my wife is poorly having all symptoms of B12 deficiency. Unfortunately GP is not helpful, she seems oblivious to this problem, that's very worrying. I provided GP with many papers including stuff produced by pernicious anaemia society, haematology committee, Sally Pachaloc etc also the video by Sally Pacholoc regarding B12 David Carr etc. All this includes many references that blood tests are not reliable and that symptoms are the best guide. Disappointingly GP done a blood test, results were in reference range, GP said there's nothing wrong with her B12, despite confirming he watched the video. So my wife is supplementing with methyicobalamin SI every other day. My wife has serious peripheral neuropathy, no balance, unable to walk, extremely exhausted, energy completely gone, I still have hope even though she has suffered with serious neurological problems for some time.
She has MTHFR mutation C677T plus 4 homozygous and 9 heterozygous mutations. these methylation profile results appear to me she has an inborn with B12 she has difficulties taking B12 up, she looses it to quick, and also can be depleted by ACAT1-02 (this is as I understand)
She is not improving by SI B12 does the above indicate because of the length of time with neuropathy etc, she would need her doses of B12 or is she in need of other vitamins to help absorb B12, any thoughts would be appreciated as my love is so poorly, thankyou.