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Alendronic acid / Colecalciferol
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PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong
Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Glycyrrhizin in licorice root is a novel pharmacological inhibition of HMGB1 that repress prostate cancer metastasis
High mobility group box 1 (HMGB1) is upregulated in nearly every tumor type. Importantly, clinical evidence also proposed that HMGB1 is particularly increased in metastatic prostate cancer patients. Besides, a growing number of studies highlighted that HMGB1 could be a successful therapeutic target for
High mobility group box 1 (HMGB1) is upregulated in nearly every tumor type. Importantly, clinical evidence also proposed that HMGB1 is particularly increased in metastatic prostate cancer patients. Besides, a growing number of studies highlighted that HMGB1 could be a successful therapeutic target for
Hidden
in
Advanced Prostate Cancer
2 years ago
Introducing myself as a new member
Hi, I'm new here, just diagnosed and am interested in controlling further bone loss with way of eating. I am about 90% vegan but would like to ramp up my food sources (e.g. green leafy veggies, etc.) and strength/weight training to help with this condition. I am 71 years old, not taking any medications
Hi, I'm new here, just diagnosed and am interested in controlling further bone loss with way of eating. I am about 90% vegan but would like to ramp up my food sources (e.g. green leafy veggies, etc.) and strength/weight training to help with this condition. I am 71 years old, not taking any medications
SwimLMich
in
Osteoporosis Support
2 years ago
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Omega Blood Results
Hello 👋 I take Omega liquid supplement by Now from iHerb, 1.4g a day, high amounts of EPA and DHA. Had a complimentary test from LetsGetChecked and received my Omega 6 to Omega 3 ratio results today: Omega 6: Omega 3 6:1 (1.5-3.0) The report says I should have ratio up to 3:1 and any higher is bad
Hello 👋 I take Omega liquid supplement by Now from iHerb, 1.4g a day, high amounts of EPA and DHA. Had a complimentary test from LetsGetChecked and received my Omega 6 to Omega 3 ratio results today: Omega 6: Omega 3 6:1 (1.5-3.0) The report says I should have ratio up to 3:1 and any higher is bad
Incoguto
in
Thyroid UK
2 years ago
Cerrelle constant bleeding
I was given the progesterone only pill because I can’t take the combination pill as I have aurora migraines and it increases the risk of stroke. Well I have been bleeding constantly for two weeks. I’ve been on it for 5 weeks. I can handle the annoyance of a constant period but not the pain and discomfort
I was given the progesterone only pill because I can’t take the combination pill as I have aurora migraines and it increases the risk of stroke. Well I have been bleeding constantly for two weeks. I’ve been on it for 5 weeks. I can handle the annoyance of a constant period but not the pain and discomfort
ZebraZone
in
Endometriosis UK
2 years ago
The magic of a backpack
Throughout my life I found myself losing things all the time. In fact I found it very difficult to leave the house sometimes due to the things that I’ve lost or misplaced. One of my girlfriends in the past give me a small bag which are used to store some of the things I needed most commonly. It started
Throughout my life I found myself losing things all the time. In fact I found it very difficult to leave the house sometimes due to the things that I’ve lost or misplaced. One of my girlfriends in the past give me a small bag which are used to store some of the things I needed most commonly. It started
DistractedAlways31
in
CHADD's Adult ADHD Support
2 years ago
Advice on Recent Bloods Please
Hello All, Many thanks again for your help a few weeks ago. I got the postal kit from Lets Get Checked and got the results on Friday. Prior to doing the blood tests I had tried splitting my 2x 60mg NP Thyroid dose into 2 doses - 1 tablet early morning a couple of hours before I am due to get up and the
Hello All, Many thanks again for your help a few weeks ago. I got the postal kit from Lets Get Checked and got the results on Friday. Prior to doing the blood tests I had tried splitting my 2x 60mg NP Thyroid dose into 2 doses - 1 tablet early morning a couple of hours before I am due to get up and the
CMDK2020
in
Thyroid UK
2 years ago
Please help. Where do I go next?
I had my first gynaecology appointment this morning and have come away feeling like I haven’t been listened to and my symptoms are not real. I am considering my next steps and whether to go back to my GP. I had been waiting 1.5 years for this appointment and feel very upset that I may now not get any
I had my first gynaecology appointment this morning and have come away feeling like I haven’t been listened to and my symptoms are not real. I am considering my next steps and whether to go back to my GP. I had been waiting 1.5 years for this appointment and feel very upset that I may now not get any
sweetpea2288
in
Endometriosis UK
2 years ago
Cholesterol over range despite weight loss and dieting - what’s going on?
Hi everyone, I was wondering if I could get some advice on my recent Medichecks results. I got the well woman check to check a few things I was concerned about monitoring including my cholesterol. My previous check last year showed my cholesterol was high but still in normal range but now my results
Hi everyone, I was wondering if I could get some advice on my recent Medichecks results. I got the well woman check to check a few things I was concerned about monitoring including my cholesterol. My previous check last year showed my cholesterol was high but still in normal range but now my results
Newmummy82
in
Thyroid UK
2 years ago
Best, value for money Supplements
So SI B12, have run out of all my supplements. Now on 150 mcg Levo, I need Vit D, K2 MK7, Folate/B complex, Magnesium, maybe glycinate or chloride, spent hours trying to track down good bio available ones and getting confused and annoyed. omega 3 fatty
So SI B12, have run out of all my supplements. Now on 150 mcg Levo, I need Vit D, K2 MK7, Folate/B complex, Magnesium, maybe glycinate or chloride, spent hours trying to track down good bio available ones and getting confused and annoyed. omega 3 fatty
Polo22
in
Pernicious Anaemia Society
2 years ago
Antabuse (disulfiram) Anyone using this for Macular degeneration?
Has anyone be using Antabuse for AMD? What country and hospital? Have you found improment in your vision? Any other comments? best regards de-luke The Full Scientific Paper Can Be Found Here- https://www.science.org/doi/10.1126/sciadv.abm4643 Summary- Rod and cone photoreceptors degenerate in retinitis
Has anyone be using Antabuse for AMD? What country and hospital? Have you found improment in your vision? Any other comments? best regards de-luke The Full Scientific Paper Can Be Found Here- https://www.science.org/doi/10.1126/sciadv.abm4643 Summary- Rod and cone photoreceptors degenerate in retinitis
de-luke
in
Macular Society
2 years ago
Alendronic Acid and Evacal D3
Hi is anyone on these two medications and getting Stomach aches/headaches and feeling nauseous? I have been placed on these 6 weeks ago and I'm not feeling great! Even thought at one stage that I had Covid symptoms. (Didn't/Don't as get tested daily for work!) Have got in touch with my Rheumy dept and
Hi is anyone on these two medications and getting Stomach aches/headaches and feeling nauseous? I have been placed on these 6 weeks ago and I'm not feeling great! Even thought at one stage that I had Covid symptoms. (Didn't/Don't as get tested daily for work!) Have got in touch with my Rheumy dept and
scorpiojack
in
NRAS
3 years ago
Billing for Infusions
Does anyone know how the price of Zoledronic Acid is affected by whether it is given in a rheumatology practice's infusion center versus picked up by the patient at a pharmacy and given at a doctor's office? My rheumatologist says I may have to pick up infusion medication if I need to take it. She is
Does anyone know how the price of Zoledronic Acid is affected by whether it is given in a rheumatology practice's infusion center versus picked up by the patient at a pharmacy and given at a doctor's office? My rheumatologist says I may have to pick up infusion medication if I need to take it. She is
Lynnel17
in
Osteoporosis Support
2 years ago
Counter Intuitive Cholesterol Results
In March last year (2021) I started taking statins in consultation with Dr after risk assessment. I am 62 and have mild narrowing of heart arteries along with mild leak in BAV and I have a 4.9 TAA. In June my non fasting cholesterol levels were: Total 3,0 HDL 1.8 LDL 1.5 tricylcldes 0.7 So after a full
In March last year (2021) I started taking statins in consultation with Dr after risk assessment. I am 62 and have mild narrowing of heart arteries along with mild leak in BAV and I have a 4.9 TAA. In June my non fasting cholesterol levels were: Total 3,0 HDL 1.8 LDL 1.5 tricylcldes 0.7 So after a full
Robfromwales
in
British Heart Foundation
2 years ago
Interesting comparison of different amino acids in different meats
I saw something recently that said beef is better than lamb for PD. Why is that? There is a difference in the amino acids. Could one of them be the cause either because it is higher or lower in beef? Pork was also worse. Chicken good I think? But they do look quite similar. What else would cause one
I saw something recently that said beef is better than lamb for PD. Why is that? There is a difference in the amino acids. Could one of them be the cause either because it is higher or lower in beef? Pork was also worse. Chicken good I think? But they do look quite similar. What else would cause one
LAJ12345
in
Cure Parkinson's
2 years ago
Salmon Protein Hydrolysate
New study below [1]. Anyone here using
Salmon Protein Hydrolysate
? FWIW: "A growing body of evidence implicates iron dysmetabolism in prostate cancer progression. A bioactive peptide-rich salmon protein hydrolysate (SPH) has previously been demonstrated to modulate iron homeostatic mechanisms.
New study below [1]. Anyone here using
Salmon Protein Hydrolysate
? FWIW: "A growing body of evidence implicates iron dysmetabolism in prostate cancer progression. A bioactive peptide-rich salmon protein hydrolysate (SPH) has previously been demonstrated to modulate iron homeostatic mechanisms.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
The end of Parkinson's as we know it today. From the Levodopa era to the "transformative" information era.
1. History and Time. As a vocational and professional historian, I have contemplated the world of Parkinson's for many years. The changes over time in the way the disease is viewed, the possible treatments and everything that makes up the world of Parkinson's (multinationals, neurologists, associations
1. History and Time. As a vocational and professional historian, I have contemplated the world of Parkinson's for many years. The changes over time in the way the disease is viewed, the possible treatments and everything that makes up the world of Parkinson's (multinationals, neurologists, associations
parkinsonshereandnow
in
Cure Parkinson's
2 years ago
Really bad DEXA scan result
Hi folks, I've not posted in a while but have used the time wisely - more about that later. You may remember I was being railroaded into a Zoledronic acid infusion without having a DEXA scan first-the GP insisted I'd need the infusion anyway after being on high dose Prednisolone for more than a year
Hi folks, I've not posted in a while but have used the time wisely - more about that later. You may remember I was being railroaded into a Zoledronic acid infusion without having a DEXA scan first-the GP insisted I'd need the infusion anyway after being on high dose Prednisolone for more than a year
strawclutching
in
PMRGCAuk
2 years ago
Is anyone using/trying this program: Ingredients to prevent or slow progression of PD
Is anyone using/trying this program: any results to report? Ingredients to prevent or slow progression of PD - Knox Van Dyke - Dept of Biochemistry and Molecular Pharmacology, West Virginia University asclepiusopen.com/clinical-... Ingredients to prevent or slow progression of PD (2018): - Inosine
Is anyone using/trying this program: any results to report? Ingredients to prevent or slow progression of PD - Knox Van Dyke - Dept of Biochemistry and Molecular Pharmacology, West Virginia University asclepiusopen.com/clinical-... Ingredients to prevent or slow progression of PD (2018): - Inosine
kstavert
in
Cure Parkinson's
2 years ago
apixiban and vitamin supplements
I have recently been prescribed apixiban for atrial fib. I had been taking a regular series of vitamin supplements including magnesium taurate, zinc, and vit d 3 with k2 and recently added extra k2. at present i take omega 3 supplement and red krill oil. doctor says they are ok. I have picked up the
I have recently been prescribed apixiban for atrial fib. I had been taking a regular series of vitamin supplements including magnesium taurate, zinc, and vit d 3 with k2 and recently added extra k2. at present i take omega 3 supplement and red krill oil. doctor says they are ok. I have picked up the
davcol24
in
Anticoagulation Support
2 years ago
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