Took my 2nd 50mg injection of Enbrel 2 nights ago. Spent most of yesterday in bed, completely wiped out. Also had terrific bilateral knee and ankle pain through the day and night even with maloxicam and tylenol. Feeling a little better today but still fatigued. I'm wondering if this is Enbrel doing this? I've also reduced my methotrexate from 20mgs to 10mgs. Any feedback is greatly appreciated.