Glycyrrhizin in licorice root is a novel pharmacological inhibition of HMGB1 that repress prostate cancer metastasis

High mobility group box 1 (HMGB1) is upregulated in nearly every tumor type. Importantly, clinical evidence also proposed that HMGB1 is particularly increased in metastatic prostate cancer patients. Besides, a growing number of studies highlighted that HMGB1 could be a successful therapeutic target for prostate cancer patients. Glycyrrhizin is a novel pharmacological inhibitor of HMGB1 that may repress prostate cancer metastasis. This research was aimed to investigate the effect of glycyrrhizin on inhibition of HMGB1-induced epithelial-to-mesenchymal transition (EMT), a key step of tumor metastasis, in prostate cancer cells. In this study, HMGB1 knock-downed DU145 prostate cancer cells were used. Silencing the HMGB1 gene expression triggered a change of cell morphology to a more epithelial-like shape, which was accompanied by a reduction of Cdc42/GSK-3β/Snail and induction of E-cadherin levels estimated by immunoblotting. Furthermore, HMGB1 facilitated cell migration and invasion via downstream signaling, whereas HMGB1 targeting by 10 mM ethyl pyruvate effectively inhibited EMT characteristics. Interestingly, cell migration capacity induced by HMGB1 in DU145 cells was abolished in a dose-dependent effect of 25-200 μM glycyrrhizin treatment. In conclusion, glycyrrhizin successfully inhibited HMGB1-induced EMT phenomenon, which suggested that glycyrrhizin may serves as a therapeutic agent for metastatic prostate cancer.

pubmed.ncbi.nlm.nih.gov/308...

HMGB1: A Promising Therapeutic Target for Prostate Cancer

pubmed.ncbi.nlm.nih.gov/237...

Noteworthy, salicylic acid, a metabolite of aspirin, has been recently found to inhibit HMGB1.

pubmed.ncbi.nlm.nih.gov/273...

As an inhibitor of autophagy, chloroquine and hydroxychloroquine specifically inhibit HMGB1 activation

pubmed.ncbi.nlm.nih.gov/237...

[pjoshea13]

Not for me, alas. I'm still trying to figure out why my blood pressure is misbehaving. Never occurred when I had testosterone. LOL

Licorice "stimulates protective factors in the digestive tract, which soothes and supports the lining of the stomach and intestines." However, glycyrrhizin raises blood pressure.

Deglycyrrhizinated Licorice Extract [DGL] has a minimal amount of glycyrrhizin - good for the gut but not much use against PCa.

Monitor blood pressure if using licorice.

I knew many, growing up in England, who were licorice addicts. My local 'sweet shop' sold the root - 2 sticks for a peny in the late 1950s. You could chew on one all day & there would still be flavor left.

Common side effects of licorice include:

Absence of a menstrual period

Congestive heart failure

Decreased sexual interest (libido)

Erectile dysfunction

Excess fluid in the lungs (pulmonary edema)

Fluid and sodium retention

Headache

High blood pressure (hypertension)

Hypertensive encephalopathy

Hypokalemic myopathy

Lethargy

Low potassium levels (hypokalemia)

Mineralocorticoid effects

Muscle wasting

Myoglobinuria

Occasionally brain damage in otherwise healthy people

Paralysis (quadriplegia)

Swelling (edema)

Tiredness

Weakness

rxlist.com/consumer_licoric...

-Patrick

[dhccpa in reply to pjoshea13]

Side effects sounds like Lupron! Should I ask for licorice flavor next time?

[pjoshea13 in reply to dhccpa]

lol

[CAMPSOUPS]

Do you have advanced prostate cancer?

[j-o-h-n]

Please share don't self.........

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 04/17/2022 7:23 PM DST - Holy Easter