I have always understood that, at its core, PD is the gradual and unpreventable death of dopinergic neurons caused by the misfolding of a protein and the accumulation and aggregation of alpha synuclein
jimcaster
in
Cure Parkinson's
3 years ago
Adjusting to my new meds
My psychiatrist told me to stop Zoloft gradually and put me on Seroxat 20 mg with gradual increasing doses and kept me on Venlax 75 and
Depakine
500 mg chrono. However, I feel like withdrawal symptoms either from Zoloft or from the new medicine.
My psychiatrist told me to stop Zoloft gradually and put me on Seroxat 20 mg with gradual increasing doses and kept me on Venlax 75 and
Depakine
500 mg chrono. However, I feel like withdrawal symptoms either from Zoloft or from the new medicine.
Luna-blade
in
My OCD Community
4 years ago
Dopamine Detox
I did a dopamine detox a month ago for 15 days. No music, fapping, movies, tv series, junk food. It helped me a lot and I got used to it. I'm doing one again. And it hurts cause I've seen so many TV series and all in the past few days that I am feeling restless not doing it. It hurts but I'm going to
I did a dopamine detox a month ago for 15 days. No music, fapping, movies, tv series, junk food. It helped me a lot and I got used to it. I'm doing one again. And it hurts cause I've seen so many TV series and all in the past few days that I am feeling restless not doing it. It hurts but I'm going to
oldtimer159
in
Anxiety and Depression Support
3 years ago
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Damn Rls I hate you
I've had I've had restless leg syndrome since I was a little girl unless the nightly torture for me for years it comes and goes but most of the time it's on and as I've gotten older it seems to have gotten worse I'm on mirapex can I take two .25 mg 2 hours before bed but most nights I seem to have to
I've had I've had restless leg syndrome since I was a little girl unless the nightly torture for me for years it comes and goes but most of the time it's on and as I've gotten older it seems to have gotten worse I'm on mirapex can I take two .25 mg 2 hours before bed but most nights I seem to have to
brickscrawling
in
Restless Legs Syndrome
3 years ago
Protocol supports hwp.
I was asked to share my hwp Protocol - I share only because it is supporting him and he is not on any Parkinson medications. Daily Brain (30 day supplement) breakfast prepackaged - inc. grapeseed extract, phosphatidylserine, curcumin, omega-3 EPA/DHA, 10 billion Probiotic. Check out nationalnutrition.ca
I was asked to share my hwp Protocol - I share only because it is supporting him and he is not on any Parkinson medications. Daily Brain (30 day supplement) breakfast prepackaged - inc. grapeseed extract, phosphatidylserine, curcumin, omega-3 EPA/DHA, 10 billion Probiotic. Check out nationalnutrition.ca
Spencer53
in
Cure Parkinson's
3 years ago
first trial in the United States to study pluripotent stem cell-derived dopaminergic neurons in patients with Parkinsons
This is a big step for the stem cell field – to finally test a truly “off-the-shelf” dopamine neuron product in human PD patients https://bluerocktx.com/news/bluerock-therapeutics-in-collaboration-with-memorial-sloan-kettering-cancer-center-receives-ind-clearance-for-da01-in-parkinsons-disease/
This is a big step for the stem cell field – to finally test a truly “off-the-shelf” dopamine neuron product in human PD patients https://bluerocktx.com/news/bluerock-therapeutics-in-collaboration-with-memorial-sloan-kettering-cancer-center-receives-ind-clearance-for-da01-in-parkinsons-disease/
Farooqji
in
Cure Parkinson's
3 years ago
Fisetin
Fisetin has been covered in other posts but there may be something new here. Fisetin is a polyphenol found in foods like strawberries. Fisetin shows promise as a senolytic, or compound that removes harmful senescent cells. Dr. Terry Burns is a neurosurgeon who sees promise for such compounds for neuroregeneration
Fisetin has been covered in other posts but there may be something new here. Fisetin is a polyphenol found in foods like strawberries. Fisetin shows promise as a senolytic, or compound that removes harmful senescent cells. Dr. Terry Burns is a neurosurgeon who sees promise for such compounds for neuroregeneration
Zardoz
in
Cure Parkinson's
3 years ago
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
Niacin PD patients are found to have significantly decreased niacin levels compared to age-matched healthy controls [52]. This has been attributed to both the disease itself and the medication used to attenuate motor symptoms [58]. Sinemet, the most commonly used PD medication, includes carbidopa, which
Niacin PD patients are found to have significantly decreased niacin levels compared to age-matched healthy controls [52]. This has been attributed to both the disease itself and the medication used to attenuate motor symptoms [58]. Sinemet, the most commonly used PD medication, includes carbidopa, which
Farooqji
in
Cure Parkinson's
3 years ago
Stem Cell Transplantation at Mass General
I have posted about this particular stem cell transplantation at least twice before. I understand that it was a "pay for play" situation. I understand that it is an "N of 1" situation. I understand that "placebo effect" could be a factor. I understand that much broader studies may be necessary. With
I have posted about this particular stem cell transplantation at least twice before. I understand that it was a "pay for play" situation. I understand that it is an "N of 1" situation. I understand that "placebo effect" could be a factor. I understand that much broader studies may be necessary. With
jimcaster
in
Cure Parkinson's
3 years ago
ATREMO PLUS to raise dopamine ?
Has anybody tried atremo plus ? Reviews are good. Can't put the order through. Not sure why. They are on the phone but don't return calls to Australia. I'm keen to try this favs bean product. Thanks all.
Has anybody tried atremo plus ? Reviews are good. Can't put the order through. Not sure why. They are on the phone but don't return calls to Australia. I'm keen to try this favs bean product. Thanks all.
Vegegardner
in
Cure Parkinson's
3 years ago
Temgesic is working!
I have been on the neupro patch for a number of years with great results. However, I know it’s only time before augmentation kicks in. So after reading previous posts about Temgesic I discussed it with my GP. She agreed to prescribe it and I have been great for past 12 days. I’m glad to be off the Dopamine
I have been on the neupro patch for a number of years with great results. However, I know it’s only time before augmentation kicks in. So after reading previous posts about Temgesic I discussed it with my GP. She agreed to prescribe it and I have been great for past 12 days. I’m glad to be off the Dopamine
Poppip
in
Restless Legs Syndrome
4 years ago
Thankful for this forum
Hello Everyone. I found this forum about a week and a half ago. I did a google search on side effects for Gabapentin and thankfully stumbled across this in the search results. I haven't posted much but have looked through a few of the topics relevant to me and they've been very helpful. I've had RLS
Hello Everyone. I found this forum about a week and a half ago. I did a google search on side effects for Gabapentin and thankfully stumbled across this in the search results. I haven't posted much but have looked through a few of the topics relevant to me and they've been very helpful. I've had RLS
BigAdam
in
Restless Legs Syndrome
4 years ago
How do we satisfy our dopamine crave? Why do I need to fulfill that emotion?
What can we do to overcome that overwhelming sensation of thrill?
What can we do to overcome that overwhelming sensation of thrill?
Hidden
in
CHADD's Adult ADHD Support
4 years ago
Avoid levodopa phobia
I was reading Simon’s latest article about the PD drug development pipeline, which is a good read anyway - https://scienceofparkinsons.com/2020/12/02/drug-pipeline/ - and watched this video from Dr Kelly Mills of Johns Hopkins University about disease-modifying vs symptomatic therapy - https://youtu.be
I was reading Simon’s latest article about the PD drug development pipeline, which is a good read anyway - https://scienceofparkinsons.com/2020/12/02/drug-pipeline/ - and watched this video from Dr Kelly Mills of Johns Hopkins University about disease-modifying vs symptomatic therapy - https://youtu.be
Cagey84
in
Cure Parkinson's
4 years ago
Secondary RLS, Nexplanon, antidepressants, and iron?
hi, i have another long winded post! :) the questions are also repeated in the post! questions (so you don’t have to read this whole thing if you don’t want ;)): -if my RLS is secondary, would i benefit from using a dopamine agonist? and if i were to take an SSRI or something like buspar, would i be
hi, i have another long winded post! :) the questions are also repeated in the post! questions (so you don’t have to read this whole thing if you don’t want ;)): -if my RLS is secondary, would i benefit from using a dopamine agonist? and if i were to take an SSRI or something like buspar, would i be
mmjxc
in
Restless Legs Syndrome
4 years ago
"Alternative" treatments are not harmless when whey cost you quality of life
It's common to read on this forum that alternatives are harmless and have no side effects. But what about when a PWP eschews traditional treatment in favour of an alternative, and their quality of life suffers as a result? All we have is the immediate future. Today. Probably tomorrow. Maybe the day
It's common to read on this forum that alternatives are harmless and have no side effects. But what about when a PWP eschews traditional treatment in favour of an alternative, and their quality of life suffers as a result? All we have is the immediate future. Today. Probably tomorrow. Maybe the day
Hidden
in
Cure Parkinson's
4 years ago
Confession
Some of you have reached out to me and have asked after hubby so I thought I would start a new post. Thank you for asking and for your concern. It’s been about 5 months since I last checked in. To be honest I needed an escape from seeing how many newbies have had a need for this site, how many people
Some of you have reached out to me and have asked after hubby so I thought I would start a new post. Thank you for asking and for your concern. It’s been about 5 months since I last checked in. To be honest I needed an escape from seeing how many newbies have had a need for this site, how many people
SewBears
in
PSP Association
4 years ago
Adult ADHD late diagnosis and onset of peri/ menopause hell.( tips, experience or wisdom??)
So I’m 53 and joined this because I feel more insane than ever. I was diagnosed having ADHD when I was 45 or 46...( I have zero sence of time and linear anything at moment) Any way ,?pist diagnosis my doctor urged me try adderal in conjunction with other psychotropic medications. This was a colleague
So I’m 53 and joined this because I feel more insane than ever. I was diagnosed having ADHD when I was 45 or 46...( I have zero sence of time and linear anything at moment) Any way ,?pist diagnosis my doctor urged me try adderal in conjunction with other psychotropic medications. This was a colleague
JenInk
in
CHADD's Adult ADHD Support
4 years ago
Pure OCD
Aside from Zoloft,
depakine
and venlax, I’m on lexotanil as I relapsed again after putting in effort on my phd but more effort in taking care of my demanding dad. I fear everything. I can’t get into terms with reality as my education at home was brutal and severe.
Aside from Zoloft,
depakine
and venlax, I’m on lexotanil as I relapsed again after putting in effort on my phd but more effort in taking care of my demanding dad. I fear everything. I can’t get into terms with reality as my education at home was brutal and severe.
Luna-blade
in
My OCD Community
4 years ago
Confused and down.
I find it really hard to put into words how I feel. I've never experienced such low mood before. My brain feels like fog. There's like a little circle in the middle of brain that can focus, and the rest is just a blurry surrounding. I used to gamble while I had mild depression , because I craved that
I find it really hard to put into words how I feel. I've never experienced such low mood before. My brain feels like fog. There's like a little circle in the middle of brain that can focus, and the rest is just a blurry surrounding. I used to gamble while I had mild depression , because I craved that
Dalegee
in
Anxiety and Depression Support
4 years ago
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