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Protein discovery could help solve prostate cancer drug resistance Date:January 22, 2024 Source:Washington State University
Wu said this type of
combination
therapy
could also potentially be used for other cancers that are currently being treated with docetaxel, such as breast and lung cancer. It may also be possible to use the same combination strategy with other similar chemotherapy drugs.
Wu said this type of
combination
therapy
could also potentially be used for other cancers that are currently being treated with docetaxel, such as breast and lung cancer. It may also be possible to use the same combination strategy with other similar chemotherapy drugs.
MsHope
in
Advanced Prostate Cancer
19 days ago
Spine metastasis
Is this something they would get a PSMA TEST for to confirm and also would he just receive ADT with radiation to primary site or are there also new
combination
therapy
we should look into. Thanks in advance to everyone willing to share their well earned wisdom .
Is this something they would get a PSMA TEST for to confirm and also would he just receive ADT with radiation to primary site or are there also new
combination
therapy
we should look into. Thanks in advance to everyone willing to share their well earned wisdom .
Telegraph2022
in
Advanced Prostate Cancer
4 months ago
NHS Endo - South East - Pro T3 - Three referral choices...
Hi, I went T3 only 3 weeks ago after trying
combination
therapy
for 6 months. At around the same I had my local surgery test for blood FBC, blood sugar, cholesterol, calcium folate, B12 Iron etc. This was just to check for my self that I wasn't encountering any other issues.
Hi, I went T3 only 3 weeks ago after trying
combination
therapy
for 6 months. At around the same I had my local surgery test for blood FBC, blood sugar, cholesterol, calcium folate, B12 Iron etc. This was just to check for my self that I wasn't encountering any other issues.
joey82
in
Thyroid UK
4 months ago
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coming off rotigotine patches
Read the latest Mayo algorithm, assume the next option would be to gabapentin or
combination
therapy
. Looking to book an appointment with Dr Jose Thomas to discuss this in Jan if possible (privately) as waiting for an my neurologist appointment for over 4 months now and still haven’t heard back.
Read the latest Mayo algorithm, assume the next option would be to gabapentin or
combination
therapy
. Looking to book an appointment with Dr Jose Thomas to discuss this in Jan if possible (privately) as waiting for an my neurologist appointment for over 4 months now and still haven’t heard back.
Artifcial
in
Restless Legs Syndrome
5 months ago
Why should ft4 be at a certain percentage through reference range (mid to upper) when on T4/T3 combination therapy when T4 is inactive?
As per the subject title, if ft4 is inactive, then why do some people on T4/T3 therapy only feel good if their ft4 level is at the mid/upper level despite the fact their ft3 (active form) may be at a optimal level? Or if they are not feeling well, why are they advised to increase their Levo dosage if
As per the subject title, if ft4 is inactive, then why do some people on T4/T3 therapy only feel good if their ft4 level is at the mid/upper level despite the fact their ft3 (active form) may be at a optimal level? Or if they are not feeling well, why are they advised to increase their Levo dosage if
RIGBY1978
in
Thyroid UK
3 months ago
Ongoing battle to stay on T3
While I was in the appointment, the endo showed me a letter from the GP surgery saying they want me to be on
combination
therapy
back on levo with a small amount of T3. I did not receive a copy of this letter buttold the endo I was appalled and want a copy under a SAR (subject access request).
While I was in the appointment, the endo showed me a letter from the GP surgery saying they want me to be on
combination
therapy
back on levo with a small amount of T3. I did not receive a copy of this letter buttold the endo I was appalled and want a copy under a SAR (subject access request).
Freewoman1997
in
Thyroid UK
2 months ago
Vitamin and mineral deficiencies/Thyroid dysfunction.. Chicken or Egg?
I think I either need an increase of T4 or addition of T3, either as NDT or
combination
therapy
but I wonder if the doctors would just say I need to get my vitamins and minerals up before we try that. Or, conversely, if I tried T3 would that improve my vitamin/mineral levels?
I think I either need an increase of T4 or addition of T3, either as NDT or
combination
therapy
but I wonder if the doctors would just say I need to get my vitamins and minerals up before we try that. Or, conversely, if I tried T3 would that improve my vitamin/mineral levels?
doingitfordad
in
Thyroid UK
7 months ago
How you can help make ibrutinib plus venetoclax fixed duration therapy a reality for Australians with previously untreated CLL
In March 2024, PBAC will again consider a submission to recommend a 15-month
combination
therapy
of ibrutinib plus venetoclax for those with untreated CLL.
In March 2024, PBAC will again consider a submission to recommend a 15-month
combination
therapy
of ibrutinib plus venetoclax for those with untreated CLL.
CLLerinOz
Volunteer
in
CLL Support
5 months ago
t3 Monotherapy
Luckily the US doctor is happy to write a t3 prescription which is how I have been able to continue on
combination
therapy
, without it I would truly be a mess or worse. This is not a permanent solution and an extremely expensive way to fill a prescription.
Luckily the US doctor is happy to write a t3 prescription which is how I have been able to continue on
combination
therapy
, without it I would truly be a mess or worse. This is not a permanent solution and an extremely expensive way to fill a prescription.
Jimjamio
in
Thyroid UK
1 month ago
Studies comparing Levo mono vs Levo/Lio combo T4/T3 treatment
[/i]
It also clarifies:
[i]Published trials of
combination
therapy
have not targeted patients who have relatively low serum T3 values during monotherapy. In addition, the serum T3 values achieved during
combination
therapy
have not been a specific endpoint of these trials.
[/i]
It also clarifies:
[i]Published trials of
combination
therapy
have not targeted patients who have relatively low serum T3 values during monotherapy. In addition, the serum T3 values achieved during
combination
therapy
have not been a specific endpoint of these trials.
FallingInReverse
in
Thyroid UK
2 months ago
Update on Endo and WLAMS
[/i] [i]As previously stated, in patients on
combination
therapy
, if TSH is low or suppressed, free T4 or free T3 should be measured and it should be stated on the laboratory request that the patient is taking liothyronine.
[/i] [i]As previously stated, in patients on
combination
therapy
, if TSH is low or suppressed, free T4 or free T3 should be measured and it should be stated on the laboratory request that the patient is taking liothyronine.
serenfach
in
Thyroid UK
3 months ago
Doxycycline, small clinical trial
Doxycycline, Azithromycin and Vitamin C (DAV): A potent
combination
therapy
for targeting mitochondria and eradicating cancer stem cells (CSCs) 10.18632/aging.101905
Doxycycline, Azithromycin and Vitamin C (DAV): A potent
combination
therapy
for targeting mitochondria and eradicating cancer stem cells (CSCs) 10.18632/aging.101905
Purple-Bike
in
Advanced Prostate Cancer
7 months ago
Can anyone help
I would prefer to have a medical professional on-side with any treatments I might find myself needing - Im thinking here of possible
combination
therapy
. I fully understand the commissioning issues around the prescribing go t3 and and familiar with the NICE guidelines on thyroid management.
I would prefer to have a medical professional on-side with any treatments I might find myself needing - Im thinking here of possible
combination
therapy
. I fully understand the commissioning issues around the prescribing go t3 and and familiar with the NICE guidelines on thyroid management.
SOT1512
in
Thyroid UK
6 months ago
European Society for Medical Oncology Congress - ESMO 2023 - Two Significant Lutetium Trials -mCRPC
Data from the study showed a median PSA-PSF of 13 months with the
combination
therapy
compared with 7.8 months with enzalutamide alone. Median radiographic PFS was 16 months with the
combination
therapy
compared with 12 months for enzalutamide.
Data from the study showed a median PSA-PSF of 13 months with the
combination
therapy
compared with 7.8 months with enzalutamide alone. Median radiographic PFS was 16 months with the
combination
therapy
compared with 12 months for enzalutamide.
marnieg46
in
Fight Prostate Cancer
6 months ago
TAPUR study
. 🙏🏻 Public system only funds CDK4/6 initially ie Ibrance yet it is the AI, Arimadex that invariably fails and
combination
therapy
could be continued with say Verzenio, Fulvestrant as informed by genomics. An analysis suggested CDK4/6 could be held in reserve thus saving money.
. 🙏🏻 Public system only funds CDK4/6 initially ie Ibrance yet it is the AI, Arimadex that invariably fails and
combination
therapy
could be continued with say Verzenio, Fulvestrant as informed by genomics. An analysis suggested CDK4/6 could be held in reserve thus saving money.
muzzatron
in
SHARE Metastatic Breast Cancer
4 months ago
Switching from T4-T3 combination to NDT
And should I split it during the day, the way I do with the
combination
therapy
? What should I look for when doing the switch?
And should I split it during the day, the way I do with the
combination
therapy
? What should I look for when doing the switch?
Alex_p
in
Thyroid UK
10 months ago
Invitro study shows Delta Tocotrienol overcomes Docetaxel resistence in PCa
Combination
therapy
is one tool used to overcome therapeutic resistance and drug toxicity. Evaluating the combined effect of δ-TT and docetaxel (DTX), we found that δ-TT potentiates DTX cytotoxicity in DU145 cells.
Combination
therapy
is one tool used to overcome therapeutic resistance and drug toxicity. Evaluating the combined effect of δ-TT and docetaxel (DTX), we found that δ-TT potentiates DTX cytotoxicity in DU145 cells.
Graham49
in
Fight Prostate Cancer
8 months ago
Efficacy and safety of new‑generation BTKis (primarily acalabrutinib and zanubrutinib) in CLL/SLL: a systematic review and meta‑analysis
[/i] [i]Despite the superior efficacy of BTKi
combination
therapy
compared to monotherapy, its AEs rates are relatively high. Compared to acalabrutinib, Zanubrutinib may be the preferred monotherapy for CLL. However, randomized-controlled studies are still needed.
[/i] [i]Despite the superior efficacy of BTKi
combination
therapy
compared to monotherapy, its AEs rates are relatively high. Compared to acalabrutinib, Zanubrutinib may be the preferred monotherapy for CLL. However, randomized-controlled studies are still needed.
AussieNeil
Administrator
in
CLL Support
6 months ago
BTA and 'T3 does not cross the placenta'
Until the introduction of levothyroxine ALL babies were born to mothers on '
combination
therapy
', usually a
combination
of T3 and T4 from the mother's thyroid. I am asking as part of the Ask for Evidence campaign and will share the response I get publicly.
Until the introduction of levothyroxine ALL babies were born to mothers on '
combination
therapy
', usually a
combination
of T3 and T4 from the mother's thyroid. I am asking as part of the Ask for Evidence campaign and will share the response I get publicly.
jimh111
in
Thyroid UK
8 months ago
Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?
A practical approach to patients with residual symptoms and on initiation of
combination
therapy
with LT4 + LT3 is provided.
A practical approach to patients with residual symptoms and on initiation of
combination
therapy
with LT4 + LT3 is provided.
helvella
Thyroid UK
in
Thyroid UK
10 months ago
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