I have been on Methotrexate since Feb of this year, and gradually came of oral steroids,which I had stopped taking by June-had to have a steroid injection in August, as was still struggling a bit (although much better than I had previously been) I had built up Metho (as advised by Rhuemmy to 17.5mg weekly) but at Oct appt with Rhuemy was told to lower dose to 12.5mg, due to high liver readings, and also started taking Quinoric (400mg daily). Past week or so, I could feel myself flaring a little, and went to see Nurse, who took a blood test and told me to stop taking Metho completely,immediately-she gave me another steroid injection as she predicts that I could go into a major flare, as my inflammotory markers were also high (I can feel it starting already!!) Have to have a repeat blood test in 2 weeks and then we are going to take it from there (am still on the Quinoric 400mg daily)...Any advice or suggestions??? Is there a good alternative to Methotrexate that is not so harsh on the liver??? (I am Tee-Total, by the way...so it is not alcohol that has caused the rise in liver reading) Feeling a bit low, as felt had finally got meds sorted, and was (almost) leading a 'normal' life (still a bit of pain, but bearable with over the counter inflammatories) Feel we are now back to the drawing board, so to speak!!