Tiredness is horrid: Over the last 6mth... - Pernicious Anaemi...

Pernicious Anaemia Society

32,513 members23,811 posts

Tiredness is horrid

dee2382 profile image
6 Replies

Over the last 6mth iv had several bloods done and the following are results. Some antibodies measure a value and only 1 says not detected.

GAD- POSITIVE

INSULIN AB- *<0.4 (NORMAL HI <0.4)

Thyroglobulin Ab- <21 IU/ml (high norm <40)

Thyr Microsomal Ab - 11 IU/ml (high notm <35)

TSH Receptor Ab- *<1.0 U/L

Intrinsic factor Ab- 2U/mL

Gastric Parietal Cell Ab- not detected

TSH - 0.59 (down feom 1.30)

ACTH- 9.8pmol/L (high norm <10)

Cortisol- 115nmol/L (down from 178)

Vit D 30- deficent

B12- deficient and f olate part was 1800 so had B12 injections need new bloods.

About to have a stim test for cortisol stuff

I have LADA (adult onset type 1) as of June this year.

Now- is INTRINSIC FACTOR positive (other gastric par cell says not detected). I assume all positive with only GPC not detected.

Am i looking at Pernitious anemia? Have a lowish HBa1C of 5.3% and if PA then its false low. I had some steroids earlier in june - felt amazing. But now back to being tired. Tempted to get MTHFR gene tested. Not sure wjll help but....

thanks for any advice you can offer.

Dee x

Written by
dee2382 profile image
dee2382
To view profiles and participate in discussions please or .
Read more about...
6 Replies
Galixie profile image
Galixie

Does your lab test paperwork list the reference ranges? Every lab is different and you need those values to be able to interpret your results. If the copies you have don't include the reference ranges, it would be best to ask for them. You're kind of in the dark without them.

dee2382 profile image
dee2382 in reply to Galixie

Cortisol 115 (82-960)

(A retest when emerg hospital admit was 199 4wk ago)

B12 mine was 115 - (135-650)

Folate 1800nmol/L - (776-1784)

Vit d 30 (51-84)

AB ref ranges are inc above or arent avail.

dee2382 profile image
dee2382 in reply to dee2382

TSH 0.59 (0.5- 3.50)

Galixie profile image
Galixie in reply to dee2382

Usually there is a range for antibodies where they can be present in the body but not be considered high enough to be a positive result. Without knowing what the lab's range is for that test, it is difficult to say whether that intrinsic factor antibody test was a positive result or not.

You definitely have a too low B12 level and it looks like your vitamin D level is also low. I know nothing about thyroid but I suspect that your result might be verging on too low there also.

Were you supplementing folate at the time of the test? Was a complete blood count also done?

Both the B12 and D levels should be treated. They are clearly low.

Hopefully someone more knowledgeable about thyroid can advise on that one.

I might be mistaken but I think it's fairly uncommon for people without pernicious anemia to produce any intrinsic factor antibodies, so it may very well be a positive result. Unfortunately, you'd really need to check with the doctor or lab for confirmation.

Gambit62 profile image
Gambit62Administrator

Your B12 definitely low.

the IFA result does indicate that you are producing antibodies which would mean PA as I understand it - an autoimmune response that destroys the mechanism by which your body absorbs B12 - though there are are some medical definitions that only describe it as PA when the mechanism is actually starting to cause damage but I'm not clear on what they are.

In any case you have an absorption problem so need to be treated.

The folate is abnormal and could imply that you have a methylation problem (MTHFR). If you decide to take supplements then approach methylated forms with care - there are different genetic variations involved in MTHFR and although the general assumption is that you need methylated forms of folate and B12 if you have an MTHFR genetic variant things aren't actually that clear cut and some variants actually respond very badly to the methylated forms.

You might also want to look at coeliac's - and consider a gluten free diet - think this might help as well with blood sugar levels from what I have been reading about glycaemic index recently.

Laura5 profile image
Laura5

One reference range for normal values for IF antibodies I've seen is 0 - 5.9 u/ml - which would make your result normal on that range.

Not what you're looking for?

You may also like...

Searching for a diagnosis (DESPERATELY) Please helpppp.... Is B12 deficiency / PA possible with these blood tests??? NEW HERE

Hi All, I’m new on here and can’t believe just how brilliant this forum is so thanks for having...

Assistance required with interpreting B12 and Pernicious Anaemia Blood Tests.....

Hello I was wondering if anyone here could help me in interpreting some Vitamin B12, Intrinsic...

IFAB testing guidelines per Mayo clinic laboratory website

I found this IFAB test guideline. I found a few things pretty interesting. This particular lab...

Post-treatment lab results -- interpretation help appreciated!

Hi, everyone! I'm hoping those of you who have more experience appraising lab results can help me...

More Test Results ...any advice very warmly welcomed..

Hello lovely PA Folks - Well, after some hectic Facebook marketplace efforts, and delay for...