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Darolutamide and Desunomab Questions
Prostate was radiated in 2021 and pelvic node and pelvis in 2023. Cancer is growing prostate, shrinking in pelvic node, and spread to an abdominal node. Opinions are welcome on two subjects. I have started on ADT Orgovyx with no side effects in a month. The urologist plans to add an ARI (reception
Prostate was radiated in 2021 and pelvic node and pelvis in 2023. Cancer is growing prostate, shrinking in pelvic node, and spread to an abdominal node. Opinions are welcome on two subjects. I have started on ADT Orgovyx with no side effects in a month. The urologist plans to add an ARI (reception
vintage42
in
Advanced Prostate Cancer
7 months ago
Overwhelmed, what do I do next? Mutations In my Germline & a Tier 1 ATM Frameshift Alteration
My Germline is I’m missing a blm copy like a bloom syndrome drop My Genomic Tier 1 is a ATM Frameshift Alteration I have a battery of mutations listed in my profile bio. My PSA in the last 4 months is rising from <0.06 in October to 0.46 last week. I’m on Firmagon monthly, Zytiga with Prednisone
My Germline is I’m missing a blm copy like a bloom syndrome drop My Genomic Tier 1 is a ATM Frameshift Alteration I have a battery of mutations listed in my profile bio. My PSA in the last 4 months is rising from <0.06 in October to 0.46 last week. I’m on Firmagon monthly, Zytiga with Prednisone
Shorehousejam
in
Advanced Prostate Cancer
7 months ago
Treatment Options
PSA 4.7 (over 2 years it double and then doubled again) This is the Pathology report A: Prostate gland, left lateral posterior, biopsy: Benign prostatic tissue with mild chronic inflammation, no tumor present. B: Prostate gland, left lateral mid, biopsy: Benign prostatic tissue with mild chronic
PSA 4.7 (over 2 years it double and then doubled again) This is the Pathology report A: Prostate gland, left lateral posterior, biopsy: Benign prostatic tissue with mild chronic inflammation, no tumor present. B: Prostate gland, left lateral mid, biopsy: Benign prostatic tissue with mild chronic
Vortex12
in
Prostate Cancer Network
7 months ago
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Any Data or MO Advice Regarding Dutasteride / Finasteride At Very Early Biochemical Recurrence?
Does anyone know of any studies or MO advice they've gotten regarding use of Dutasteride or Finasteride at very early signs of Biochemical Reccurrence (uPSA in the 0.03 - 0.1 range) prior to Salvage Radiotherapy? It's obviously going to slow PSA doubling time and thereby probably lengthen the time
Does anyone know of any studies or MO advice they've gotten regarding use of Dutasteride or Finasteride at very early signs of Biochemical Reccurrence (uPSA in the 0.03 - 0.1 range) prior to Salvage Radiotherapy? It's obviously going to slow PSA doubling time and thereby probably lengthen the time
jazj
in
Advanced Prostate Cancer
7 months ago
PSA Response From Broccoli Sprout Extract (Sulforaphane) May Due To Just Being Moderate ADT
I forgot I ran across this a 2 years ago as many with PCa diagnosis are very interested in Sulforaphane due to a lot of excitement from a few studies a few years ago. (This fueled an explosion of supplements on Amazon.) This however is one of the more expensive supplements and my jury is still out
I forgot I ran across this a 2 years ago as many with PCa diagnosis are very interested in Sulforaphane due to a lot of excitement from a few studies a few years ago. (This fueled an explosion of supplements on Amazon.) This however is one of the more expensive supplements and my jury is still out
jazj
in
Advanced Prostate Cancer
7 months ago
Declining psa #9
Gm folks, hope all are having a wonderful New Year. I’m following up n giving results on using ivermectin, cbd oil, turmeric Vit b3,6,12 Vit c And zinc solely after eliminating ADT after 7 months, post Rp n rad… Psa dropped another .29 points to .66 down from .95 n psa was hovering 7 when I first got
Gm folks, hope all are having a wonderful New Year. I’m following up n giving results on using ivermectin, cbd oil, turmeric Vit b3,6,12 Vit c And zinc solely after eliminating ADT after 7 months, post Rp n rad… Psa dropped another .29 points to .66 down from .95 n psa was hovering 7 when I first got
Nfler
in
Advanced Prostate Cancer
7 months ago
Stratification test for ADT effectiveness
As someone who has had the awful experience of ADT side effects, I give this tool a standing ovation: https://artera.ai/arteraai-prostate-cancer-test Just approved for Medicare coverage, and just a matter of time before California and New York join the other 48 states in approving it.
As someone who has had the awful experience of ADT side effects, I give this tool a standing ovation: https://artera.ai/arteraai-prostate-cancer-test Just approved for Medicare coverage, and just a matter of time before California and New York join the other 48 states in approving it.
ron_bucher
in
Advanced Prostate Cancer
7 months ago
SRBT and EXTEND trial
Does anybody have the full text of EXTEND trial results from June 2023? (my payment attempt is rejected and the tips on how to get a study without cost doesn´t work) https://pubmed.ncbi.nlm.nih.gov/37022702/ Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic
Does anybody have the full text of EXTEND trial results from June 2023? (my payment attempt is rejected and the tips on how to get a study without cost doesn´t work) https://pubmed.ncbi.nlm.nih.gov/37022702/ Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic
Purple-Bike
in
Advanced Prostate Cancer
7 months ago
What is the next step
I have one more Immunotherapy for my bladder cancer, so far all scan have shown no metastasis. Now I need to focus on my PC after more than a year of ignoring it. My PSA has been fluctuating and is now 0.65, doubling time is 16 months, I have not had ADT yet and my MO wants to just wait and watch. What
I have one more Immunotherapy for my bladder cancer, so far all scan have shown no metastasis. Now I need to focus on my PC after more than a year of ignoring it. My PSA has been fluctuating and is now 0.65, doubling time is 16 months, I have not had ADT yet and my MO wants to just wait and watch. What
old64horn
in
Advanced Prostate Cancer
7 months ago
Follow up to "My trajectory after a 'vacation' and a new metastasis," and a new question
I though that the recommendation of the "tumor board" at Smilow Cancer Center in New Haven, CT, would be "doublet therapy" to treat the new metastasis that was found with a PET PSMA scan, (the second one that was found after my Lupron "vacation"; the first was treated with radiation--details of my case
I though that the recommendation of the "tumor board" at Smilow Cancer Center in New Haven, CT, would be "doublet therapy" to treat the new metastasis that was found with a PET PSMA scan, (the second one that was found after my Lupron "vacation"; the first was treated with radiation--details of my case
Istomin
in
Advanced Prostate Cancer
7 months ago
ASCO 2023: AI-Derived Digital Pathology Biomarker Predicts Benefit of Long-Term ADT with Radiotherapy in Localized High-Risk Prostate Cancer
https://www.urotoday.com/conference-highlights/asco-2023/asco-2023-prostate-cancer/144902-asco-2023-development-and-validation-of-an-ai-derived-digital-pathology-based-biomarker-to-predict-benefit-of-long-term-androgen-deprivation-therapy-with-radiotherapy-in-men-with-localized-high-risk-prostate-cancer-across-multiple-phase-iii-nrg-rtog-trials.html
https://www.urotoday.com/conference-highlights/asco-2023/asco-2023-prostate-cancer/144902-asco-2023-development-and-validation-of-an-ai-derived-digital-pathology-based-biomarker-to-predict-benefit-of-long-term-androgen-deprivation-therapy-with-radiotherapy-in-men-with-localized-high-risk-prostate-cancer-across-multiple-phase-iii-nrg-rtog-trials.html
zeitgeistxx
in
Advanced Prostate Cancer
7 months ago
Short-term vs Long-Term ADT for High Risk Men
Here's a review of a recent presentation at ASCO 2023 by Artera.ai regarding the use of Artificial Intelligence analysis of biopsy slides to predict which high-risk men do or don't benefit from short-term ADT vs long-term ADT. Their findings are summarized here: [i]"Based on these results, it appears
Here's a review of a recent presentation at ASCO 2023 by Artera.ai regarding the use of Artificial Intelligence analysis of biopsy slides to predict which high-risk men do or don't benefit from short-term ADT vs long-term ADT. Their findings are summarized here: [i]"Based on these results, it appears
janebob99
in
Prostate Cancer Network
7 months ago
Managing OAB after proton RT
Hello everyone, This 73 year old treated an unfavorable intermediate localized PCa with 28 fractions of proton radiation, completed on Dec. 15th. Completed a 4 months course of oral Orgovyx on Dec. 28th. The side effects of the ADT were hot flashes (tolerable) and loss of libido. The side effects
Hello everyone, This 73 year old treated an unfavorable intermediate localized PCa with 28 fractions of proton radiation, completed on Dec. 15th. Completed a 4 months course of oral Orgovyx on Dec. 28th. The side effects of the ADT were hot flashes (tolerable) and loss of libido. The side effects
old_reliable
in
Prostate Cancer Network
7 months ago
Will T return?
As I near the end of my 2 years of ADT (Lupron + Abi), I am curious if I should expect a return of Testosterone. I would love to regain my libido and endurance. But after 2 years, I don't know what to expect. My MO has been pretty vague about what to expect. Another issue is that I didn't have a
As I near the end of my 2 years of ADT (Lupron + Abi), I am curious if I should expect a return of Testosterone. I would love to regain my libido and endurance. But after 2 years, I don't know what to expect. My MO has been pretty vague about what to expect. Another issue is that I didn't have a
jmarsh
in
Advanced Prostate Cancer
7 months ago
PSA 6 months after RT
Here is a review of a presentationby Dr. Ravi at ASCO 2023, regarding measuring the PSA at 6 months post radiation treatment, for all risk groups. He found that the 6-month post-RT PSA was highly prognostic of 5- and 10-year rates of metastasis free survival (MFS), Overall Survival (OS), and prostate
Here is a review of a presentationby Dr. Ravi at ASCO 2023, regarding measuring the PSA at 6 months post radiation treatment, for all risk groups. He found that the 6-month post-RT PSA was highly prognostic of 5- and 10-year rates of metastasis free survival (MFS), Overall Survival (OS), and prostate
janebob99
in
Prostate Cancer Network
7 months ago
Testosterone was nearly back to normal, then dropped
I had a year of Lupron and Enzalutamide in 2022. Testosterone slowly came back to a high of about 240 in June and Sept 2023. Normal for me is around 350 - 375. Now this week T is down to 156. Is this sort of fluctuation normal? I had 6 months of ADT in connection with radiation for recurrent PCa
I had a year of Lupron and Enzalutamide in 2022. Testosterone slowly came back to a high of about 240 in June and Sept 2023. Normal for me is around 350 - 375. Now this week T is down to 156. Is this sort of fluctuation normal? I had 6 months of ADT in connection with radiation for recurrent PCa
Teddy28
in
Advanced Prostate Cancer
7 months ago
BONE DENSITY TEST IS BAD
I am 68 with low volume metastatic to hip bones. Nothing elsewhere, at this time. Had PSA of 125 last April, and oncologist put me on Relogolix and Darolutemide. That along with going to plant based diet and adding weights and HITT exercise 3-4x per week, has brought me down to < .006. that’s the
I am 68 with low volume metastatic to hip bones. Nothing elsewhere, at this time. Had PSA of 125 last April, and oncologist put me on Relogolix and Darolutemide. That along with going to plant based diet and adding weights and HITT exercise 3-4x per week, has brought me down to < .006. that’s the
JL1955
in
Advanced Prostate Cancer
7 months ago
Holding very low stable usPSA - 0.03X range for six years; no ADT, no chemo.
Eight years ago this month had RP after considerable investigation - nadir 0.050. Eleven months later had salvage RT; done at 0.10. Then after a year of pondering ADT and chemo, when my usPSA was back up to 0.10, I went to Europe for Ferrotran nano-MRI combined with Ga68 PSMA. The nanoMRI lite up
Eight years ago this month had RP after considerable investigation - nadir 0.050. Eleven months later had salvage RT; done at 0.10. Then after a year of pondering ADT and chemo, when my usPSA was back up to 0.10, I went to Europe for Ferrotran nano-MRI combined with Ga68 PSMA. The nanoMRI lite up
NanoMRI
in
Advanced Prostate Cancer
7 months ago
Spine metastasis
My father in law is 78 year old male with PCA with what appears to be a single spine metastasis. Gleason 7 ( 4+3) We have an appointment coming up with the radiation oncologist . Is this something they would get a PSMA TEST for to confirm and also would he just receive ADT with radiation to primary site
My father in law is 78 year old male with PCA with what appears to be a single spine metastasis. Gleason 7 ( 4+3) We have an appointment coming up with the radiation oncologist . Is this something they would get a PSMA TEST for to confirm and also would he just receive ADT with radiation to primary site
Telegraph2022
in
Advanced Prostate Cancer
7 months ago
Full circle with this disease
Diagnosed 2017 PSA 105 started ADT, 6 rounds Docetaxel and radiation PSA drops to undetectable. Castrate resistant 2022 started Abiraterone and prednisone this failed after 3 months. Start Xgeva and Xofigo 2023. PSA back at 105 November 2023. Start 10 rounds of Docetaxel and PSA starts dropping again
Diagnosed 2017 PSA 105 started ADT, 6 rounds Docetaxel and radiation PSA drops to undetectable. Castrate resistant 2022 started Abiraterone and prednisone this failed after 3 months. Start Xgeva and Xofigo 2023. PSA back at 105 November 2023. Start 10 rounds of Docetaxel and PSA starts dropping again
Islandboy2021
in
Advanced Prostate Cancer
7 months ago
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