Wellbutrin help

[marley_son]

I was on Zoloft (50 mg) for over 25 years. All of sudden about 7 weeks ago I fell into a deep depression and couldn't get out. My doctor prescribed Wellbutrin for me and I started last Thursday. It did brighten my mood, but it's been up and down. Mostly up, but there have been downs. They raised me to 300 mg along with 25 mg of Zoloft.

I still have a bit of mental fog. Not unbearable like I was 2 weeks ago (or even last weekend), but still here. I'm just not sure this is going to be a long-term solution for me the way sertraline was for so many years. Anyone got any advice?

[Giggler0420]

I’ve been on the same combo as you except maybe a lower dose of Wellbutrin for about 5yrs. This is the first combo that has truly worked for me. It did take 2-3 weeks to fully “kick in” and it did pull me out of a deep low. However it doesn’t seem to be as affective anymore. I will be speaking with my doctor soon about what to do next. Perhaps just increasing the dosage? I’ll post what I find out. For me, it’s been a lifetime of trying new meds because although they work for a little bit I haven’t found one that is a long term solution. It’s frustrating and exhausting.

[marley_son in reply to Giggler0420]

Zoloft worked well for me for over 25 years, so it was baffling and quite scary when it just suddenly stopped working. I'm so sorry you haven't found a more stable solution. Can I ask what symptoms you're having now that it's stopped being as effective?

[designguy]

You might check to make sure you hormones (testosterone), thyroid and adrenals are functioning properly, if not they can can cause or contribute to depression/anxiety. Getting on testosterone replacement therapy helped me.

[SHEPHER]

I have been on 125mg Zoloft for 10years and been great I had a health scare and triggered my anxiety and depression I have tried upping it but no joy Mt Dr wants to wean me off and start me on duloxetine I am so frightened. Hope you get sorted