Liver mets not responding to taxol

[Abdallahfarag]

What is treatment for liver mets after taxol and Xeloda failure

[Ibelong]

In my case, Her2-, PR - and ER +, Gemzar and Navelbin infusion chemo for liver mets and bone progression after bad Taxol/Doxil allergy, then Xeloda, then Ibrance and Letrozole. I just posted my experience. 8 months and at least stable. Ask your provider if that is what might be next for you. I can give you more insight on my experience if I haven’t scared you with my post.

[Clair19 in reply to Ibelong]

May I ask how large your lesions are on your liver? The reason I ask is mine was 4 mm and my oncologist doesn’t seem worried? I think he’s more focused on my lung because that is where my nodules and plural effusion is. I was hoping that the fluid would go away as my nodules shrunk, but it’s always a small amount. Thanks so much. And continued good scans!

[Ibelong in reply to Clair19]

I had the nodules to with effusion. My nodules did turn out to be mets and my mass in the nodes in the chest that were swollen were as well. My effusion was large. They took 2 liters fluid out. No malignancies found in the fluid. This was successfully treated before the liver mets showed up. Lung mets can cause many issues while the live has a special way of healing. He may be targeting the lung and possibly what ever treatment he uses will help both the lung and liver.

To answer your question about my current liver mets. As of my last scan in June, I have multiple liver mets. The smallest is 1.8 by 1.4 cm, the largest being 5.0 by 4.6 cm. There were a total of four measured. The report indicates a total of 10 lesions all together.

I hope this helps you. At least form questions for your oncologist. The reason I asked what doc was worried about the lung mets is because I saw a pulmonary doc when I began having breathing trouble. I wished I would have only seen my oncologist. The pulmonologist never spoke to my oncologist until the lymph node mass was 4cm. I was real upset. It grew and he never told me. Even when the pulmonologist knew of my cancer history.

[Clair19 in reply to Ibelong]

I’m sorry to hear that about the pulmonologist! I just see one Dr. my oncologist, except my GP who I worked with and enjoy talking with him as he was the one who suspected cancer. Yes the liver will heal once you get things under control. I’m not going to complain about my one 2-4 mm liver lesion, you have a lot going on. I’m like you with lung Mets, all through rt but left still clear. I do get winded if I over due it. I’m scared to let them drain because I’m old school believe any air or possible injections would fuel my lung Mets. So I left it alone and it went from massive amount to small. When where you originally diagnosed? I got 17 years before mine came back last summer. I went 7 months before treatment but everything stayed stable, then Red Devil for 6 months and I have a hard time with targeted therapy due to Neutrophils. I’m just taking Faslodex right now. Please keep me posted as I would like to see how your doing! I will say a prayer for you!

[Ibelong in reply to Clair19]

Hi Clair19. I do have a lot going on in my liver and bones right now. It’s crazzzzy. It’s been a long haul. I was 36 in 2007 when I was finally diagnosed. I kept bringing my breast issues up on closed ears. My general practice doc told me for four years that I was to young with no family history to have breast cancer. They were fools. I too for feeling comfort in that. When I got my diagnosis it was metastatic. It had already migrated to the bones. I was without disease after my chemo therapy and hormone therapy treatments for 7 years.

Honestly the scariest was my lungs. I knew that the cancer could come back. But in my lungs it felt like it was squeezing my life away. I had so many issues. They kept testing and telling me about nodules and left the mass for a surprise.

Any way the draining was easy after all was said and done. The team of nurses techs and new doc were wonderful. What I hated were the bronchoscope and the biopsy of the mass in my chest lymph nodes. It was scarier to me than my initial diagnosis I guess because I had so many symptoms. And hardly any for the breast also in the breast the original cancer could be surgically removed. Half the battle then the hope was on chemo. Then when I was told my lung was inoperable. I thought like you to I didn’t want surgery any way. I wanted the choice. I thought it better to get it all out but, like you I was apprehensive about doing so incase it just made it spread more. With symptoms worsening it took a year before all the testing from asthma, sleep Apnea to GERD and everything in between was done before my diagnosis that came by way of 4 cm mass. I think I had good insurance and doctor was playing games and used it as bank. I sound skeptical but that is how I feel about him. The patient was not his best interest. It was what was in his bank. I was frustrated because I felt i wasn’t being heard again.

The thing with small effusions they can go way. I had a few show up on scans and gone on the next. Hopefully you will not need to be drained. If you do it’s really self contained. As well as an easy procedure. I hope you will not have to because the nodules will go away.

I have monthly appointments and scan every 3 months. I will be happy to keep you updated. Please tell me how you don’t progress and get to no evidence of disease. I hope it goes that direction. You to will be in my prayers. My Las scan was June so I am due in about a months time.

Have a beautiful day.

[Abdallahfarag in reply to Ibelong]

Thanks for your sympathy and may Allah be with us..

My mother was the patient and she had bone mets, eye, lung and brain she was treated by Xeloda, for 1.5 year or more then brain radiotherapy then continue on Xeloda till she have hand foot syndrome and resistance to it so her doc shifted her to taxol since 4months and it doesn't work in addition she developed liver mets in recent scan with normal liver function so I don't know if he will shift her to any drug and it will be single or combination

[Abdallahfarag in reply to Abdallahfarag]

Good evening all. We went yesterday to oncology doc and prescribe my mother new regimen gemzar plus carboplatin and we hope that it work for her isA