Protein discovery could help solve prostate cancer drug resistance Date:January 22, 2024 Source:Washington State University

[MsHope]

I found this information while researching my husband's PSA rising issues. Found it interesting and want to share. Click on link to read the entire article sciencedaily.com/

Protein discovery could help solve prostate cancer drug resistance

Date:

January 22, 2024

Source:

Washington State University

Summary:

Researchers have identified a receptor protein known as CHRM1 as a key player in prostate cancer cells' resistance to docetaxel, a commonly used chemotherapy drug to treat advanced cancer that has spread beyond the prostate. The study showed that using the drug dicyclomine to block CHRM1 in resistant prostate cancer cell lines and an animal model based on patient-derived resistant tissue restored docetaxel's ability to kill cells and stop tumor growth. Dicyclomine is already on the market as a drug to treat symptoms of inflammatory bowel syndrome. The discovery opens the door to new combination treatment strategies that could overcome docetaxel resistance in prostate cancer and perhaps other cancers, which could help extend the lives of patients.

The researchers did this by using dicyclomine, a drug that selectively inhibits CHRM1 activity.

Dicyclomine is already on the market as a generic drug and is currently used to treat symptoms of irritable bowel syndrome.

"The effect was pretty dramatic in all the experimental models we tested," said Boyang (Jason) Wu, an associate professor in the WSU College of Pharmacy and Pharmaceutical Sciences and co-senior author on the study.

"And because dicyclomine already has a clinical use, this work has immediate translational potential."

Published in the journal Cell Reports Medicine, the researchers' findings support clinical testing to confirm whether combined use of docetaxel and dicyclomine could help overcome treatment resistance in prostate cancer patients.

Docetaxel resistance can develop in prostate cancer after about six months of treatment.

Wu said this type of combination therapy could also potentially be used for other cancers that are currently being treated with docetaxel, such as breast and lung cancer.

It may also be possible to use the same combination strategy with other similar chemotherapy drugs.

[HikerWife]

Very interesting, thanks for sharing. Saving to my files!

[MsHope in reply to HikerWife]

Glad to share

[Scout4answers]

Nice find, something to watch for.

Thinking out loud, perhaps dicyclomine could be used on its own to prevent progression. in those of us who are hormone sensitive

[MsHope in reply to Scout4answers]

I thought it was interesting and it doesn't hurt to as doctor

[CousinGrandpa]

Excellent report. Hopefully it will open doors to extend treatment with ADT, ARPI as well as chemo.

[MsHope in reply to CousinGrandpa]

I too hope it will help

[Papillon2]

Thnx for sharing. 👍👍👍

[j-o-h-n]

Shoot, I resist taking my meds, does that count?

Good Luck, Good Health and Good Humor.

j-o-h-n