PBC and Hepatitis

Hi Everyone,

Festive greeting for all on the first day of December.

I was confirmed PBC 2 1/2 years ago with blood tests and liver biopsy.

A week ago I saw my specialist after my GP had phoned him with some concerns. The consultant told me from original blood works done on me he thought I had both PBC and Autoimmune Hepatitis, however the biopsy at time did not show enough to confirm the hepatitis. My liver function tests have always been high even on Urso although they had settled. the consultant said that previous two blood tests shown a dramatic increase that suggests now I also have hepatitis, he took more blood and said if still so high then I will be put on steroids for a bit..

Has anyone had a similar experience?

right now I am unsure if he is saying I have it or not/

Kind regards and warm wishes for all



4 Replies

  • Hi, Angela.

    Short of another biopsy, there isn't really another way to diagnose AIH. In lieu of that, often a biochemical response to steroids will inform.

    Remember, a biopsy needs sufficient cell change to register a result (be that PBC, PSC or AIH) and it can be possible to have one of those conditions (or two) and still have no liver damage.

    If we can help further, do get in touch directly.


  • Thanks Robert,

    I couldn't go through another biopsy, had rough time with last one..

    Thanks Again


  • Hi Angel, do you know any details from your blood work? I think Autoimmune Hepatitis is suspected when you test positive for ANA and/or SMA antibodies. If the biopsy did not confirm AIH, they may have delayed making a diagnosis. But, that doesn't necessarily mean that you don't have AIH.

    I think steroids are usually prescribed for AIH to suppress the immune system and decrease inflammation. It should help to bring your LFTs down.

    That's about the extent of my knowledge on AIH. Perhaps others can help with more info?

  • Hi Chynablue,

    My biopsy was done 2 1/2 years ago and that is when pbc was confirmed , I always have raised lft's, however past couple of blood results are showing a large rise in the ones associated with autoimmune hepatitis. Waiting now for the bloods to be tested again before being out on steroids.


    Angela xx

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