Hello!!!

[TazBob]

Hello All!!! I am not sure exactly how this works, so I am just sharing the story I posted as part of my Profile. Thanks for "listening."

I have HER2+ MBC. I originally was diagosed with BC in 2000 (not HER2+), had a mastectomy, and underwent standard chemo. I was on Tamoxifen for 5 years. In 2014, I was shocked when the cancer reoccurred. I was diagnosed with same BC as before, but it was now HER2+. I participated in a clincial trial which I later found out was for Kadcyla. I then started infusions of Herceptin, which I have been doing every 3 weeks. Several months ago I started to have heart issues so the Herceptin was discontinued. In the interim, I developed a small brain lesion and had surgical radiation for it - I don't yet know the results. I am now on heart medication and have just started on a new treatment regime - a Herceptin infusion every 3 weeks plus daily doses of oral chemotherapy - Tucatinib and Xeloda. I am interested in others' experiences with this paricular treatment, as well as others' general experiences in dealing with MBC in the long-term. Thanks very much.

[HelenWi]

hi TazBob,

I’m excited to hear that you’re getting similar therapy to mine. Im taking Xeloda and Tucatinib. I’m HR+ but I have a mutation in my her2 gene so oncologist thought Tucatinib can target my cancer cells. But I don’t need herceptin.

Background: I was on Piqray for 18 months, stable lesions on Petscan but tumor markers kept going up. Brain MRI showed 12 small lesions. They were radiated and we switched to this new protocol. After two months, brain mri showed significant shrinkage of Mets, Petscan report said lesions reso lved and my markers went from 1389 to 79. Needless to say, I’m thrilled. I’m getting another brain mri soon. Of course I’m wondering whether Tucatinib or radiation did the heavy lifting.

Even though I’m using voltaren cream on hands and feet to prevent HFS, commonly caused by Xeloda, I still have very dry fingertips.

I hope it works well for you. As well.

Best

Helen