I have posted about this particular stem cell transplantation at least twice before. I understand that it was a "pay for play" situation. I understand that it is an "N of 1" situation. I understand that "placebo effect" could be a factor. I understand that much broader studies may be necessary.
With all of those caveats, I'm sharing this again for 3 reasons: (1) To provide us all with much needed optimism; (2) To express my frustration at the pace of progress; and (3) To ask about whether "sham" procedures are necessary or even ethical when it comes to surgical interventions.
I was diagnosed nearly three years ago and have been enthusiastic about stem cell treatments that entire time. The pace is painfully slow. I would consider trying to volunteer for a stem cell trial, but the possibility of being part of the placebo group ("sham group") both scares and annoys me. I know PD progresses slowly so validation of test results takes time, but can't we do better than this?
That's enough ranting. For those of you wanting dose of optimism, here you go:
"We've made a significant step in personalizing the therapy, overcoming ethical issues and eliminating the need for immunosuppression," says Dr. Schweitzer. "Our work is grounds for cautious optimism, it's a new approach to an old problem."
Two years after the surgeries, the patient has had no adverse events and reports improvements in daily function. Standardized examinations of motor functions also showed stabilization or improvement, and a PET scan suggested that the progenitor cells were making dopamine at the transplantation sites.
"This particular patient is an outdoor sports person and had to give up many of his favorite activities as the disease progressed," says Dr. Schweitzer. "It has been gratifying to see the patient regain ability and confidence in physical activities such as skiing and swimming that he has most appreciated throughout his life.
Stem Cell Therapy for Parkinsons
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Stem Cells for PD - To wait or not to wait?
