Does anyone else here have bad side affects and reactions to antidepressants or mood stabilizers? I really wish I could take something to help with my depression and anxiety, but unfortunately... I can't. I have horrible reactions to medications. It leaves me feeling a bit helpless sometimes. I can't seem to overcome this depression. It's a little disappointing not being able to take medications to help. I've tried taking St John's wort, but it doesn't help.