Hello everyone my story has been posted. Years of treatment resistant depression. ECT, 25 different medications, as well as a lot of alternative treatments. Update and maybe some good information and I would like to hear as well from people in the same boat, so to speak. I now take tramadol for pain, which lifted my depression. I am back on track, feeling good most of the time. Tramadol really doesn't do much for the pain I am in, but it brings me up to a normal level. I am losing weight, getting things done, improving my relationships, taking better care of myself. I could go on, but I think you get the gist of what I am saying. It turns out that many people with treatment resistant depression have discovered by accident, as they had to have a surgery and they were prescribed tramadol, that it relieved their depression. Don't want to make this too long, so all is well and please, if anybody else has had the same experience, I would like to hear about it. To all those suffering, I feel for you, and hope that some day the fog lifts and the sun shines bright for you. Take care of yourself, you are worth it.