Kisqali and skin rash

[susiemarmite]

Anyone get hot itchy skin and rash from Kisqali? I’m on cycle 3. 400mg. Been itchy for a few days. Now quite a lot of rash. Does it calm down as the body adjusts?

[Mumberly]

I had that when I first started kisqali. Mine was on my hands mostly, and more like hives under the skin. And it was itchy, like after getting a bee sting. That itch that’s below the surface. And it almost seemed to mirror itself on both hands, inner arms.

I took Benadryl and it cleared in a few days. It came back twice more but only a few spots.

It also made a fairly new scar on my hand flare up. It was so weird. Then, the scar completely disappeared a few weeks later. And the spots haven’t come back.

I hope you find relief for yours

Kim

[DDIL1]

I had a similar rash from Ibrance - Itched like hell. I was told from my Onc to try Pepcid and Benadryl together. Who knew Pepcid was also a histamine blocker. Then I used topical anti itch ointment or cortisone ointment. Helped but eventually I needed a steroid.

Ibrance rash I had

[susiemarmite in reply to DDIL1]

Did it just go ultimately. We’re you able to stay on ibrance without a rash

[DDIL1 in reply to susiemarmite]

After receiving the steroid to get the rash to go away, my body must have adjusted to the meds as I have not gotten a rash since.

[Discocat]

Hello,I’ve mentioned this to you already I think, but this is exactly what happened to me. All over lower arms and legs…I might have a picture as I sent some to my onc at the time….if I do I’ll attach it here.

Initially she told me not to worry…but I came off Kisqali quite soon around that time as my liver enzymes kept rising. That rash came down a bit but didn’t go away until I was off all meds. I was told at this time to NOT take any extra over the counter meds…as they might put extra strain on the liver….so please check with your doctor before taking anything that might effect your liver enzymes.

Take care xx

Arm rash

[susiemarmite in reply to Discocat]

My struggle is that my onc is only in on Mondays and full for another month so I have to manage this myself. How high is high for liver? I’m only 3x over normal range so maybe I can pop some piriton …

[Discocat in reply to susiemarmite]

I went up to 10x above normal range around the time of the rash. I also only had a monthly appointment with the onc at this time but was always instructed to text any queries to her….there’s also a nurse at the centre that I have contact with via email or text who passes info onto the doctor when ever necessary….is there anyone you can contact at your clinic?If possible I’d mention it to someone there to see if you can forward a photo to the oncologist before taking extra meds.

Mine was very strict to not even pop a Panadol at this time….and I think it helped to get the enzymes in check fairly quickly, following her instructions…for me.

xxx Zoe

Also…if they’re not very helpful….play it in your favour and maybe say something like your “worrying that your having a reaction to the medication and your liver enzymes are above normal and you don’t want to cause any further damage”…. Not trying to worry you, it’s just to jolt them into taking some action and passing info onto doctor for you.

[Hazelgreen]

I've been on Kisqali now for six months. My experience over time is that the leg rash lessened, and the itching ceased, but the skin on my legs remains very dry and scaly. The skin on my chest returned to its pre- medication state. However, I'm much older than you, and old skin, once dry, may remain dry....

I hope your skin will return to normal soon.

Warm wishes,

Cindy

[susiemarmite in reply to Hazelgreen]

Good to know it can settle down. I’m 3 months in.

[TammyCross]

I have not been on kisqali, but have gotten a rash from every other medication for mbc. My oncologist says she took me off Ibrance because of a rash. That is weird. because I have had much worse skin reactions to other meds, and I was on it for two years before the rash developed. She did not take me off the oral SERD because it caused a rash even though I have had bumps all over my torso for a year. The worst was Xgeva, which gave me severe eczema.

The relevant part of this is that I saw a dermatologist yesterday. She said estrogen deprives the skin of moisture, so these estrogen blockers are going to cause a level of dryness that can lead to eczema or resemble it, and combined with being old...She said to moisturize like crazy. She also prescribed a topical ointment and told me to use it (I usually don't). She said the over-the-counter low dose cortisone is also safe.