Could somebody please help me get to the bottom of what is wrong with me? I have had raised MCV on my FBC for several years now (5-6+), my MCH has been in range for the last couple of years, but had also been raised for a couple of years previously. Last January I was told by my GP I had folate deficiency my result was 4.4 I supplemented with folic acid for a month and when retested a couple of months later it was at 26.0, problem solved, however my MCV is still continually raised. I have neuropathy of my hands feet and tongue, burning sensations/pins and needles, I have had problems swallowing bulky foods on and off for the past 18 months, fingernails are falling to bits and have faint white lines near the top, mild hair loss. I have had IBS since my 20,s I am now 47, however I have had chronic diarrhoea for the past 2 years. I am now suffering from fecal urgency, no warning and urinary stress incontinence/urgency. I was diagnosed with psoriatic arthritis 7 years ago, auto immune in nature. I have had my thyroid tested several times, also for diabetes and tested for coeliac disease, all negative. My B12 was at 284 at the same time as my folate deficiency, this further dropped to 247 a few months later. I take omeprazole as I am on celecoxib anti inflammatory for the PSA along with steroids, sulfasalazine, leflunomide etc I have been on most of these medications for 7 years bar the leflunomide which I restarted last summer after a 10 month break. My GP put me on some B12 tablets in November for a month then retested, my level had gone up to 295, I requested some more as I thought my level was still quite low and he obliged. I have just been retested and my B12 level is now 411, folate 13 with no supplements since the beginning of last year, but my symptoms are not improving and my MCV is on the rise again. I have been to see the dental team at Guys regarding the burning tongue and she is in agreement that it is a neuropathy, she has advised for neurological testing (nerve conduction test) she also did an iron panel test as my ferritin has been low for quite a while (In the 30’s) but has dropped in the last 9 months to 16, however my iron level results came back within range???? She also tested zinc and this was borderline low. Any ideas? Anyone?? Can I just add that all my liver results have been fine and urea and electrolyte all come back normal, although my potassium does keep dropping, but still within range.
B12 deficiency - can I still be defic... - Pernicious Anaemi...
B12 deficiency - can I still be deficient with a normal blood level?
A high result for MCB can indicate macrocytosis, a symptom of PA . To me ,your other symptoms point to PA . You can have a high level of B12 and still have PA , if it isn’t getting through to your cells ( it happened to me ) Having PA also leads to low or no stomach acid , ( gastroenterologist told me ) which upsets the stomach flora. leading to IBS . I cured my IBS with a fantastic but expensive probiotic called Symprove . Home made raw organic sauerkraut is just as good and very cheap. It sounds as though you need injections of B12 ( Hydroxocobalamin ) You need a test for the Intrinsic Factor which is VERY unreliable. If positive it proves you have PA . If negative it does not disprove it ! Yes very difficult . Have a go with your GP . If you have difficulties , come back here for further advice . Best wishes .
Unfortunately my GP thinks my serum levels are fine and just gave me more B12 tablets to get rid of me, he won’t entertain the cell thing and would not do any of the other tests I asked for, also refused injections, he hasn’t followed the NICE guidelines and not sure he appreciated all the test suggestions and said they don’t deal with that! I know the tests are not always accurate but I though they may give an indication of what the problem was eg HoloTC, IF, Parietal cell antibodies Homocysteine. I’m now at a bit of a loss as what to do, I am not going to take the B12 as they will just make the level even higher 😳
Omeprazole will totally negate any stomach acid which you desperately need for processing all vitamins and minerals . Deadly stuff .
Yes but unfortunately I need to take them for my anti inflams 😟
It can take several months for macrocytosis to clear your blood - so if you are talking about the difference between results in January and those in February seeing an improvement is what you would be expecting - not seeing the MCV being back to normal.
Folate is very responsive to in take so sounds as if your deficiency has resolved but you may still have absorption problems.
A drop from 284 to 247 isn't significant - it is roughly what you might get from running tests twice on the same sample. The rise is significant but how significant depends on the strength of the tablets you were being given. What was the strength of the B12 tablets you were given?
The symptoms of folate deficiency are very simiilar to the symptoms of B12 deficiency
With normal levels of b12 can you still be deficient 
B12 level in normal range but still exhausted
On a standard b12 blood test my levels are normal can I still be b12 deficient?
B12 deficiency, injections and blood test results
