I have two SNOS on two parts of the MTHFR gene. I alway have ordered methyl B12 injections knowing I had this methylation issue. What I couldn’t understand is why I needed three injections a week of methyl B12 to have enough energy to get through the day. Recently, I came across an article on TMG , also known as Betaine Anhydrous. Body builders and athletes seem to use it for faster recovery from workouts. In that article, they talked about it being a great methyl donor. I decided to try it because MYHFR is a methylation issue. Oh my goodness! I started forgetting to take my Methyl B12 injection. I’m down to once every two weeks and expect I will be able to continue to reduce the frequency. ( For reference, I’ve been taking injections 3X a week for approximately four years! I could not reduce it until I started the TMG supplementation.
It’s inexpensive and I’ve bought it on Amazon, Bulk Supplements powder. Here is how I’ve taken it:
Start with 3,000 mg= 1 teaspoon first week
Then: 3/4 tsp. For 2 weeks
Then 1/2 tsp. + 1/8 tsp.
( my notes say you may be able to maintain as low as 1/4 tsp per day.
I am taking 1/2 tsp. Per day currently and have not attempted to reduce.
I hope this helps someone else.
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oh my goodness thats great I'll have to look into this, I have the mthfr for folate methylation gene, I'll have to read up on this product. I wonder what it does.
It’s a methyl donor, as I understand it. I think I needed the B12 injections as frequently as I did, because my body was using it partly as a methyl donor. I was scrolling one day and saw something about it being a methyl donor and a light went on. Maybe that’s why i need Ed such a high frequency for so many years. Someone here mentioned Nicotinamide and NAD. Neither made a difference for me. This is an inexpensive supplement to try. I would buy a small bag of the powder from Bulk Supplements and proceed with the sequence I described in my original post.
well I may try this then, yes I had an answer to my prayers with a methyl folate that agrees with my stomach , I have PA and 8 months into injections everyday, is this a safe suppliment for long term I wonder, I hope so as it will be great to have.
Very interesting! I took TMG for a couple of years in effort to bring my homocysteine down, to no avail. I will start taking it again to see if it can help me utilize my B12 better. Thank you for sharing!
I took Betaine HCL TMG and then discovered that for me NAD was more effective and then that B3 in the form of Niacinamide was even more effective.
From memory I took 1.5 g of Betaine 5 to 6 times a day as I had found less to make no difference.
I tested negative for the MFTR but the test was developed by the local hospital and may not be as dependable as the established genetic testing companies.
I have found Methyl to be much more effective although for me it does not cause 'anxiety' rather it heals my neurological system and I can now process trauma in a way that was not possible before. Hard work that!
I had done 23andMe dna testing some years ago. One of my doctors said I should download/upload? the raw date to geneticgenie.org and ask for a methylation profile, I also did a detox profile. At the time there was no charge. Then I studied up on the results. There is a lot of youtube. I started on TMG with great results. But I should experiment with increasing my dose, which I call tri methyl glycine. Can anyone answer this: I'm finding I need to take betaine Hcl in the middle of the night. Is this related to the betaine anhydrous?
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Self injecting Hydroxocobalamin subcutaneously
Folate
changing hydroxo and methyl dosage. 
