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Question - how many different varieties of antibodies can B-cells make? Hint - it's hypermutation (IGHV mutation) that makes it possible
Answer, 1 quintillion or 1,000,000,000,000,000,000 or 10^18 according to[i] a team led by Drs. Bryan Briney and Dennis R. Burton at Scripps Research examined antibody-producing B cells isolated from blood samples of 10 people between the ages of 18 and 30. ... Additional studies are needed to more accurately
Answer, 1 quintillion or 1,000,000,000,000,000,000 or 10^18 according to[i] a team led by Drs. Bryan Briney and Dennis R. Burton at Scripps Research examined antibody-producing B cells isolated from blood samples of 10 people between the ages of 18 and 30. ... Additional studies are needed to more accurately
AussieNeil
Administrator
in
CLL Support
5 years ago
Chemo-Free Treatment Best Option for CLL Patients Under 70
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus rituximab (Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine,
cyclophosphamide
, and rituximab, known as FCR.
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus rituximab (Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine,
cyclophosphamide
, and rituximab, known as FCR.
GlennSabin
in
CLL Support
5 years ago
Chemo-Free Treatment Best Option for CLL Patients Under 70
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus rituximab (Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine,
cyclophosphamide
, and rituximab, known as FCR.
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus rituximab (Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine,
cyclophosphamide
, and rituximab, known as FCR.
GlennSabin
in
CLL America Support
5 years ago
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Treatments for C3G
These drugs include: o Glucocorticoids (corticosteroids, steroids) o Rituximab o
Cyclophosphamide
o Mycophenolate mofetil (MMF) o Tacrolimus o Sirolimus o Azathioprine
• Plasma exchange (plasmapheresis):
Plasma
These drugs include: o Glucocorticoids (corticosteroids, steroids) o Rituximab o
Cyclophosphamide
o Mycophenolate mofetil (MMF) o Tacrolimus o Sirolimus o Azathioprine
• Plasma exchange (plasmapheresis):
Plasma
DavidF_NKF
Administrator
in
C3 Glomerulopathy
5 years ago
Chemo Finished
At long last my final cycle of FCR has been completed, and looking back on the last six months it has been a pretty eventful journey, but I will say to all of you that are about to begin FCR treatment and those already mid treatment I do believe it has been a journey worth taking. The low points passing
At long last my final cycle of FCR has been completed, and looking back on the last six months it has been a pretty eventful journey, but I will say to all of you that are about to begin FCR treatment and those already mid treatment I do believe it has been a journey worth taking. The low points passing
dandelup
in
CLL Support
5 years ago
HRT for early onset menopause caused by meds. I have SLE & Lupus Nephritis. Is this a recipe for flares, flares, flares or ???
Also discovered that I am allergic to Mycophenolate so... ...two cycles of 3 months each of
cyclophosphamide
, 2 yrs on Tacrolimus and 5 months of methotrexate, Iand finally I am sort of in remission. I remain on Plaquinel and 5mg of Pred, with occasional pulse doses of methylprednisone.
Also discovered that I am allergic to Mycophenolate so... ...two cycles of 3 months each of
cyclophosphamide
, 2 yrs on Tacrolimus and 5 months of methotrexate, Iand finally I am sort of in remission. I remain on Plaquinel and 5mg of Pred, with occasional pulse doses of methylprednisone.
lil_darling
in
LUpus Patients Understanding and Support
5 years ago
Breaking news form ASH conference: looks like Ibrutinib May be better than FCR for some patients
Standard Fludarabine,
Cyclophosphamide
, and Rituximab (FCR) Chemoimmunotherapy in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL) | #leusm ash.confex.com/ash/2018/webpr…
Standard Fludarabine,
Cyclophosphamide
, and Rituximab (FCR) Chemoimmunotherapy in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL) | #leusm ash.confex.com/ash/2018/webpr…
Newchallnge
in
CLL Support
5 years ago
CLL chemo more than 10 days fever!
Hello! I have CLL and had my first FCR chemo except not Rituximab but Ofatumumab. Everything went well but since 10 days I have extreme high fever 39,9-40 degrees and itchy everywhere on my body and under my feet and hands. The meds for itchy help but i feel its not gone but the fever is still there
Hello! I have CLL and had my first FCR chemo except not Rituximab but Ofatumumab. Everything went well but since 10 days I have extreme high fever 39,9-40 degrees and itchy everywhere on my body and under my feet and hands. The meds for itchy help but i feel its not gone but the fever is still there
Eriksan2
in
CLL Support
5 years ago
Kimsome
Hello all of my CLL friends!! Happy New Year as well!! So, I was diagnosed with CLL in 2010 when I was 45 year old woman. Went through aggressive chemo, FCR. In my case the sickness now supposedly in remission but continued to make me critically ill even when it was over. If fact, I was in and out
Hello all of my CLL friends!! Happy New Year as well!! So, I was diagnosed with CLL in 2010 when I was 45 year old woman. Went through aggressive chemo, FCR. In my case the sickness now supposedly in remission but continued to make me critically ill even when it was over. If fact, I was in and out
Kimsome
in
CLL Support
5 years ago
Last cycle of FCR next week
I am on the Flair trial am now approaching my last lot of FCR. When signing up to Flair given the choice FCR would have been my last choice of treatment, but on reflection although it has been tough, I am glad it’s the arm I was given. My haematologist told me that it is still regarded as the gold standard
I am on the Flair trial am now approaching my last lot of FCR. When signing up to Flair given the choice FCR would have been my last choice of treatment, but on reflection although it has been tough, I am glad it’s the arm I was given. My haematologist told me that it is still regarded as the gold standard
dandelup
in
CLL Support
5 years ago
Benlysta Maintenance Does Not Change Kidney Function of Lupus Nephritis Patients, Phase 2 Trial Shows
All participants received 1,000 mg of intravenous (into the bloodstream) Rituxan, 750 mg of the immunosuppressive therapy
cyclophosphamide
, and 200 mg of the corticosteroid methylprednisolone at the start of the study and the second week, and an initial daily prednisone dose of 40 mg, which was progressively
All participants received 1,000 mg of intravenous (into the bloodstream) Rituxan, 750 mg of the immunosuppressive therapy
cyclophosphamide
, and 200 mg of the corticosteroid methylprednisolone at the start of the study and the second week, and an initial daily prednisone dose of 40 mg, which was progressively
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
5 years ago
ASH 2018: ECOG trial shows superiority of Ibrutinib and rituximab over FCR
Hi friends, The early buzz at ASH 2018 was rightly about the ECOG trial that was presented on the last day as a late breaking abstract. In my interview at the opening of the conference, Dr. Stilgenbauer discusses the practice changing significance of this study that proved that ibrutinib and rituximab
Hi friends, The early buzz at ASH 2018 was rightly about the ECOG trial that was presented on the last day as a late breaking abstract. In my interview at the opening of the conference, Dr. Stilgenbauer discusses the practice changing significance of this study that proved that ibrutinib and rituximab
bkoffman
CLL CURE Hero
in
CLL Support
5 years ago
FCR or BR proposed for second round of treatment in London
Diagnosed end of 2013. FLAIR trail Nov 2015 – June 2016 stopped due to severe muscle pain. (See previous posts) Now need more treatment. Moved up partly because I also need a hip replacement and they can’t do it with my low immunity. So I am now being offered FCR or BR. A year or so ago I was told there
Diagnosed end of 2013. FLAIR trail Nov 2015 – June 2016 stopped due to severe muscle pain. (See previous posts) Now need more treatment. Moved up partly because I also need a hip replacement and they can’t do it with my low immunity. So I am now being offered FCR or BR. A year or so ago I was told there
romarin
in
CLL Support
5 years ago
Question about ibrutinib
Hi all, I posted here once, about 6 months ago. I am a 34 yeard old dutch male from Amsterdam, and i have CLL with unfavorable prognosis. I had FCR, and some other meds over the course of 11 years. Right now i am on Ibrutinib and am being threated by Prof. Dr. Kater at the Amsterdam hostpital 'AMC
Hi all, I posted here once, about 6 months ago. I am a 34 yeard old dutch male from Amsterdam, and i have CLL with unfavorable prognosis. I had FCR, and some other meds over the course of 11 years. Right now i am on Ibrutinib and am being threated by Prof. Dr. Kater at the Amsterdam hostpital 'AMC
JanAmsterdam
in
CLL Support
5 years ago
FCR, novel agents, advances in CLL treatment, what CLL patients can hope for in the future. Australian experts discuss advances at ASH2018
Great to hear of real change beginning to happen in CLL, we really do have a reason to be hopeful. Leukaemia Care have interviewed global experts at The American Society of Haematology conference (ASH) on video for you to share in this. https://youtu.be/vLleI7G-gfk https://youtu.be/lEz4GkRX3Q8 https
Great to hear of real change beginning to happen in CLL, we really do have a reason to be hopeful. Leukaemia Care have interviewed global experts at The American Society of Haematology conference (ASH) on video for you to share in this. https://youtu.be/vLleI7G-gfk https://youtu.be/lEz4GkRX3Q8 https
HAIRBEAR_UK
Administrator
in
Leukaemia CARE
5 years ago
FCR, novel agents, advances in CLL treatment, what CLL patients can hope for in the future. Australian experts discuss advances at ASH2018
Great to hear of real change beginning to happen in CLL, we really do have a reason to be hopeful. Leukaemia Care have interviewed global experts at The American Society of Haematology conference (ASH) on video for you to share in this. https://youtu.be/vLleI7G-gfk https://youtu.be/lEz4GkRX3Q8 https
Great to hear of real change beginning to happen in CLL, we really do have a reason to be hopeful. Leukaemia Care have interviewed global experts at The American Society of Haematology conference (ASH) on video for you to share in this. https://youtu.be/vLleI7G-gfk https://youtu.be/lEz4GkRX3Q8 https
HAIRBEAR_UK
Administrator
in
CLL Support
5 years ago
My Dana-Farber Trial Update
Started Acalabrutinib in August and had a couple of headaches over the first week. Called my care team. Tylenol basically stopped the headaches. They never came back. Zero side effects from Obinutuzumab. Today, I completed my first dose of Venetoclax at 400 mg after titrating up for a month. Maybe a
Started Acalabrutinib in August and had a couple of headaches over the first week. Called my care team. Tylenol basically stopped the headaches. They never came back. Zero side effects from Obinutuzumab. Today, I completed my first dose of Venetoclax at 400 mg after titrating up for a month. Maybe a
Lily_Pad_Master
in
CLL Support
5 years ago
Please ask your friends and famly to give blood this holiday season
RED CROSS https://www.redcrossblood.org/local-homepage/news/article/red-cross-urges-blood-donation-as-one-last-gift-to-give-this-holiday-season.html 💉 NHS https://www.blood.co.uk 💉 Canada Blood Services https://blood.ca/en 💉 Australian Blood Services https://www.donateblood.com.au
PLEASE REMEMBER
RED CROSS https://www.redcrossblood.org/local-homepage/news/article/red-cross-urges-blood-donation-as-one-last-gift-to-give-this-holiday-season.html 💉 NHS https://www.blood.co.uk 💉 Canada Blood Services https://blood.ca/en 💉 Australian Blood Services https://www.donateblood.com.au
PLEASE REMEMBER
Cllcanada
Top Poster CURE Hero
in
CLL Support
5 years ago
90 days on Ibrutinib
Today marks the 90th day I have been on Ibrutinib. I feel blessed that I've only had a mild reaction and then only in the first month. I still suffer from Infections because of low immunity. This has been demonstrated in the last week with a sickness and diahorrea bug which lasted a week for me but 24
Today marks the 90th day I have been on Ibrutinib. I feel blessed that I've only had a mild reaction and then only in the first month. I still suffer from Infections because of low immunity. This has been demonstrated in the last week with a sickness and diahorrea bug which lasted a week for me but 24
Mick491
in
CLL Support
5 years ago
Starting chemotherapy (Cyclophosphamide)
Hi everyone, I hope you are all having a good week :) I will be starting my first round of chemo next week with
cyclophosphamide
as my scleroderma is affecting my lungs. I wondered if anyone has been through it or has any advice/tips?
Hi everyone, I hope you are all having a good week :) I will be starting my first round of chemo next week with
cyclophosphamide
as my scleroderma is affecting my lungs. I wondered if anyone has been through it or has any advice/tips?
Maryam_a
in
Scleroderma & Raynaud's UK (SRUK)
6 years ago
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