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Venetoclax Added to Ibrutinib in High-Risk CLL Achieves a High Rate of Undetectable Minimal Residual Disease.
December 8, 2019 ASH poster. There are lots of us on long term Ibrutinib who have had a good response but still have a small amount of residual disease. I would welcome the chance to add venetoclax to my treatment as in this study which is an important piece of work by Michael J Keating et al. "[i]Patients
December 8, 2019 ASH poster. There are lots of us on long term Ibrutinib who have had a good response but still have a small amount of residual disease. I would welcome the chance to add venetoclax to my treatment as in this study which is an important piece of work by Michael J Keating et al. "[i]Patients
Jm954
Administrator
in
CLL Support
4 years ago
The TP53 mutational landscape in CLL is very complex
December 8, 2019 Interesting poster shedding a bit more light on the complexity of TP53 mutations and its independence from 17p deletion. [i]"TP53 aberrations, including somatic mutations of TP53 gene or 17p deletion leading to the loss of the TP53 locus, are a major predictive factor of resistance to
December 8, 2019 Interesting poster shedding a bit more light on the complexity of TP53 mutations and its independence from 17p deletion. [i]"TP53 aberrations, including somatic mutations of TP53 gene or 17p deletion leading to the loss of the TP53 locus, are a major predictive factor of resistance to
Jm954
Administrator
in
CLL Support
4 years ago
Suprecur as trigger?
Following my consultation with the founder of my clinic, I'm going to be doing a combination of cycle 1 (long protocol) and cycle 2 (antagonist) meds for cycle 3. As I'm high risk of OHSS she said she might use suprecur as the trigger. Has anyone ever done this as I've only ever used ovitrelle before
Following my consultation with the founder of my clinic, I'm going to be doing a combination of cycle 1 (long protocol) and cycle 2 (antagonist) meds for cycle 3. As I'm high risk of OHSS she said she might use suprecur as the trigger. Has anyone ever done this as I've only ever used ovitrelle before
Jessy1280
in
Fertility Network UK
4 years ago
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CD3xCD19 Dart Treatment Is Efficient in Venetoclax Resistant CLL and Reverses T Cell Dysfunction
DART (rather than CART) treatment could be come important in the future, especially for CLL where the T cells become exhausted and don't function appropriately. We often think that Venetoclax works for everyone but sadly that isn't true and this in vitro (lab) study on CLL cells, although at very early
DART (rather than CART) treatment could be come important in the future, especially for CLL where the T cells become exhausted and don't function appropriately. We often think that Venetoclax works for everyone but sadly that isn't true and this in vitro (lab) study on CLL cells, although at very early
Jm954
Administrator
in
CLL Support
4 years ago
Pregnancy 1st Trimester Results. Should I be concerned?
Hi I am first in first trimester of pregnancy. Week 4+3 I have Hashimotos and am hypo. I have general had this under control for some time now. However my September results were Free t4 22.6 range 12-22 Tsh 0.11 range 0.27-4.20 T3 5.8 range unknown I normally do well at the higher end of the range
Hi I am first in first trimester of pregnancy. Week 4+3 I have Hashimotos and am hypo. I have general had this under control for some time now. However my September results were Free t4 22.6 range 12-22 Tsh 0.11 range 0.27-4.20 T3 5.8 range unknown I normally do well at the higher end of the range
Wee_Bird
in
Thyroid UK
4 years ago
Letrozole causing late ovulation?
I wondered if anyone has any experience of having a late ovulation on letrozole? I usually have short cycles (23-26 days), ovulating on day 14, with a short luteal phase. This month I'm on letrozole for the first time but it's day 19 and still no positive ovulation test... Could the letrozole have delayed
I wondered if anyone has any experience of having a late ovulation on letrozole? I usually have short cycles (23-26 days), ovulating on day 14, with a short luteal phase. This month I'm on letrozole for the first time but it's day 19 and still no positive ovulation test... Could the letrozole have delayed
Sylva123
in
Fertility Network UK
4 years ago
Long time DX,SORT TIME TMT
I was diagnosed with CLL in 1995. I’ve been on W&W until this year in Sept. at age 86. Treatment was initiated Ibrutinib 140mg, orally per diem. I’ve positive movement with my numbers and the splenomegaly. My nodes were minimally involved. My side effects have been undetectable. Given good response
I was diagnosed with CLL in 1995. I’ve been on W&W until this year in Sept. at age 86. Treatment was initiated Ibrutinib 140mg, orally per diem. I’ve positive movement with my numbers and the splenomegaly. My nodes were minimally involved. My side effects have been undetectable. Given good response
desti
in
CLL Support
4 years ago
Dr Michael Keating's Story - Taking CLL Therapies From Bedside to Community
A fascinating overview of one of the giants in CLL research, who provided many of us with the first treatment capable of prolonging life expectancy (FCR) and for about 60% of those who are mutated IgHV, effectively a cure. From humble beginnings in Melbourne Australia, to a fulfilling career at the
A fascinating overview of one of the giants in CLL research, who provided many of us with the first treatment capable of prolonging life expectancy (FCR) and for about 60% of those who are mutated IgHV, effectively a cure. From humble beginnings in Melbourne Australia, to a fulfilling career at the
AussieNeil
Administrator
in
CLL Support
4 years ago
Slight bad news
Hi just over 5 months since liver transplant and had call from consultant after clinic visit on Tuesday. I need a liver scan so I presume when bloods taken not good. Hopefully it can be sopted. I have just come off mycophenolate tablets and have been put on prednisolone again. See what happens. I supposed
Hi just over 5 months since liver transplant and had call from consultant after clinic visit on Tuesday. I need a liver scan so I presume when bloods taken not good. Hopefully it can be sopted. I have just come off mycophenolate tablets and have been put on prednisolone again. See what happens. I supposed
Steak
in
British Liver Trust
5 years ago
IVGH results
Hello. I am new to the group, just diagnosed this month. My last CBC showed absolute lymphocytes at 5280. I was feeling pretty good after my doctor explained what CLL is, how it progresses etc. But today I got results of another test back with the following: IVGH Borderline Mutated Mutation Rate 3.0
Hello. I am new to the group, just diagnosed this month. My last CBC showed absolute lymphocytes at 5280. I was feeling pretty good after my doctor explained what CLL is, how it progresses etc. But today I got results of another test back with the following: IVGH Borderline Mutated Mutation Rate 3.0
lmav
in
CLL Support
4 years ago
Clinical Utility of Chromosomal Microarray in Richter's Transformation
Chromosomal microarray (CMA) is clever, very sensitive technology which looks for extra (duplicated) or missing (deleted) chromosomal segments, sometimes called copy number variants (CNVs) - see illustration. These include: microdeletions and microduplications of chromosome segments, which are too
Chromosomal microarray (CMA) is clever, very sensitive technology which looks for extra (duplicated) or missing (deleted) chromosomal segments, sometimes called copy number variants (CNVs) - see illustration. These include: microdeletions and microduplications of chromosome segments, which are too
Jm954
Administrator
in
CLL Support
4 years ago
Discomfort
I was diagnosed with Copd in 2015 , since then I was diagnosed with heart failure but a recent angiogram gave a good result with no arteries problems & before that the cardiologist was pleased with me. I am not gasping for breath with the Copd but I get discomforted with doing the least thing and
I was diagnosed with Copd in 2015 , since then I was diagnosed with heart failure but a recent angiogram gave a good result with no arteries problems & before that the cardiologist was pleased with me. I am not gasping for breath with the Copd but I get discomforted with doing the least thing and
paulc20-
in
Lung Conditions Community Forum
4 years ago
AF and heart failure
My husband is 57, went into ER in January and diagnosed with AF and heart failure. After cardioversion and anti-arrhythmic drugs, as well as metoprolol (beta blocker) and lisinopryl (ACE inhibitor), he has had no more AF and his heart failure drastically improved by March. And he had an ablation about
My husband is 57, went into ER in January and diagnosed with AF and heart failure. After cardioversion and anti-arrhythmic drugs, as well as metoprolol (beta blocker) and lisinopryl (ACE inhibitor), he has had no more AF and his heart failure drastically improved by March. And he had an ablation about
Waverly1
in
AF Association
4 years ago
Have just spent a week in Hospital with chest infection which has agrevated my A/F and given me slight heart failure. How long to recover ?
This came on by feeling a bit breathless six weeks ago. I am still feeling tired and rough a lot on the time saw heart failure nurse today who put me on Ramipril as well as Bisoprolol 5mg twice per and Digoxin 125mcg per per day. Any advice would be appreciated.
This came on by feeling a bit breathless six weeks ago. I am still feeling tired and rough a lot on the time saw heart failure nurse today who put me on Ramipril as well as Bisoprolol 5mg twice per and Digoxin 125mcg per per day. Any advice would be appreciated.
Mike-tyson
in
Anxiety Support
4 years ago
5 weeks exactly but nothing on scan
Hi ladies, I am hoping someone could help me put my mind at rest or even give me some guidance. My otd was 26 December I tested on 23 December and received a BFP. I then tested otd and got a positive again (so lucky I know) I went for a scan yesterday because my tummy was so swollen and they were
Hi ladies, I am hoping someone could help me put my mind at rest or even give me some guidance. My otd was 26 December I tested on 23 December and received a BFP. I then tested otd and got a positive again (so lucky I know) I went for a scan yesterday because my tummy was so swollen and they were
Chels_17
in
Fertility Network UK
4 years ago
CALQUENCE gets FDA approval for treating CLL
The latest approval for Calquence (acalabrutinib), a Bruton tyrosine kinase (BTK) inhibitor, was granted under the FDA’s Real-Time Oncology Review and newly established Project Orbis programs. Calquence binds covalently to BTK, thereby inhibiting its activity. In B-cells, BTK signaling results in activation
The latest approval for Calquence (acalabrutinib), a Bruton tyrosine kinase (BTK) inhibitor, was granted under the FDA’s Real-Time Oncology Review and newly established Project Orbis programs. Calquence binds covalently to BTK, thereby inhibiting its activity. In B-cells, BTK signaling results in activation
Myrddin
in
CLL Support
4 years ago
Robotic catheter ablation
Hi, I’m scheduled for robotic catheter ablation with the Stereotaxis system. I’ve had PVCs (pre-ventricular contractions, an arrhythmia not mentioned much in these posts) since my early teens (for about 50 years), and a recent holter showed that 21% of my heartbeats are now irregular. Monitored but untreated
Hi, I’m scheduled for robotic catheter ablation with the Stereotaxis system. I’ve had PVCs (pre-ventricular contractions, an arrhythmia not mentioned much in these posts) since my early teens (for about 50 years), and a recent holter showed that 21% of my heartbeats are now irregular. Monitored but untreated
Pinetar
in
AF Association
4 years ago
Can Iron deficiency cause AF ?
A blood test several months ago showed up low ferritin levels and 3 months after I had my first AF which I had a cardioversion for. Last week I had a new blood test and my ferritin level is exactly the same even after taking iron tablets for 6 months. After doing research I found that low iron is common
A blood test several months ago showed up low ferritin levels and 3 months after I had my first AF which I had a cardioversion for. Last week I had a new blood test and my ferritin level is exactly the same even after taking iron tablets for 6 months. After doing research I found that low iron is common
sandoval22
in
AF Association
4 years ago
Update- Chemical Pregnancy confirmed
Feeling heartbroken. The call from the hospital was what I expected, but it doesn’t hurt any less. My HCG levels have dropped to 7, and I have to go back for another blood test in a week. It’s crazy I was on such a high over the last few days. Now I feel broken. I know in time I’ll feel better. But this
Feeling heartbroken. The call from the hospital was what I expected, but it doesn’t hurt any less. My HCG levels have dropped to 7, and I have to go back for another blood test in a week. It’s crazy I was on such a high over the last few days. Now I feel broken. I know in time I’ll feel better. But this
Gem2410
in
Fertility Network UK
4 years ago
2 months post kidney transplant
Hello everyone! I am a new member here and was really happy to found this group. I am 27 years old and of my kidneys failed due to HSP (Henoch Schonlein Purpura) April of last year. I was on hemodialysis for a over year and I am super blessed to received a call from my Transplant Center back in July
Hello everyone! I am a new member here and was really happy to found this group. I am 27 years old and of my kidneys failed due to HSP (Henoch Schonlein Purpura) April of last year. I was on hemodialysis for a over year and I am super blessed to received a call from my Transplant Center back in July
Trouper
in
Kidney Transplant Patient Support
5 years ago
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