Experiences with

Cyclophosphamide

My Consultant is considering adding a course of cyclophosphamide to my treatment plan.

VJHEMONC video - Graham Collins, MA, MBBS, MRCP, FRCPath, DPhil, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, discusses data from the Phase III POLARIX study (NCT03274492) which evaluated polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisone https://www.vjhemonc.com

I guess I am posting to see if anyone else has suffered with the swelling, which I've seen for around 6 months now, or any effects of cyclophosphamide. They're hoping to move me onto mycophenolate or rituximab once I'm done with the chemotherapy.

8 years from 3c diagnosis and 2 operations and lots of chemo treatments later, I’m now on daily cyclophosphamide. Good news at hospital today. Markers have gone down again and the liver lesion appears to have disappeared altogether.

And if you are on Rituximab or Cyclophosphamide seek advice from your consultant re timing. Here is the Scottish Spring Booster info page. https://www.nhsinform.scot/covid-19-vaccine/the-vaccines/coronavirus-covid-19-booster-vaccination/

Hello, reporting after the first 8 weeks of taking Cyclophosphamide 100mg every day with Letrazole 50mg ( my choice to continue this). I am ER+HER-. liver and bone mets. enlarged lymph nodes in neck. Exhausted endochrine options and now on oral chemo options.

As an alternative ( the only one offered) is Cyclophosphamide 500mg 6 x 2 weekly infusions. He is about to send me informayion on the drug and then I need to decide. I don't think I have any choice.

(I have been on the euro-lupus regime since Feb, with 3x IV methylpred and 6x infusions of cyclophosphamide. I've also been started on tacrolimus, I've taken hydroxychloroquine for over a year, and the plan after cyclo is to also start mycophenolate).

The latest plan is to have a course of IV steroids and start IV Cyclophosphamide in the rheumatology day unit in Bath. I just wondered if there is anyone else out there with CNS lupus or anyone who has had biologic infusions that would be happy to share their experiences with me.

I've been on bosenton, tadalafil, and injections of cyclophosphamide 500 mg and mythhylprednisolone 500 mg every one month. My symptoms are not under control, despite using medications like these. I've tried everything to control the symptoms, but they aren't going away.

MRI (arranged through my local hospital where there is a 6mth waiting list for MRI s some how on his advice it was organised in 2 weeks) The last time I saw him he said I had a Demyelinating syndrome caused be an underlying vascular disorder I had demyelination from C2 to C6 and it was treated with cyclophosphamide

I’ve just taken my first tablet and was wondering if there is anyone else on this chemo. I would really like to know what to expect. Gilly x

Hello to All, My husband had an appointment with his neurologist today. The latest MRI indicates he still has Encephalitis. With the latest cocktail of meds, (prednisone, mycophenolate and Rituxan) his doctor thought the encephalitis would show improvement or be totally gone by now. His doctor

I'm taking injections of mythylprednisolone and cyclophosphamide, but they don't seem to be working. My doctor recommends that I start using biological medications, specifically ritixumab or illoprost infusion. Is anyone on illoprost infusion? Also, what is the price?

Anyone on here had any experience with oral Cyclophosphamide please? Gilly x

NCT04768608 Study 5: Title: A Study of CART-PSMA-TGFβRDN in Patients With Metastatic Castration Resistant Prostate Cancer Status: Active, not recruiting Study Results: No Results Available Conditions: Metastatic Castration-resistant Prostate Cancer Interventions: Biological: CART-PSMA-TGFβRDN|Drug: Cyclophosphamide

His concern is that he had both initial Covid vaccines whilst undergoing cyclophosphamide treatment snd is terrified he has no immunity to Covid.

PH Dr mentioned Cyclophosphamide. Rheumy keen for her to start on another biologic as will be better for her PH but haven't come up with any offerings. Wondering if any one had experience of been given another biologic or other treatment following reaction to Rituximab?

So traditionally, with CAR T cells in leukemia and lymphoma, they give cyclophosphamide and fludarabine. We weren't sure whether that would be necessary when we were translating this to solid tumors because the solid tumor is not in the space where leukemia and lymphoma reside.

There are similar drugs chemically to Thalidomide that patients who have to stop it can be switched to instead, but I then demanded the Cyclophosphamide chemotherapy infusions which the consultant had ruled out multiple times for various reasons (his concerns about very young me’s fertility + my already