Am preparing for IV zolendronate treatment to start soon, and at a recent Rheumatology Metabolic Bone Unit appt, the consultant noted my persistently low WBC & IgA + widespread dryness symptoms (my skin + every hole in my bod has a long term NHS clinic-prescribed treatment plan monitored annually in clinics), and said he believes that currently my secondary sjogrens is more active than my primary systemic lupus (infant onset)...and that he thinks my recent phase of persistent UTIS + kidney infections was caused by sjogrens dryness + these low bloods elements (both my lymphocytes & immunoglobulin A are always just below the acceptable normal range.)
I have been prone to infections. Especially of the respiratory tract & also Kidney + UTI infections (which have occurred in persistent phases throughout my adult life, so much so that I'm now resistant to various oral antibiotics). My infant onset lupus went unrecognised when I moved to the UK in the late '70s. 4+ years ago when I was in my late 50s, rheumatology finally recovered the SLE diagnosis & added sjogrens to my diagnosed secondaries. I'm responding well to a treatment plan of daily hydroxychloroquine 400mg + Mycophenolate mofetil 1000mg, with low dose 4 week pred tapers during neuro cerebral flares.
My feeling had been that 2 1/2 months recently on cefalexine 500mg for my first persistent UTI & kidney infection in 2 years wasn't simply down to being on immunosuppressive meds....so I found my consultant's recent comments re active sjogrens + low WBC & IgA intriguing...and I'm posting this question now to see if anyone on forum has had a consultant tell them pervasive sjogrens dryness can predispose us to infection...I'm particularly interested because I've had long term oral antibiotic treatment for osteomyelitis of the upper jawbone/sinus and although I've been considered 'clear' for 2 years, I'm keeping my eyes wide open as I start IV bisphosphonates for osteoporosis!