This was the first EVER, sanctioned by the government, multiple gene editings to the human genome by a company and the results were:
First, we can successfully perform multiple edits with precision during manufacturing, with the resulting cells surviving longer in the human body than any previously published data have shown. Second, thus far, these cells have shown a sustained ability to attack and kill tumors.
One of the editings was the removal of the checkpoint, PD-1...Checkpoints are what cause the slowing down of immune attack because cancers--demons that they are--can disguise themselves like wolves in sheep's clothing--see easy explanation below:
blog.dana-farber.org/insigh...
By doing this, they can infuse T cells that will provide a sustained attack and will not be so easily tricked by cancer cells not to continue the attack...Secondly, there are drugs in development to stimulate macrophage attack against cancer cells which I have posted on--see below:
healthunlocked.com/advanced...
Could a drug like CpG be added to these engineered T cells to further the T cell attack by getting macrophages involved? Absolutely, IMHO--a double attack...
Finally, could an infusion of these engineered T cells be combined with CpG or a CLEVER-1 inhibitor AND...pick one:
1) Checkpoint inhibitor
2) PARP inhibitor
3) Lu-177 or AC-225
4) SM-88, a metabolic drug under development...
5) There are others under development...or here--chemo, etc..
Thus, a 3 pronged attack...or more...
The Science is Coming !!!! and it gives us...HOPE !!!
Don Pescado
