Good news

[mjmom]

biospace.com/article/combin...

[nstonerocks]

Thanks for this. It looks very promising.

[MyMiracle13]

Thank you for this article. More hope for us!

[Barbteeth]

Interesting to read but how many years till it’s approved ☹️

Barb xx

[LouisaMay]

Thanks for the article MJmom. It has made my day. I have lobular MBC and have read that my cancer cells lack the protein E-cadherin. Crizotinib takes out the protein ROS1 which would therefore cause cancer cells to die (cells apparently need one or the other to survive and normal cells have E-cadherin so are fine).

I have also read that traditional chemo is relatively ineffective for lobular cancer. So I was actually planning to ask my onc if I could have a micro-dose of Crizotinib for a long time to see if it helped.

Of course I am pretty sure he will say no, but I fully intend being 'that' feisty patient that they get fed up with. I fear that the required clinical trials may mean that this becomes standard after Ibrance has run its course for me...but I will do what I can to persuade him otherwise.

[worldtravel75 in reply to LouisaMay]

thanks so much for your info on lobular breast cancer - I am researching the hell out of this but did not see your info when doing so - I am going to dana farber in Boston next month for a second opinion - I am pretty sure my Ibrance is starting to fail me after 7 months so need a back up plan

[LouisaMay in reply to worldtravel75]

Good luck, please let us know how it goes xxx Have you thought of taking a look at the Care Oncology Clinic protocol? x I intend signing up to that in the next couple of months or so.

[LouisaMay in reply to LouisaMay]

Hi again, here is a link to the original article I found:

breastcancernow.org/news-an...

[mariootsi]

Wow sounds good. Thank you for sharing. Gives us hope as we all know there will come a day unfortunately when we will have to change meds!

[LouisaMay]

Here is an article that suggests that some women with HER2 negative metastasised lobular breast cancer may respond very well indeed to treatment for HER2 positive patients. They don't seem to know why yet but who cares about that? x Something else to suggest to the oncologist if he doesn't suggest it himself.

ascopubs.org/doi/full/10.12...