Benepali versus enbrel - worried?

Hi there, I have been injecting Enbrel for two years and it has made a difference (I have psoriatic arthritis and ankylosing spondylitis), I also inject methotrexate. I have now received a letter from my hospital informing me they are withdrawing Enbrel and replacing it with a"biosimilar" benepali to save money. Is there anyone out these who has experienced similar oe. changing from Enbrel to Benepali, and did they experience any side effects, I am quite concerned because this is new and they do not know what the long-term side effects are.

12 Replies

  • I had to change from enbrel to benepali about four months ago and like you I was concerned because it's new and I didn't like the idea of being one of the first to use it. However, the changeover was problem free, I have had no side effects so far and it seems to be as effective as the enbrel. I find the pen easier to use than the enbrel pen and it is almost pain free! Good luck with it, I hope it works well for you.

  • Thanks Astral, I hope it works well too.

  • Hi I'm on Benepali and it's been working great up until this weekend when the fatique kicked in, but I think because I've been pain free I've been over douning it at the gym and it's caught up with me so I'm relaxing in bed today

  • Hi I've switched from enbrel to benapali too and have found after a few weeks on it my fatigue has gotten worse. I am worried that it is not working well. Did your fatigue improve?

  • Hi pm52

    You could be me posting, I too am about to be switched onto Benepali so totally understand your concerns.

    I've got 5 weeks of Enbrel left and the Benepali is being delivered next week.

    I've heard the injection us even easier than Enbrel.

    My Rheumy nurse said to think about it like Nurofen ( brand name) and Ibruprofen (generic)

    So the active ingredient in both Enbrel and Benepali is Etanercept.

    Good luck and we can compare notes in a few weeks time.


  • Hi Mandalou. thanks for your message, I have 4 weeks Enbrel left and have no idea when the Benepali is being delivered, just received a letter from the hospital saying they would be in touch again, so now worrying that there may be a gap. Will let you know how I get on and we can compare notes. x

  • Dear pm52,

    Hopefully the posts above have reassured you somewhat regards the Biosimilar you have been switched to but please do contact the NRAS Helpline or contact your rheumatology team if you have any other concerns or questions.

    NRAS has been involved in previous NHS England workshops on Biosimilars and we have lots of information about them on our website here:

    We are also keen to hear your experiences (both positive and negative) about switching to Biosimilars so please do get in touch with us using the email address on our website.

    Kind regards


  • Hi I have just joined here after discovering these posts. Like the others I have switched from enbrel to benepali and after a few weeks I have found that my fatigue has gotten noticeably worse and I am worried that benepali may not be working quite as well for me. I was wondering if you have been informed of many people experiencing what I've described or if it could just be a flare up for me? Thanks

  • Thanks for your reply Emma, but I have not switched. The pharmacist at my hospital tried to persuade me but both my physiotherapist and even my consultant quietly advised to remain on Enbrel as long as I can. At the moment I can choose, I guess the time will come when I will have no choice and I will be moved over to Benepali, but from what I have heard it is not as good, so I am sticking with Enbrel for as long as possible.

  • Thank you Emma, I will have a look at that link to your website and will let you know how I get on - good or bad.

  • Hi, I switched from enbrel to benepali and three weeks later my fatigue is the same as before starting enbrel. I also notice more pain and stiffness, it is definitely not working for me unfortunately :(

  • Oh dear, that is not good, any chance of going back or is it too late? I am glad I had the choice and stayed with Enbrel.

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